Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0572 | 0.2452 | 0.5222 |
Loa Loa (eye worm) | AUR protein kinase | 0.031 | 0.129 | 0.2744 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.058 | 0.2487 | 0.5295 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.031 | 0.129 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.031 | 0.129 | 0.2744 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0345 | 0.1448 | 0.308 |
Leishmania major | protein kinase, putative | 0.031 | 0.129 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.031 | 0.129 | 0.2744 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0345 | 0.1448 | 0.308 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0145 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0061 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0072 | 0.0149 |
Echinococcus multilocularis | geminin | 0.0176 | 0.0698 | 0.1482 |
Brugia malayi | Protein kinase domain containing protein | 0.0345 | 0.1448 | 0.308 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0241 | 0.0985 | 0.2095 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.2272 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.2272 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0129 | 0.0487 | 0.1034 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0026 | 0.003 | 0.0061 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.031 | 0.129 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0572 | 0.2452 | 0.5222 |
Entamoeba histolytica | protein kinase domain containing protein | 0.031 | 0.129 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.058 | 0.2487 | 0.5295 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0145 | 0.0305 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.031 | 0.129 | 0.2744 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.0698 | 0.1485 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1077 | 0.4696 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0129 | 0.0487 | 0.1034 |
Entamoeba histolytica | protein kinase, putative | 0.031 | 0.129 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0129 | 0.0487 | 0.1034 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1077 | 0.4696 | 1 |
Schistosoma mansoni | nephrin | 0.0025 | 0.0024 | 0.0051 |
Entamoeba histolytica | protein kinase , putative | 0.031 | 0.129 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.031 | 0.129 | 0.2746 |
Schistosoma mansoni | tyrosine kinase | 0.0572 | 0.2452 | 0.5222 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0052 | 0.0108 |
Echinococcus multilocularis | aurora kinase A | 0.031 | 0.129 | 0.2744 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0129 | 0.0487 | 0.1034 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.002 | 0.0002 | 0.0003 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0052 | 0.0108 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0145 | 0.0305 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.2272 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0026 | 0.003 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0072 | 0.0153 |
Echinococcus multilocularis | 0.0333 | 0.1392 | 0.2961 | |
Echinococcus granulosus | insulin receptor | 0.0345 | 0.1448 | 0.308 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1077 | 0.4696 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0305 | 0.1269 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.031 | 0.129 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.031 | 0.129 | 0.2744 |
Trypanosoma brucei | aurora B kinase | 0.031 | 0.129 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0129 | 0.0487 | 0.1034 |
Giardia lamblia | Aurora kinase | 0.031 | 0.129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0052 | 0.0108 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0052 | 0.0108 |
Schistosoma mansoni | tyrosine kinase | 0.058 | 0.2487 | 0.5296 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.031 | 0.129 | 0.2744 |
Echinococcus granulosus | twitchin | 0.0028 | 0.0037 | 0.0076 |
Brugia malayi | serine/threonine protein kinase 6 | 0.031 | 0.129 | 0.2744 |
Trichomonas vaginalis | AGC family protein kinase | 0.031 | 0.129 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0129 | 0.0487 | 0.1034 |
Schistosoma mansoni | protein kinase | 0.031 | 0.129 | 0.2746 |
Schistosoma mansoni | tyrosine kinase | 0.1077 | 0.4696 | 1 |
Echinococcus granulosus | aurora kinase A | 0.031 | 0.129 | 0.2744 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0326 | 0.1363 | 0.29 |
Brugia malayi | serine/threonine kinase 12 | 0.031 | 0.129 | 0.2744 |
Schistosoma mansoni | tyrosine kinase | 0.058 | 0.2487 | 0.5296 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.0698 | 0.1485 |
Echinococcus granulosus | epidermal growth factor receptor | 0.058 | 0.2487 | 0.5295 |
Schistosoma mansoni | vesicular amine transporter | 0.002 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0326 | 0.1363 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0072 | 0.0149 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.031 | 0.129 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.031 | 0.129 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0025 | 0.0024 | 0.0048 |
Schistosoma mansoni | tyrosine kinase | 0.0345 | 0.1448 | 0.3083 |
Brugia malayi | follicle stimulating hormone receptor | 0.0241 | 0.0985 | 0.2095 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.002 | 0.0002 | 0.0003 |
Echinococcus granulosus | geminin | 0.0176 | 0.0698 | 0.1482 |
Echinococcus multilocularis | insulin receptor | 0.0345 | 0.1448 | 0.308 |
Treponema pallidum | licC protein (licC) | 0.0417 | 0.1764 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0417 | 0.1764 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1077 | 0.4696 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0145 | 0.0305 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0129 | 0.0487 | 0.1034 |
Entamoeba histolytica | protein kinase, putative | 0.031 | 0.129 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.031 | 0.129 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0129 | 0.0487 | 0.1034 |
Echinococcus granulosus | neuroglian | 0.0025 | 0.0024 | 0.0048 |
Trypanosoma cruzi | aurora B kinase, putative | 0.031 | 0.129 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.031 | 0.129 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0345 | 0.1448 | 0.3083 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0345 | 0.1448 | 0.308 |
Trichomonas vaginalis | AGC family protein kinase | 0.031 | 0.129 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.