Detailed view for Smp_135520

Basic information

TDR Targets ID: 289374
Schistosoma mansoni, dock
Source Database / ID:  GeneDB

pI: 7.7715 | Length (AA): 2485 | MW (Da): 283140 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00754   F5/8 type C domain
PF06920   Dock homology region 2
PF14429   C2 domain in Dock180 and Zizimin proteins

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0005085   guanyl-nucleotide exchange factor activity  
GO:0051020   GTPase binding  
GO:0007155   cell adhesion  
GO:0007264   small GTPase mediated signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 84 5y4m (A) 99 183 37.00 0 0.79 0.428903 -0.29
3 106 2wn3 (A) 77 180 40.00 0.00000000012 0.75 0.324851 1.04
10 256 1sdd (B) 1947 2180 30.00 0 1 0.207496 0.95
93 256 3bn6 (A) 13 158 38.00 0 0.96 0.306096 -0.11
699 1557 1z3h (A) 88 934 11.00 0 0.8 0.363774 0.36
973 1969 4hzk (A) 40 1036 12.00 0 0.99 0.469307 0.41
1066 1244 3l4c (A) 425 609 20.00 0.0000000015 0.95 0.238532 0.12
1976 2465 3b13 (A) 1196 1622 17.00 0 1 0.126683 0.64
2172 2460 3vhl (A) 1792 2062 48.00 0 1 0.629298 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126666)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0280223   hypothetical protein
Dictyostelium discoideum DDB_G0270214   galactose-binding domain-containing protein
Dictyostelium discoideum DDB_G0274309   discoidin-like protein
Dictyostelium discoideum DDB_G0273067   discoidin I, D chain
Dictyostelium discoideum DDB_G0270212   galactose-binding domain-containing protein
Dictyostelium discoideum DDB_G0273919   discoidin I, A chain
Dictyostelium discoideum DDB_G0292552   discoidin II
Dictyostelium discoideum DDB_G0273887   discoidin I, D chain
Dictyostelium discoideum DDB_G0273063   discoidin I, A chain
Dictyostelium discoideum DDB_G0273885   discoidin I, C chain and B chain
Dictyostelium discoideum DDB_G0273065   discoidin I, C chain and B chain
Echinococcus granulosus EgrG_000796300   Coagulation factor 5 8 type C terminal
Echinococcus multilocularis EmuJ_000796300   Coagulation factor 5 8 type, C terminal
Echinococcus multilocularis EmuJ_000568900   dedicator of cytokinesis protein
Homo sapiens ENSG00000140545   milk fat globule-EGF factor 8 protein
Homo sapiens ENSG00000185010   coagulation factor VIII, procoagulant component
Homo sapiens ENSG00000164176   EGF-like repeats and discoidin I-like domains 3
Homo sapiens 2153   coagulation factor V (proaccelerin, labile factor)
Mus musculus ENSMUSG00000026579   coagulation factor V
Mus musculus ENSMUSG00000030605   milk fat globule-EGF factor 8 protein
Mus musculus ENSMUSG00000031196   coagulation factor VIII
Mus musculus ENSMUSG00000034488   EGF-like repeats and discoidin I-like domains 3
Schistosoma japonicum Sjp_0098000   Retinoschisin precursor, putative
Schistosoma japonicum Sjp_0103300   IPR010703,Dedicator of cytokinesis,domain-containing
Schistosoma japonicum Sjp_0087020   IPR000421,Coagulation factor 5/8 type, C-terminal;IPR008979,Galactose-binding like,domain-containing
Schistosoma mansoni Smp_135520   dock
Schmidtea mediterranea mk4.001723.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens coagulation factor VIII, procoagulant component Compounds References
Homo sapiens coagulation factor V (proaccelerin, labile factor) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.021 0.6221 1
0.0305 0.5261 1
0.0254 0.3124 0.3675
0.0121 0.5205 0.6431
0.007 0.4079 0.4075
0.0112 1 1
0.0257 0.601 1
0.02 0.3008 0.3297
0.0046 0.4809 1
0.0229 0.4079 1
0.0112 1 1
0.0254 0.3124 0.3675
0.0283 0.4079 1
0.0111 1 1
0.0115 1 1
0.0254 0.3124 0.3675
0.0139 0.2966 0.2966
0.0112 1 1
0.00833648 1 1
0.0254 0.3124 0.3675
0.0121 0.5205 0.6431
0.0111 0.3516 0.3516
0.0121 0.5205 0.6431
0.0113 1 1
0.0134 0.3866 0.3856
0.0254 0.3124 0.3675
0.007 0.4079 1
0.0111 0.3516 0.3516
0.0115 1 1
0.0092 1 1
0.0111 1 1
0.0305 0.5261 1
0.007 0.2571 0.3192
0.0058 0.5947 1
0.0234 0.5952 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_135520 (Schistosoma mansoni), dock
Title for this comment
Comment