TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.39 | Formula: C19H22N2O2
H donors: 0 H acceptors: 2 LogP: 2.14 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CCC1=O)C(=O)Cc1ccc2c(c1)cccc2
InChi: 1S/C19H22N2O2/c1-2-20-11-12-21(10-9-18(20)22)19(23)14-15-7-8-16-5-3-4-6-17(16)13-15/h3-8,13H,2,9-12,14H2,1H3
InChiKey: NPFJVTLCXFVRPL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.0238	0.025
Schistosoma mansoni	hypothetical protein	0.0011	0.0238	0.0238
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.0238	0.025
Schistosoma mansoni	growth hormone secretagogue receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0425	0.0425
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.0238	0.025
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0192	0.9512	0.9512
Trypanosoma brucei	myosin heavy chain kinase A, putative	0.0112	0.5407	0.9655
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0026	0.1016	0.1068
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0011	0.0238	0.0238
Brugia malayi	protein kinase C II.	0.0014	0.0399	0.0399
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Brugia malayi	RE15519p	0.0011	0.0238	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0238	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0202	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.0238	0.025
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0238	0.025
Entamoeba histolytica	protein kinase, putative	0.0033	0.1342	0.1835
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0238	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Onchocerca volvulus		0.0011	0.0238	0.025
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0014	0.0399	0.042
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0238	0.025
Entamoeba histolytica	protein kinase, putative	0.0041	0.1783	0.2694
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.0238	0.025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Echinococcus granulosus	protein kinase c epsilon type	0.0014	0.0399	0.042
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0525	0.0412
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.5536	0.5536
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0238	0.025
Schistosoma mansoni	serine/threonine kinase	0.0014	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0239	0.0239
Schistosoma mansoni	atypical protein kinase C	0.0014	0.0399	0.0399
Brugia malayi	follicle stimulating hormone receptor	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	nervana 2	0.0025	0.0926	0.0974
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus granulosus	nervana 2	0.0025	0.0926	0.0974
Entamoeba histolytica	protein kinase 2, putative	0.0026	0.1016	0.12
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0192	0.9512	1
Giardia lamblia	Kinase, PLK	0.0114	0.5536	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0029	0.1142	0.1142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	serotonin receptor	0.0011	0.0238	0.025
Echinococcus granulosus	serine:threonine protein kinase N2	0.0014	0.0399	0.042
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0238	0.025
Leishmania major	myosin heavy chain kinase a-like protein	0.0112	0.5407	0.9691
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0238	0.025
Brugia malayi	ORL1-like opioid receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Trypanosoma cruzi	myosin heavy chain kinase A, putative	0.0112	0.5407	0.9713
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0425	0.0447
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.5536	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.0238	0.0238
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0014	0.0399	0.042
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0238	0.025
Brugia malayi	putative neuropeptide receptor NPR1	0.0011	0.0238	0.0238
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0238	0.025
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0014	0.0399	0.0399
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Trypanosoma brucei	myosin heavy chain kinase A, putative	0.0112	0.5407	0.9655
Echinococcus multilocularis	protein kinase c iota type	0.0014	0.0399	0.042
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0239	0.0239
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	neuroglian	0.0014	0.0385	0.0405
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0238	0.0238
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.0926	0.0974
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein, conserved	0.0033	0.1342	0.1835
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Echinococcus multilocularis	somatostatin receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0041	0.1783	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0239	0.0239
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0014	0.0399	0.042
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.2609	0.4399
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	roundabout 2	0.0018	0.0571	0.06
Schistosoma mansoni	amine GPCR	0.0011	0.0238	0.0238
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Echinococcus granulosus	protein kinase C gamma type	0.0014	0.0399	0.042
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0571	0.0571
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0399	0.0399
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0014	0.0399	0.0399
Brugia malayi	Dopamine receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	allatostatin A receptor	0.0011	0.0238	0.025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Brugia malayi	G-protein coupled receptor	0.0011	0.0238	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0039	0.1657	0.1657
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0239	0.0251
Schistosoma mansoni	myosin xvIII	0.0011	0.0238	0.0238
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0238	0.025
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0202	1	1
Entamoeba histolytica	elongation factor-2 kinase, putative	0.0033	0.1342	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	serotonin receptor	0.0011	0.0238	0.025
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.0926	0.0974
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Echinococcus granulosus	serotonin receptor	0.0011	0.0238	0.025
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0192	0.9512	0.9512
Brugia malayi	hypothetical protein	0.0011	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.0238	0.025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0238	0.025
