Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.1276 | 0.1498 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.124 | 0.9717 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0782 | 0.6125 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0255 | 0.1996 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0782 | 0.0782 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0782 | 0.6125 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0782 | 0.0918 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.036 | 0.2818 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0782 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1276 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0782 | 0.0782 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0255 | 0.0299 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0782 | 0.0782 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1276 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0782 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0782 | 0.0918 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0128 | 0.852 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0782 | 0.6125 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0782 | 0.0782 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0128 | 0.852 | 0.852 |
Onchocerca volvulus | 0.0021 | 0.0782 | 0.6125 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Echinococcus granulosus | lamin | 0.0027 | 0.1276 | 0.1498 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0782 | 0.0782 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0782 | 0.6125 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0782 | 0.6125 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0656 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0782 | 0.6125 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0782 | 0.0918 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0782 | 0.0782 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1276 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0782 | 0.0918 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0011 | 0.0084 | 0.0084 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.1276 | 0.1276 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0219 | 0.1713 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0782 | 0.0782 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0782 | 0.0918 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0084 | 0.0656 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0782 | 0.6125 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | nuclear receptor RXR | 0.0011 | 0.0084 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1276 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0782 | 0.0782 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0782 | 0.6125 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1276 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0782 | 0.6125 |
Onchocerca volvulus | 0.0027 | 0.1276 | 1 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0084 | 0.0656 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0782 | 0.0782 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0782 | 0.6125 |
Onchocerca volvulus | 0.0027 | 0.1276 | 1 | |
Schistosoma mansoni | lamin | 0.0027 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0782 | 0.6125 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.852 | 0.852 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0782 | 0.6125 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0782 | 0.6125 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.036 | 0.2818 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0782 | 0.6125 |
Schistosoma mansoni | lamin | 0.0027 | 0.1276 | 0.1276 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0782 | 0.0782 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0782 | 0.0782 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.1276 | 0.1276 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0219 | 0.1713 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0782 | 0.6125 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.1276 | 0.1498 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0782 | 0.0918 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0255 | 0.0255 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0782 | 0.6125 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0011 | 0.0084 | 0.0656 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0782 | 0.0782 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0011 | 0.0084 | 0.0098 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0011 | 0.0084 | 0.0084 |
Echinococcus multilocularis | musashi | 0.0027 | 0.1276 | 0.1276 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0782 | 0.0918 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.