Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0183 | 0.0497 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0183 | 0.0497 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0183 | 0.0497 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0183 | 0.0497 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0414 | 0.2579 | 0.2494 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0183 | 0.0497 | 0.0497 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0183 | 0.0497 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1237 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1182 | 0.9503 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0414 | 0.2579 | 0.2579 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0183 | 0.0497 | 0.0388 |
Trypanosoma brucei | glucosidase, putative | 0.0183 | 0.0497 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0414 | 0.2579 | 0.2332 |
Schistosoma mansoni | alpha glucosidase | 0.0183 | 0.0497 | 0.0026 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1237 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0181 | 0.0487 | 0.9806 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0414 | 0.2579 | 0.2579 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0183 | 0.0497 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0414 | 0.2579 | 0.2494 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0183 | 0.0497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0113 | 0.0113 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.014 | 0.0113 | 0.227 |
Schistosoma mansoni | alpha-glucosidase | 0.1182 | 0.9503 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0183 | 0.0497 | 0.0388 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.014 | 0.0113 | 0.227 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.014 | 0.0113 | 0.5 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.014 | 0.0113 | 0.227 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.014 | 0.0113 | 0.0113 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1237 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0183 | 0.0497 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0183 | 0.0497 | 0.0497 |
Onchocerca volvulus | 0.0892 | 0.6886 | 1 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0183 | 0.0497 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0183 | 0.0497 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0183 | 0.0497 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0181 | 0.0487 | 0.9806 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0183 | 0.0497 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0414 | 0.2579 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0183 | 0.0497 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1237 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0183 | 0.0497 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0183 | 0.0497 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 1.5 % | Dissociation of [3H]-N6-cyclohexyladenosine ([3H]-CHA) from CHO-K1 membrane expressing human adenosine A1 receptor after treament with allosteric enhancer at 100 microM and (R)-PIA | ChEMBL. | 12723950 |
Activity (binding) | = 1.5 % | Dissociation of [3H]-N6-cyclohexyladenosine ([3H]-CHA) from CHO-K1 membrane expressing human adenosine A1 receptor after treament with allosteric enhancer at 100 microM and (R)-PIA | ChEMBL. | 12723950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.