Onchocerca volvulus		0.0165	0.8139	0.8557
Echinococcus granulosus	orexin receptor type 2	0.0011	0.0238	0.025
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0014	0.0399	0.042
Echinococcus granulosus	serine threonine protein kinase nrc	0.0026	0.1016	0.1068
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0014	0.0399	0.042
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0014	0.0399	0.0399
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0026	0.1016	0.5
Schistosoma mansoni	opsin-like receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0181	0.8948	0.8948
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.5536	0.5536
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Brugia malayi	sulfakinin receptor protein	0.0011	0.0238	0.0238
Schistosoma mansoni	kinase	0.0059	0.2685	0.2685
Brugia malayi	G-protein coupled receptor	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein, conserved	0.0033	0.1342	0.1835
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0238	0.025
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.0238	0.025
Echinococcus granulosus	nervana 2	0.0025	0.0926	0.0974
Onchocerca volvulus		0.0011	0.0238	0.025
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0239	0.0239
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Schistosoma mansoni	amine GPCR	0.0011	0.0238	0.0238
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0238	0.025
Brugia malayi	Serotonin receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.0926	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0026	0.1016	0.1068
Schistosoma mansoni	opsin-like receptor	0.0011	0.0238	0.0238
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0239	0.0251
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.0238	0.025
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.0238	0.025
Schistosoma mansoni	hypothetical protein	0.0011	0.0238	0.0238
Brugia malayi	Dopamine receptor protein 1	0.0011	0.0238	0.0238
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.0238	0.0238
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0112	0.5407	0.5407
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0041	0.1783	0.1783
Brugia malayi	p70 ribosomal S6 kinase beta	0.0039	0.1657	0.1657
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0239	0.0239
Schistosoma mansoni	amine GPCR	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	hypothetical protein	0.0011	0.0238	0.025
Brugia malayi	Protein kinase domain containing protein	0.0192	0.9512	0.9512
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0011	0.0238	0.025
Trypanosoma brucei	polo-like protein kinase	0.0114	0.5536	1
Brugia malayi	GnHR receptor homolog	0.0011	0.0238	0.0238
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.0238	0.0238
Entamoeba histolytica	protein kinase, putative	0.0039	0.1657	0.2449
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0571	0.0571
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.5536	0.5821
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Onchocerca volvulus		0.0011	0.0238	0.025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0425	0.0425
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0014	0.0399	0.0399
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0238	0.025
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.5536	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0014	0.0399	0.042
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.0238	0.025
Onchocerca volvulus		0.0011	0.0238	0.025
Echinococcus multilocularis	sex peptide receptor	0.0011	0.0238	0.025
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Brugia malayi	Serotonin receptor	0.0011	0.0238	0.0238
Brugia malayi	Dopamine receptor protein 2	0.0011	0.0238	0.0238
Echinococcus multilocularis	eukaryotic elongation factor 2 kinase	0.0112	0.5407	0.5684
Brugia malayi	larval opioid receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0014	0.0399	0.0399
Brugia malayi	Fibronectin type III domain containing protein	0.0011	0.0239	0.0239
Brugia malayi	Hr1 repeat family protein	0.0014	0.0399	0.0399
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.9512	0.9512
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0192	0.9512	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	tyrosine kinase	0.0007	0.0052	0.0052
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0192	0.9512	0.9512
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	eukaryotic elongation factor 2 kinase (eef-2 kinase)	0.0112	0.5407	0.5407
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.0238	0.025
Toxoplasma gondii	AGC kinase	0.0039	0.1657	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.0238	0.025
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0011	0.0238	0.0238
Echinococcus granulosus	NDR protein kinase	0.0014	0.0399	0.042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0011	0.0238	0.0238
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.2609	0.4399
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.5536	0.5821
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0014	0.0399	0.042
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Schistosoma mansoni	nephrin	0.0014	0.0385	0.0385
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0238	0.025
Schistosoma mansoni	histamine h1 receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0238	0.025
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0238	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0014	0.0399	0.042
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0026	0.1016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0238	0.0238
Trypanosoma cruzi	Protein kinase B	0.0029	0.1142	0.0279
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.0238	0.025
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.0238	0.025
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.0238	0.025
Entamoeba histolytica	protein kinase, putative	0.0033	0.1342	0.1835
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.5536	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	neuropeptide f receptor 76f	0.0011	0.0238	0.0238
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.5536	0.5536
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	elongation factor 2 kinase	0.0033	0.1342	0.1342
Echinococcus multilocularis	serine threonine protein kinase	0.0014	0.0399	0.042
