Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Schistosoma mansoni | eukaryotic elongation factor 2 kinase (eef-2 kinase) | 0.0111 | 0.5406 | 0.539 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.019 | 0.9513 | 0.9512 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0168 | 0.8343 | 0.8765 |
Echinococcus granulosus | protein kinase c iota type | 0.0014 | 0.0433 | 0.042 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0038 | 0.1686 | 0.1657 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0273 | 0.0239 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0273 | 0.0239 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0024 | 0.0958 | 0.0974 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0014 | 0.0433 | 0.0399 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0029 | 0.1172 | 0.0279 |
Schistosoma mansoni | serine/threonine protein kinase | 0.019 | 0.9513 | 0.9512 |
Entamoeba histolytica | protein kinase 2, putative | 0.0026 | 0.1047 | 0.1886 |
Echinococcus granulosus | defective proboscis extension response | 0.0011 | 0.0273 | 0.0251 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0014 | 0.0433 | 0.042 |
Echinococcus granulosus | nervana 2 | 0.0024 | 0.0958 | 0.0974 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0024 | 0.0958 | 0.0974 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0014 | 0.0433 | 0.0399 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0273 | 0.0239 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0011 | 0.0273 | 0.0239 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0032 | 0.1367 | 0.2463 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0026 | 0.1047 | 0.1068 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0418 | 0.0385 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0026 | 0.1047 | 0.1068 |
Echinococcus multilocularis | protein kinase c iota type | 0.0014 | 0.0433 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Echinococcus granulosus | nervana 2 | 0.0024 | 0.0958 | 0.0974 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.1367 | 0.2463 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0014 | 0.0433 | 0.042 |
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Schistosoma mansoni | kinase | 0.0058 | 0.2711 | 0.2685 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.018 | 0.8952 | 0.8948 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0029 | 0.1172 | 0.1142 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.019 | 0.9513 | 0.9512 |
Leishmania major | myosin heavy chain kinase a-like protein | 0.0111 | 0.5406 | 0.9651 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0029 | 0.1172 | 0.2112 |
Echinococcus multilocularis | nervana 2 | 0.0024 | 0.0958 | 0.0974 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0014 | 0.0433 | 0.042 |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0087 | 0.0052 |
Onchocerca volvulus | 0.0164 | 0.8145 | 0.8557 | |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0011 | 0.0273 | 0.0251 |
Trypanosoma cruzi | Protein kinase B | 0.0029 | 0.1172 | 0.0279 |
Echinococcus granulosus | NDR protein kinase | 0.0014 | 0.0433 | 0.042 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.018 | 0.8952 | 0.8948 |
Trypanosoma cruzi | myosin heavy chain kinase A, putative | 0.0111 | 0.5406 | 0.9676 |
Entamoeba histolytica | protein kinase, putative | 0.0041 | 0.1812 | 0.3264 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0014 | 0.0433 | 0.042 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.1367 | 0.2463 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0032 | 0.1367 | 0.2463 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0433 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5406 | 0.539 |
Schistosoma mansoni | elongation factor 2 kinase | 0.0032 | 0.1367 | 0.1337 |
Echinococcus multilocularis | roundabout 2 | 0.0017 | 0.0604 | 0.06 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0029 | 0.1172 | 0.1142 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.02 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.5552 | 0.5821 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0014 | 0.0433 | 0.042 |
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0418 | 0.0405 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0014 | 0.0433 | 0.042 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0014 | 0.0433 | 0.042 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.0558 | 0.1006 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0038 | 0.1686 | 0.1657 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0273 | 0.0251 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0029 | 0.1172 | 0.12 |
Echinococcus granulosus | twitchin | 0.0016 | 0.0508 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Brugia malayi | Hr1 repeat family protein | 0.0014 | 0.0433 | 0.0399 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.5552 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0014 | 0.0433 | 0.0399 |
Echinococcus granulosus | Immunoglobulin | 0.0011 | 0.0273 | 0.0251 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.1812 | 0.1783 |
Entamoeba histolytica | protein kinase, putative | 0.0041 | 0.1812 | 0.3264 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0014 | 0.0433 | 0.042 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.5552 | 0.5821 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0604 | 0.06 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0057 | 0.2634 | 0.4745 |
