Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0803 | 0.0149 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.6532 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.4724 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.4724 | 0.4001 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.6311 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0032 | 0.6311 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.4724 | 0.4263 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0032 | 0.6311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4586 | 0.42 |
Schistosoma mansoni | rotamase | 0.0033 | 0.6532 | 0.3427 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0032 | 0.6311 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.4724 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.6532 | 0.6057 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.6311 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.6532 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.4724 | 0.4349 |
Echinococcus multilocularis | lamin | 0.0027 | 0.4724 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.4724 | 0.4263 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1206 | 0.058 |
Echinococcus granulosus | lamin | 0.0027 | 0.4724 | 0.4263 |
Onchocerca volvulus | 0.0027 | 0.4724 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.6532 | 0.6285 |
Onchocerca volvulus | 0.0027 | 0.4724 | 0.5 | |
Echinococcus granulosus | expressed protein | 0.0033 | 0.6532 | 0.6229 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.4724 | 0.4349 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0032 | 0.6311 | 1 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.6532 | 0.6229 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.4724 | 0.4349 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.001 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.4724 | 0.4001 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.