Detailed information for compound 819599

Basic information

Technical information
  • TDR Targets ID: 819599
  • Name: (Z)-4-[(4-ethoxyphenyl)amino]-4-oxobut-2-enoi c acid
  • MW: 235.236 | Formula: C12H13NO4
  • H donors: 2 H acceptors: 3 LogP: 1.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)C=CC(=O)O
  • InChi: 1S/C12H13NO4/c1-2-17-10-5-3-9(4-6-10)13-11(14)7-8-12(15)16/h3-8H,2H2,1H3,(H,13,14)(H,15,16)/b8-7-
  • InChiKey: LMTIUWRMRAZPEN-FPLPWBNLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-4-[(4-ethoxyphenyl)amino]-4-oxo-but-2-enoic acid
  • (Z)-4-[(4-ethoxyphenyl)amino]-4-keto-but-2-enoic acid
  • STK094085
  • ARONIS021167
  • BIM-0016306.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0087 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0007 0.7552
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0021 0.0009 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Trichomonas vaginalis hypothetical protein 0.0021 0.0009 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.3119 0.5596 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0087 0.0156
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0087 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Schistosoma mansoni discoidin domain receptor 0.0021 0.0009 0.1003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0087 1
Schistosoma mansoni hypothetical protein 0.0021 0.0009 0.1003
Echinococcus granulosus discoidin domain containing receptor 2 0.0021 0.0009 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0007 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0007 0.5
Echinococcus multilocularis mitogen activated protein kinase 11 0.3119 0.5596 1
Brugia malayi P38 map kinase family protein 2 0.3119 0.5596 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.0012
Toxoplasma gondii F5/8 type C domain-containing protein 0.0021 0.0009 0.0009
Schistosoma mansoni septate junction protein 0.0021 0.0009 0.1003
Schistosoma mansoni btb and poz domain-containing protein 0.0021 0.0009 0.1003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0007 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.3119 0.5596 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.0021 0.0009 0.0009
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0009 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0151 0.0243 0.0236
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0021 0.0009 0.0016
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.3119 0.5596 1
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0021 0.0009 0.5
Brugia malayi Protein kinase domain containing protein 0.0172 0.0281 0.0491
Toxoplasma gondii PA14 domain-containing protein 0.0021 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0007 0.0012
Toxoplasma gondii F5/8 type C domain-containing protein 0.0021 0.0009 0.0009
Echinococcus multilocularis discoidin domain containing receptor 2 0.0021 0.0009 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0276 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Echinococcus granulosus discoidin domain receptor 0.017 0.0276 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Schistosoma mansoni dock 0.0021 0.0009 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.556 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0002
Echinococcus granulosus discoidin domain containing receptor 2 0.0021 0.0009 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0007 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Onchocerca volvulus 0.0172 0.0281 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0021 0.0009 0.0016
Brugia malayi follicle stimulating hormone receptor 0.0247 0.0416 0.0732
Toxoplasma gondii exonuclease III APE 0.002 0.0007 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.3119 0.5596 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0087 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0007 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.0021 0.0009 0.0016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.0416 0.041
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0021 0.0009 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0087 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.3119 0.5596 1
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0009 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0087 1
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.3119 0.5596 0.5593
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.556 1 1
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.556 1 1
Plasmodium vivax LCCL domain-containing protein 0.0021 0.0009 1
Echinococcus granulosus mitogen activated protein kinase 14 0.3119 0.5596 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0087 0.0156
Echinococcus multilocularis discoidin domain containing receptor 2 0.0021 0.0009 0.0016
Echinococcus granulosus mitogen activated protein kinase 11 0.3119 0.5596 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.3119 0.5596 1
Plasmodium vivax LCCL domain-containing protein 0.0021 0.0009 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.3119 0.5596 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0007 0.0012
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0021 0.0009 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0009 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.0012
Toxoplasma gondii hypothetical protein 0.556 1 1
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0757
Loa Loa (eye worm) hypothetical protein 0.0151 0.0243 0.0236
Echinococcus multilocularis discoidin domain receptor 0.0021 0.0009 0.0016
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0021 0.0009 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0021 0.0009 1
Schistosoma mansoni discoidin domain receptor 0.0021 0.0009 0.1003
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0021 0.0009 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0087 0.0087
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0007 0.0012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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