Entamoeba histolytica | elongation factor-2 kinase, putative | 0.0032 | 0.1367 | 0.2463 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Schistosoma mansoni | elongation factor 2 kinase | 0.0032 | 0.1367 | 0.1337 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0014 | 0.0433 | 0.042 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.5552 | 0.5821 |
Trypanosoma brucei | myosin heavy chain kinase A, putative | 0.0111 | 0.5406 | 0.961 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0014 | 0.0433 | 0.0399 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0014 | 0.0433 | 0.042 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0024 | 0.0958 | 0.0974 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0029 | 0.1172 | 0.12 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.5552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0014 | 0.0433 | 0.0399 |
Trypanosoma brucei | myosin heavy chain kinase A, putative | 0.0111 | 0.5406 | 0.961 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0014 | 0.0433 | 0.042 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0014 | 0.0433 | 0.042 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0273 | 0.0239 |
Entamoeba histolytica | protein kinase, putative | 0.0014 | 0.0433 | 0.078 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0026 | 0.1047 | 0.5 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0014 | 0.0433 | 0.042 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0459 | 0.0425 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5552 | 1 |
Brugia malayi | MHCK/EF2 kinase domain family protein | 0.0111 | 0.5406 | 0.539 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.5552 | 0.5536 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.019 | 0.9513 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0026 | 0.1047 | 0.1068 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0041 | 0.1812 | 0.1783 |
Echinococcus multilocularis | nervana 2 | 0.0024 | 0.0958 | 0.0974 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0014 | 0.0433 | 0.0399 |
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Trichomonas vaginalis | AGC family protein kinase | 0.0014 | 0.0433 | 0.078 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.5552 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0057 | 0.2634 | 0.4745 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0024 | 0.0958 | 0.0974 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0273 | 0.0251 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0029 | 0.1172 | 0.2112 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0418 | 0.0405 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0604 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0433 | 0.0399 |
Echinococcus granulosus | eukaryotic elongation factor 2 kinase | 0.0111 | 0.5406 | 0.5667 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0014 | 0.0433 | 0.0399 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.1686 | 0.3038 |
Trichomonas vaginalis | AGC family protein kinase | 0.0014 | 0.0433 | 0.078 |
Brugia malayi | protein kinase C II. | 0.0014 | 0.0433 | 0.0399 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.019 | 0.9513 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0014 | 0.0433 | 0.042 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0433 | 0.0399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0433 | 0.0399 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.1367 | 0.2463 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0273 | 0.0239 |
Schistosoma mansoni | serine/threonine protein kinase | 0.02 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.019 | 0.9513 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.019 | 0.9513 | 0.9512 |
Trichomonas vaginalis | AGC family protein kinase | 0.0041 | 0.1812 | 0.3264 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0026 | 0.1047 | 0.5 |
Echinococcus multilocularis | eukaryotic elongation factor 2 kinase | 0.0111 | 0.5406 | 0.5667 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0012 | 0.0344 | 0.0619 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.019 | 0.9513 | 0.9512 |
Trypanosoma cruzi | myosin heavy chain kinase A, putative | 0.0111 | 0.5406 | 0.9676 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.5552 | 0.5536 |
Trichomonas vaginalis | AGC family protein kinase | 0.0014 | 0.0433 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0604 | 0.0571 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.5552 | 1 |
Toxoplasma gondii | AGC kinase | 0.0038 | 0.1686 | 0.5 |
Schistosoma mansoni | serine/threonine kinase | 0.0014 | 0.0433 | 0.0399 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0008 | 0.0124 | 0.009 |
Echinococcus granulosus | protein kinase C gamma type | 0.0014 | 0.0433 | 0.042 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.5552 | 0.5536 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0459 | 0.0425 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0014 | 0.0433 | 0.042 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5552 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0459 | 0.0447 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0032 | 0.1367 | 0.2463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.