TDR Targets

Basic information

Technical information

TDR Targets ID: 821952
Name: N-[[5-(1,3-benzothiazol-2-yl)-2-methylphenyl] carbamothioyl]furan-2-carboxamide
MW: 393.482 | Formula: C20H15N3O2S2
H donors: 2 H acceptors: 2 LogP: 5.4 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: S=C(NC(=O)c1ccco1)Nc1cc(ccc1C)c1nc2c(s1)cccc2
InChi: 1S/C20H15N3O2S2/c1-12-8-9-13(19-21-14-5-2-3-7-17(14)27-19)11-15(12)22-20(26)23-18(24)16-6-4-10-25-16/h2-11H,1H3,(H2,22,23,24,26)
InChiKey: GIOMMWWUFMAIFD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[[5-(1,3-benzothiazol-2-yl)-2-methyl-phenyl]carbamothioyl]furan-2-carboxamide
N-[[[5-(1,3-benzothiazol-2-yl)-2-methylphenyl]amino]-thioxomethyl]-2-furancarboxamide
N-[[5-(1,3-benzothiazol-2-yl)-2-methyl-phenyl]thiocarbamoyl]-2-furamide
ZINC05050522
BIM-0007117.P001
CBMicro_007251
STK063867
Oprea1_121995

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0114	0.0783	0.5
Loa Loa (eye worm)	plexin A	0.074	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5
Echinococcus granulosus	transcription factor collier	0.0114	0.0783	0.0783
Schistosoma mansoni	tyrosine kinase	0.0088	0.0394	0.0474
Echinococcus multilocularis	insulin receptor	0.0088	0.0394	0.0319
Schistosoma mansoni	hypothetical protein	0.0114	0.0783	0.0941
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0124	0.0922	0.0922
Brugia malayi	Furin-like cysteine rich region family protein	0.02	0.2043	0.1717
Schistosoma mansoni	semaphorin 5-related	0.0261	0.2947	0.3545
Echinococcus granulosus	exocyst complex component 2	0.0114	0.0783	0.0783
Echinococcus granulosus	epidermal growth factor receptor	0.02	0.2043	0.2043
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0114	0.0783	0.5
Echinococcus granulosus	semaphorin 5B	0.0261	0.2947	0.2947
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0114	0.0783	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0124	0.0922	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2947	0.2947
Brugia malayi	Plexin repeat family protein	0.0625	0.8313	0.8243
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0114	0.0783	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0645	0.8604	0.8604
Echinococcus multilocularis	plexin a4	0.074	1	1
Echinococcus multilocularis	hypothetical protein	0.0261	0.2947	0.2892
Schistosoma mansoni	tyrosine kinase	0.0087	0.0383	0.0461
Brugia malayi	IPT/TIG domain containing protein	0.0114	0.0783	0.0405
Entamoeba histolytica	protein kinase domain containing protein	0.0151	0.1321	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2947	0.2947
Entamoeba histolytica	tyrosin kinase, putative	0.0151	0.1321	1
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0088	0.0394	0.0319
Schistosoma mansoni	tyrosine kinase	0.0124	0.0922	0.1109
Onchocerca volvulus	Tyrosine kinase homolog	0.0194	0.1953	0.0882
Schistosoma mansoni	tyrosine kinase	0.02	0.2043	0.2458
Onchocerca volvulus		0.0625	0.8313	1
Schistosoma mansoni	plexin	0.0625	0.8313	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2947	0.2947
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0114	0.0783	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.025	0.2781	0.2781
Schistosoma mansoni	hypothetical protein	0.0364	0.4461	0.5367
Schistosoma mansoni	tyrosine kinase	0.0088	0.0394	0.0474
Echinococcus granulosus	roundabout 2	0.0067	0.0077	0.0077
Schistosoma mansoni	hypothetical protein	0.0261	0.2947	0.3545
Echinococcus granulosus	insulin receptor	0.0088	0.0394	0.0394
Brugia malayi	Sema domain containing protein	0.0261	0.2947	0.2657
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2947	0.2947
Schistosoma mansoni	hypothetical protein	0.0114	0.0783	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2947	0.2947
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0783	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0364	0.4461	0.4461
Schistosoma mansoni	tyrosine kinase	0.0087	0.0383	0.0461
Brugia malayi	hypothetical protein	0.0261	0.2947	0.2657
Onchocerca volvulus		0.0261	0.2947	0.2307
Schistosoma mansoni	plexin	0.0364	0.4461	0.5367
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0783	0.0783
Brugia malayi	Immunoglobulin I-set domain containing protein	0.025	0.2781	0.2485
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2947	0.2947
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0077	0.0077
Brugia malayi	Probable exocyst complex component Sec5	0.0114	0.0783	0.0405
Echinococcus multilocularis	transcription factor collier	0.0114	0.0783	0.0711
Schistosoma mansoni	tyrosine kinase	0.0087	0.0383	0.0461
Echinococcus granulosus	plexin a4	0.074	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5
Loa Loa (eye worm)	sema domain-containing protein	0.0261	0.2947	0.2947
Loa Loa (eye worm)	TK/EGFR protein kinase	0.02	0.2043	0.2043
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5
Schistosoma mansoni	fibrocystin l	0.0114	0.0783	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0783	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0783	0.0783
Echinococcus multilocularis	exocyst complex component 2	0.0114	0.0783	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0625	0.8313	0.8313
Schistosoma mansoni	tyrosine kinase	0.0124	0.0922	0.1109
Loa Loa (eye worm)	TK/INSR protein kinase	0.0088	0.0394	0.0394
Echinococcus granulosus	semaphorin 1A	0.0261	0.2947	0.2947
Echinococcus multilocularis	epidermal growth factor receptor	0.02	0.2043	0.1981
Brugia malayi	DNA-binding protein LAG-1	0.0114	0.0783	0.0405
Echinococcus granulosus	epidermal growth factor receptor	0.0124	0.0922	0.0922
Brugia malayi	Sema domain containing protein	0.0261	0.2947	0.2657
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0088	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0077	0.0077
Loa Loa (eye worm)	sema domain-containing protein	0.0261	0.2947	0.2947
Brugia malayi	hypothetical protein	0.0261	0.2947	0.2657
Echinococcus multilocularis	semaphorin 5B	0.0261	0.2947	0.2892
Schistosoma mansoni	hypothetical protein	0.0261	0.2947	0.3545
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0783	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 821952