Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0724 | 0.3041 | 0.5268 |
Echinococcus multilocularis | insulin receptor | 0.0432 | 0.1756 | 0.3016 |
Entamoeba histolytica | protein kinase, putative | 0.0351 | 0.1401 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0351 | 0.1401 | 0.2399 |
Schistosoma mansoni | tyrosine kinase | 0.0432 | 0.1756 | 0.3042 |
Giardia lamblia | Aurora kinase | 0.0351 | 0.1401 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1344 | 0.5773 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1344 | 0.5773 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.2304 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1344 | 0.5773 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.2304 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0432 | 0.1756 | 0.3016 |
Schistosoma mansoni | tyrosine kinase | 0.1344 | 0.5773 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.2304 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0047 | 0.0064 | 0.011 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0351 | 0.1401 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.1401 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0432 | 0.1756 | 0.3016 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0252 | 0.0964 | 0.1639 |
Schistosoma mansoni | tyrosine kinase | 0.0713 | 0.2993 | 0.5184 |
Echinococcus granulosus | neuroglian | 0.0047 | 0.0064 | 0.0074 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1344 | 0.5773 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0351 | 0.1401 | 0.2399 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0422 | 0.1715 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0351 | 0.1401 | 0.2399 |
Entamoeba histolytica | protein kinase , putative | 0.0351 | 0.1401 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0038 | 0.0021 | 0.0037 |
Treponema pallidum | licC protein (licC) | 0.0422 | 0.1715 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0351 | 0.1401 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0582 | 0.2417 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0351 | 0.1401 | 0.2399 |
Schistosoma mansoni | cell adhesion molecule | 0.005 | 0.0075 | 0.0131 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0038 | 0.0021 | 0.0037 |
Leishmania major | protein kinase, putative | 0.0351 | 0.1401 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0622 | 0.2596 | 0.4476 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0252 | 0.0964 | 0.1639 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0252 | 0.0964 | 0.1639 |
Loa Loa (eye worm) | AUR protein kinase | 0.0351 | 0.1401 | 0.2399 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0118 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0075 | 0.0094 |
Schistosoma mansoni | vesicular amine transporter | 0.0038 | 0.0021 | 0.0037 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0724 | 0.3041 | 0.5251 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0351 | 0.1401 | 0.2399 |
Schistosoma mansoni | protein kinase | 0.0351 | 0.1401 | 0.2427 |
Trypanosoma brucei | aurora B kinase | 0.0351 | 0.1401 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0351 | 0.1401 | 1 |
Echinococcus granulosus | twitchin | 0.0051 | 0.008 | 0.0103 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.005 | 0.0075 | 0.0094 |
Echinococcus granulosus | roundabout 2 | 0.006 | 0.0118 | 0.0168 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0252 | 0.0964 | 0.1639 |
Echinococcus granulosus | insulin receptor | 0.0432 | 0.1756 | 0.3016 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0724 | 0.3041 | 0.5251 |
Echinococcus multilocularis | neuroglian | 0.0047 | 0.0064 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.1401 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0432 | 0.1756 | 0.3016 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0118 | 0.0168 |
Echinococcus multilocularis | 0.0415 | 0.1682 | 0.2887 | |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0351 | 0.1401 | 0.5 |
Brugia malayi | P38 map kinase family protein 2 | 0.0252 | 0.0964 | 0.1639 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0252 | 0.0964 | 0.1639 |
Echinococcus multilocularis | aurora kinase A | 0.0351 | 0.1401 | 0.2399 |
Entamoeba histolytica | protein kinase, putative | 0.0351 | 0.1401 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0351 | 0.1401 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.006 | 0.0118 | 0.0168 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0724 | 0.3041 | 0.5251 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0351 | 0.1401 | 0.2399 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0252 | 0.0964 | 0.1639 |
Schistosoma mansoni | tyrosine kinase | 0.0713 | 0.2993 | 0.5184 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0351 | 0.1401 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.1401 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.1401 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0351 | 0.1401 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0252 | 0.0964 | 0.1639 |
Schistosoma mansoni | tyrosine kinase | 0.0713 | 0.2993 | 0.5184 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0432 | 0.1756 | 0.3016 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0351 | 0.1401 | 0.2427 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0622 | 0.2596 | 0.4476 |
Echinococcus granulosus | aurora kinase A | 0.0351 | 0.1401 | 0.2399 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0351 | 0.1401 | 0.2399 |
Schistosoma mansoni | tyrosine kinase | 0.0432 | 0.1756 | 0.3042 |
Schistosoma mansoni | tyrosine kinase | 0.0724 | 0.3041 | 0.5268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.