Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.1195 | 0.4091 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0361 | 0.1188 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.003 | 0.0038 | 0.0094 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0315 | 0.1031 | 0.252 |
Brugia malayi | Protein kinase domain containing protein | 0.0383 | 0.1266 | 0.3096 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1195 | 0.4091 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0383 | 0.1266 | 0.3096 |
Loa Loa (eye worm) | AUR protein kinase | 0.0361 | 0.1188 | 0.2904 |
Schistosoma mansoni | tyrosine kinase | 0.0634 | 0.2141 | 0.5233 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0038 | 0.0094 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0383 | 0.1266 | 0.3096 |
Echinococcus multilocularis | neuroglian | 0.0024 | 0.0017 | 0.0041 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.2894 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.0002 | 0.0005 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0504 | 0.1686 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1195 | 0.4091 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0504 | 0.1686 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0361 | 0.1188 | 0.2904 |
Echinococcus multilocularis | 0.0369 | 0.1219 | 0.2979 | |
Schistosoma mansoni | tyrosine kinase | 0.0634 | 0.2141 | 0.5233 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0643 | 0.217 | 0.5305 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0504 | 0.1686 | 0.4121 |
Echinococcus multilocularis | insulin receptor | 0.0383 | 0.1266 | 0.3096 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0504 | 0.1686 | 0.4121 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 0.1188 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0361 | 0.1188 | 0.2904 |
Echinococcus granulosus | neuroglian | 0.0024 | 0.0017 | 0.0041 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0361 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0022 | 0.0053 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0504 | 0.1686 | 0.4121 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0361 | 0.1188 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0315 | 0.1031 | 0.252 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.2894 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.2894 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.217 | 0.5305 |
Schistosoma mansoni | tyrosine kinase | 0.0634 | 0.2141 | 0.5233 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 0.1188 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0361 | 0.1188 | 0.2904 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0025 | 0.0022 | 0.0053 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0383 | 0.1266 | 0.3096 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0361 | 0.1188 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0504 | 0.1686 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0361 | 0.1188 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0504 | 0.1686 | 0.4121 |
Treponema pallidum | licC protein (licC) | 0.0531 | 0.178 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0531 | 0.178 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0361 | 0.1188 | 0.2904 |
Schistosoma mansoni | cell adhesion molecule | 0.0025 | 0.0022 | 0.0053 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1195 | 0.4091 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0038 | 0.0094 |
Loa Loa (eye worm) | AUR protein kinase | 0.0361 | 0.1188 | 0.2904 |
Trichomonas vaginalis | AGC family protein kinase | 0.0361 | 0.1188 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0504 | 0.1686 | 0.4121 |
Echinococcus multilocularis | roundabout 2 | 0.003 | 0.0038 | 0.0094 |
Echinococcus granulosus | aurora kinase A | 0.0361 | 0.1188 | 0.2904 |
Echinococcus granulosus | insulin receptor | 0.0383 | 0.1266 | 0.3096 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0504 | 0.1686 | 0.4121 |
Loa Loa (eye worm) | AUR protein kinase | 0.0361 | 0.1188 | 0.2904 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0361 | 0.1188 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0361 | 0.1188 | 0.2904 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0295 | 0.096 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0383 | 0.1266 | 0.3096 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0361 | 0.1188 | 0.2904 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.217 | 0.5305 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0361 | 0.1188 | 0.2904 |
Schistosoma mansoni | tyrosine kinase | 0.0383 | 0.1266 | 0.3096 |
Echinococcus granulosus | twitchin | 0.0029 | 0.0033 | 0.0082 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0361 | 0.1188 | 0.2904 |
Entamoeba histolytica | protein kinase, putative | 0.0361 | 0.1188 | 0.5 |
Giardia lamblia | Aurora kinase | 0.0361 | 0.1188 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0504 | 0.1686 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1195 | 0.4091 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0361 | 0.1188 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0361 | 0.1188 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0643 | 0.217 | 0.5305 |
Brugia malayi | P38 map kinase family protein 2 | 0.0504 | 0.1686 | 0.4121 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0504 | 0.1686 | 0.4121 |
Schistosoma mansoni | nephrin | 0.0024 | 0.0017 | 0.0041 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0643 | 0.217 | 0.5305 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.