Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0027 | 0.0052 | 0.0209 |
Leishmania major | pteridine reductase 1 | 0.0027 | 0.0052 | 0.4316 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.4316 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0038 | 0.0121 | 0.8896 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0121 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0403 | 0.2504 | 1 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0027 | 0.0052 | 0.0209 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0038 | 0.0121 | 0.8896 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0038 | 0.0121 | 0.8896 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0403 | 0.2504 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0027 | 0.0052 | 0.384 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0038 | 0.0121 | 0.8896 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.4316 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0038 | 0.0121 | 0.8896 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0027 | 0.0052 | 0.0052 |
Trichomonas vaginalis | hypothetical protein | 0.0403 | 0.2504 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0136 | 0.0136 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Leishmania major | oxidoreductase-like protein | 0.0027 | 0.0052 | 0.4316 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0027 | 0.0052 | 0.0209 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0403 | 0.2504 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0403 | 0.2504 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0403 | 0.2504 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Loa Loa (eye worm) | oxidoreductase | 0.0027 | 0.0052 | 0.4316 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0038 | 0.0121 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0027 | 0.0052 | 0.384 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0403 | 0.2504 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.0121 | 0.0485 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0027 | 0.0052 | 0.0209 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0027 | 0.0052 | 0.0209 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0136 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0027 | 0.0052 | 0.4316 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0027 | 0.0052 | 0.0209 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0136 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0027 | 0.0052 | 0.0209 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0038 | 0.0121 | 0.8896 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | oxidoreductase | 0.0027 | 0.0052 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0121 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.4316 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0027 | 0.0052 | 0.4316 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0038 | 0.0121 | 0.8896 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0038 | 0.0121 | 0.8896 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Trypanosoma brucei | pteridine reductase 1 | 0.0027 | 0.0052 | 0.4316 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.0121 | 0.0485 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0403 | 0.2504 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0038 | 0.0121 | 0.0121 |
Onchocerca volvulus | 0.0027 | 0.0052 | 0.5 | |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.4316 |
Onchocerca volvulus | 0.0027 | 0.0052 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0121 | 0.0485 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0027 | 0.0052 | 0.384 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0136 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0403 | 0.2504 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0027 | 0.0052 | 0.0209 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0121 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0027 | 0.0052 | 0.0209 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0027 | 0.0052 | 0.4316 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0136 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0027 | 0.0052 | 0.4316 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0027 | 0.0052 | 0.0052 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0027 | 0.0052 | 0.0209 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0038 | 0.0121 | 0.8896 |
Schistosoma mansoni | dihydropteridine reductase | 0.0027 | 0.0052 | 0.384 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0027 | 0.0052 | 0.4316 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0121 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0027 | 0.0052 | 0.4316 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0027 | 0.0052 | 0.384 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0027 | 0.0052 | 0.4316 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0027 | 0.0052 | 0.0209 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0038 | 0.0121 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.