Echinococcus multilocularis	protein kinase c epsilon type	0.0014	0.0399	0.042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Onchocerca volvulus		0.0011	0.0238	0.025
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0238	0.0238
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0238	0.025
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0238	0.025
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.0238	0.0238
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0238	0.0238
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0011	0.0238	0.0238
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0239	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0399	0.0399
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0238	0.025
Brugia malayi	G protein-coupled receptor F59B2.13	0.0011	0.0238	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0399	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0239	0.0239
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0011	0.0238	0.0238
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0008	0.009	0.009
Echinococcus granulosus	twitchin	0.0016	0.0475	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0029	0.1142	0.1445
Echinococcus granulosus	fmrfamide receptor	0.0011	0.0238	0.025
Brugia malayi	neuropeptide F receptor	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	amine GPCR	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0238	0.0238
Entamoeba histolytica	hypothetical protein, conserved	0.0033	0.1342	0.1835
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	hypothetical protein	0.0011	0.0238	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0399	0.0171
Schistosoma mansoni	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	eukaryotic elongation factor 2 kinase	0.0112	0.5407	0.5684
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0011	0.0238	0.0238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0181	0.8948	0.8948
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0399	0.0171
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.5536	0.5821
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0029	0.1142	0.1445
Echinococcus granulosus	roundabout 2	0.0018	0.0571	0.06
Entamoeba histolytica	hypothetical protein	0.0033	0.1342	0.1835
Trypanosoma cruzi	myosin heavy chain kinase A, putative	0.0112	0.5407	0.9713
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.0238	0.025
Echinococcus granulosus	Protein kinase C brain isozyme	0.0014	0.0399	0.042
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	protein kinase c iota type	0.0014	0.0399	0.042
Schistosoma mansoni	opsin-like receptor	0.0011	0.0238	0.0238
Brugia malayi	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0238	0.025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Brugia malayi	MHCK/EF2 kinase domain family protein	0.0112	0.5407	0.5407
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0029	0.1142	0.0279
Schistosoma mansoni	serine/threonine-protein kinase	0.0029	0.1142	0.1142
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0238	0.0238
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0238	0.0238
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0238	0.025
Schistosoma mansoni	amine GPCR	0.0011	0.0238	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0399	0.0399
Echinococcus multilocularis	rac serine:threonine kinase	0.0029	0.1142	0.12
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Onchocerca volvulus		0.0011	0.0238	0.025
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0011	0.0238	0.0238
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.0238	0.025
Echinococcus granulosus	neuroglian	0.0014	0.0385	0.0405
Trichomonas vaginalis	AGC family protein kinase	0.0041	0.1783	0.2819
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0011	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	sex peptide receptor	0.0011	0.0238	0.025
Brugia malayi	neuropeptide F receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0239	0.0251
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.0238	0.025
Echinococcus granulosus	Immunoglobulin	0.0011	0.0239	0.0251
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0238	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0399	0.0399
Entamoeba histolytica	protein kinase, putative	0.0041	0.1783	0.2694
Schistosoma mansoni	elongation factor 2 kinase	0.0033	0.1342	0.1342
Echinococcus multilocularis	nervana 2	0.0025	0.0926	0.0974
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.0926	0.0974
Onchocerca volvulus		0.0011	0.0238	0.025
Brugia malayi	putative neuropeptide receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.0238	0.025
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0014	0.0399	0.042
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0238	0.025
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0238	0.025
Brugia malayi	Melatonin receptor type 1A	0.0011	0.0238	0.0238
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0238	0.025
Echinococcus granulosus	somatostatin receptor	0.0011	0.0238	0.025
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.5536	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.0238	0.025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.0238	0.025
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.5536	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0239	0.0239
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0238	0.025
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0011	0.0238	0.025
Onchocerca volvulus		0.0011	0.0238	0.025
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0192	0.9512	1
Brugia malayi	AKH receptor	0.0011	0.0238	0.0238
Echinococcus granulosus	serine/threonine protein kinase	0.0029	0.1142	0.12
Onchocerca volvulus		0.0011	0.0238	0.025
Brugia malayi	G protein-coupled receptor	0.0011	0.0238	0.0238
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.0238	0.025
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0014	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Schistosoma mansoni	adenoreceptor	0.0011	0.0238	0.0238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0238	0.0238
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.0238	0.025
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.0238	0.025
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0014	0.0399	0.042
Onchocerca volvulus	Tyrosine kinase homolog	0.0169	0.8337	0.8765
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0238	0.0238

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 814762