Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0399 | 0.0399 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0025 | 0.1142 | 0.02 |
Brugia malayi | Fibronectin type III domain containing protein | 0.001 | 0.0239 | 0.0239 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0021 | 0.0926 | 0.0974 |
Trypanosoma brucei | polo-like protein kinase | 0.0099 | 0.5536 | 0.6797 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0012 | 0.0399 | 0.042 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0146 | 0.8337 | 0.8765 |
Trichomonas vaginalis | AGC family protein kinase | 0.0014 | 0.0525 | 0.0892 |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0399 | 0.0399 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.8948 | 0.8948 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0012 | 0.0399 | 0.0399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Trypanosoma cruzi | Protein kinase B | 0.0025 | 0.1142 | 0.02 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0012 | 0.0399 | 0.042 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0025 | 0.1142 | 0.1142 |
Giardia lamblia | Kinase, PLK | 0.0099 | 0.5536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0012 | 0.0399 | 0.0399 |
Trichomonas vaginalis | AGC family protein kinase | 0.0012 | 0.0399 | 0.0663 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0099 | 0.5536 | 0.5536 |
Brugia malayi | Hr1 repeat family protein | 0.0012 | 0.0399 | 0.0399 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0012 | 0.0399 | 0.042 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0012 | 0.0399 | 0.042 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0012 | 0.0399 | 0.042 |
Echinococcus granulosus | NDR protein kinase | 0.0012 | 0.0399 | 0.042 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Entamoeba histolytica | protein kinase, putative | 0.0034 | 0.1657 | 0.295 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0099 | 0.5536 | 0.5536 |
Onchocerca volvulus | 0.0143 | 0.8139 | 0.8557 | |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0021 | 0.0926 | 0.0974 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0012 | 0.0399 | 0.042 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0021 | 0.0926 | 0.0974 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0099 | 0.5536 | 0.5536 |
Schistosoma mansoni | nephrin | 0.0012 | 0.0385 | 0.0385 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0025 | 0.1142 | 0.12 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0156 | 0.8948 | 0.8948 |
Echinococcus multilocularis | nervana 2 | 0.0021 | 0.0926 | 0.0974 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0023 | 0.1016 | 0.1068 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0007 | 0.009 | 0.009 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Entamoeba histolytica | elongation factor-2 kinase, putative | 0.0038 | 0.1896 | 0.3383 |
Trichomonas vaginalis | AGC family protein kinase | 0.0012 | 0.0399 | 0.0663 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0013 | 0.0425 | 0.0447 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.7305 | 0.7305 |
Entamoeba histolytica | protein kinase, putative | 0.0012 | 0.0399 | 0.0663 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0012 | 0.0399 | 0.0399 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.1896 | 0.3383 |
Brugia malayi | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Schistosoma mansoni | tyrosine kinase | 0.0006 | 0.0052 | 0.0052 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0099 | 0.5536 | 0.5821 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0023 | 0.1016 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0012 | 0.0399 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0425 | 0.0425 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0034 | 0.1657 | 0.1657 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Echinococcus granulosus | protein kinase c iota type | 0.0012 | 0.0399 | 0.042 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0099 | 0.5536 | 0.673 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0475 | 0.0499 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0025 | 0.1142 | 0.12 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Echinococcus multilocularis | nervana 2 | 0.0021 | 0.0926 | 0.0974 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0239 | 0.0239 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0012 | 0.0399 | 0.042 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0038 | 0.1896 | 0.3383 |
Echinococcus granulosus | nervana 2 | 0.0021 | 0.0926 | 0.0974 |
Schistosoma mansoni | eukaryotic elongation factor 2 kinase (eef-2 kinase) | 0.0129 | 0.7305 | 0.7305 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0166 | 0.9512 | 0.9512 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0571 | 0.0571 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0038 | 0.1896 | 0.3383 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0025 | 0.1142 | 0.1142 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0012 | 0.0399 | 0.0399 |
Schistosoma mansoni | cell adhesion molecule | 0.0013 | 0.0425 | 0.0425 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0012 | 0.0399 | 0.042 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0011 | 0.031 | 0.05 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0012 | 0.0399 | 0.042 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0012 | 0.0399 | 0.042 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0012 | 0.0399 | 0.042 |
