Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0055 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0055 | 0.0055 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.3903 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1876 | 0.4732 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.3903 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0055 | 0.0055 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1876 | 0.4732 | 0.4732 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0055 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1876 | 0.4732 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1876 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.3903 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.3903 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1876 | 0.4732 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0959 | 0.2349 | 0.2349 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0055 | 0.0055 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0055 | 0.0055 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0055 | 0.0055 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.3903 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0055 | 0.0055 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0055 | 0.0055 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0055 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0055 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0055 | 0.0055 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2079 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.