Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Onchocerca volvulus | Peroxidase homolog | 0.0064 | 0.3886 | 0.3163 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1057 | 0.199 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1706 | 0.3274 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1057 | 0.199 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.3886 | 0.3886 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0798 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1057 | 0.1057 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0798 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1706 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0798 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0064 | 0.3886 | 0.3163 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1057 | 0.1057 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0798 | 1 |
Onchocerca volvulus | 0.0064 | 0.3886 | 0.3163 | |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0798 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Onchocerca volvulus | 0.0146 | 1 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1706 | 0.1604 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.008 | 0.5104 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1057 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1706 | 0.1706 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1057 | 0.199 |
Brugia malayi | Blistered cuticle protein 3 | 0.0064 | 0.3886 | 0.3886 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.008 | 0.5104 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.1057 | 0.199 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0798 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0798 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.3886 | 0.3886 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1706 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.3886 | 0.3886 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0798 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0064 | 0.3886 | 0.3886 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0798 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0064 | 0.3886 | 0.7589 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Onchocerca volvulus | 0.0064 | 0.3886 | 0.3163 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5104 | 0.5104 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1057 | 0.1057 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.7715 | 0.7715 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Onchocerca volvulus | 0.008 | 0.5104 | 0.4525 | |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1057 | 0.1057 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1057 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.008 | 0.5104 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0016 | 0.0016 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0798 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1057 | 0.1057 |
Onchocerca volvulus | Peroxidasin homolog | 0.0064 | 0.3886 | 0.3163 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1706 | 0.3274 |
Schistosoma mansoni | peroxidasin | 0.0064 | 0.3886 | 0.699 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0155 | 0.0155 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.008 | 0.5104 | 0.5104 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Schistosoma mansoni | peroxidasin | 0.0064 | 0.3886 | 0.699 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0798 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0064 | 0.3886 | 0.3163 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.7715 | 0.7715 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1021 | 0.1021 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1706 | 0.1604 |
Brugia malayi | Peroxidasin | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0051 | 0.0051 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0064 | 0.3886 | 0.3163 |
Onchocerca volvulus | Dual oxidase homolog | 0.0064 | 0.3886 | 0.3163 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0155 | 0.0155 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1706 | 1 |
Onchocerca volvulus | 0.0064 | 0.3886 | 0.3163 | |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.7715 | 0.7715 |
Echinococcus granulosus | peroxidasin | 0.0064 | 0.3886 | 0.7589 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3886 | 0.3886 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.3886 | 0.3886 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.