Brugia malayi | Protein kinase domain containing protein | 0.0166 | 0.9512 | 0.9512 |
Brugia malayi | Protein kinase domain containing protein | 0.0036 | 0.1783 | 0.1783 |
Schistosoma mansoni | elongation factor 2 kinase | 0.0038 | 0.1896 | 0.1896 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0038 | 0.1896 | 0.3383 |
Brugia malayi | protein kinase C II. | 0.0012 | 0.0399 | 0.0399 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.1783 | 0.3179 |
Trypanosoma cruzi | myosin heavy chain kinase A, putative | 0.0129 | 0.7305 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.1896 | 0.3383 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Trypanosoma cruzi | myosin heavy chain kinase A, putative | 0.0129 | 0.7305 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.2609 | 0.4679 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0239 | 0.0251 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0036 | 0.1783 | 0.1783 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0099 | 0.5536 | 0.7188 |
Leishmania major | myosin heavy chain kinase a-like protein | 0.0129 | 0.7305 | 1 |
Trypanosoma brucei | myosin heavy chain kinase A, putative | 0.0129 | 0.7305 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0099 | 0.5536 | 0.7188 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0012 | 0.0399 | 0.042 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0012 | 0.0399 | 0.0399 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0025 | 0.1142 | 0.2012 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0012 | 0.0399 | 0.0399 |
Echinococcus granulosus | nervana 2 | 0.0021 | 0.0926 | 0.0974 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0034 | 0.1657 | 0.1657 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0099 | 0.5536 | 0.5821 |
Schistosoma mansoni | serine/threonine kinase | 0.0012 | 0.0399 | 0.0399 |
Toxoplasma gondii | AGC kinase | 0.0034 | 0.1657 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0036 | 0.1783 | 0.3179 |
Echinococcus granulosus | Immunoglobulin | 0.001 | 0.0239 | 0.0251 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0012 | 0.0399 | 0.042 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0571 | 0.0571 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.0385 | 0.0405 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0399 | 0.0399 |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0399 | 0.0399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0174 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0166 | 0.9512 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0166 | 0.9512 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0239 | 0.0239 |
Schistosoma mansoni | elongation factor 2 kinase | 0.0038 | 0.1896 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Brugia malayi | MHCK/EF2 kinase domain family protein | 0.0129 | 0.7305 | 0.7305 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0012 | 0.0399 | 0.042 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0012 | 0.0399 | 0.042 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0166 | 0.9512 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0571 | 0.06 |
Entamoeba histolytica | protein kinase, putative | 0.0036 | 0.1783 | 0.3179 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0571 | 0.06 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.2609 | 0.4679 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0166 | 0.9512 | 0.9512 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0099 | 0.5536 | 0.5821 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0023 | 0.1016 | 0.1068 |
Entamoeba histolytica | protein kinase 2, putative | 0.0023 | 0.1016 | 0.1783 |
Echinococcus granulosus | eukaryotic elongation factor 2 kinase | 0.0129 | 0.7305 | 0.768 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0166 | 0.9512 | 0.9512 |
Schistosoma mansoni | kinase | 0.0051 | 0.2685 | 0.2685 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0239 | 0.0239 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0023 | 0.1016 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0239 | 0.0251 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.0385 | 0.0405 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0025 | 0.1142 | 0.2012 |
Trypanosoma brucei | myosin heavy chain kinase A, putative | 0.0129 | 0.7305 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0023 | 0.1016 | 0.1068 |
Echinococcus granulosus | defective proboscis extension response | 0.001 | 0.0239 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Echinococcus multilocularis | eukaryotic elongation factor 2 kinase | 0.0129 | 0.7305 | 0.768 |
Trichomonas vaginalis | AGC family protein kinase | 0.0012 | 0.0399 | 0.0663 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0166 | 0.9512 | 0.9512 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0099 | 0.5536 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0021 | 0.0926 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0239 | 0.0239 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.001 | 0.0239 | 0.0239 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1896 | 0.3383 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0099 | 0.5536 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0012 | 0.0399 | 0.042 |
Schistosoma mansoni | atypical protein kinase C | 0.0012 | 0.0399 | 0.0399 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.001 | 0.0239 | 0.0251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.