Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0303 | 0.0515 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.3595 | 0.7916 | 0.7924 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0303 | 0.0515 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0246 | 0.0126 |
Giardia lamblia | Kinesin-5 | 0.0467 | 0.0883 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0467 | 0.0883 | 1 |
Onchocerca volvulus | 0.0184 | 0.0246 | 0.0126 | |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0246 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.1208 | 0.5176 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0602 | 0.1186 | 0.0992 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0173 | 0.0223 | 0.1046 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0173 | 0.0223 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0467 | 0.0883 | 0.4152 |
Echinococcus multilocularis | conserved hypothetical protein | 0.4491 | 0.9932 | 1 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0303 | 0.0515 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.102 | 0.2127 | 1 |
Echinococcus granulosus | translocator protein | 0.0184 | 0.0246 | 0.0025 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0602 | 0.1186 | 0.0985 |
Onchocerca volvulus | 0.0184 | 0.0246 | 0.0126 | |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.1208 | 0.5176 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0303 | 0.0515 | 0.0299 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0303 | 0.0515 | 0.5 |
Onchocerca volvulus | 0.0184 | 0.0246 | 0.0126 | |
Loa Loa (eye worm) | hypothetical protein | 0.102 | 0.2127 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0223 | 0.1046 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.102 | 0.2127 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0223 | 0.1046 |
Schistosoma mansoni | kinesin eg-5 | 0.0467 | 0.0883 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0257 | 0.018 |
Brugia malayi | TspO/MBR family protein | 0.0184 | 0.0246 | 0.1159 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.102 | 0.2127 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.102 | 0.2127 | 0.2867 |
Onchocerca volvulus | 0.102 | 0.2127 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0175 | 0.0227 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.102 | 0.2127 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.3595 | 0.7916 | 0.7869 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.102 | 0.2127 | 0.2867 |
Schistosoma mansoni | hypothetical protein | 0.3128 | 0.6866 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0246 | 0.0126 |
Onchocerca volvulus | 0.0184 | 0.0246 | 0.0126 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0223 | 0.1046 |
Loa Loa (eye worm) | TTK protein kinase | 0.0303 | 0.0515 | 0.1534 |
Brugia malayi | Protein kinase domain containing protein | 0.0303 | 0.0515 | 0.242 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.102 | 0.2127 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.102 | 0.2127 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0467 | 0.0883 | 0.3468 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0246 | 0.0126 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0184 | 0.0246 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0303 | 0.0515 | 0.0301 |
Echinococcus multilocularis | serotonin transporter | 0.102 | 0.2127 | 0.1962 |
Entamoeba histolytica | kinesin, putative | 0.0467 | 0.0883 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.102 | 0.2127 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0612 | 0.1208 | 0.568 |
Brugia malayi | hypothetical protein | 0.0173 | 0.0223 | 0.1046 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0467 | 0.0883 | 1 |
Echinococcus granulosus | serotonin transporter | 0.102 | 0.2127 | 0.1948 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0184 | 0.0246 | 0.0036 |
Plasmodium vivax | kinesin-5 | 0.0467 | 0.0883 | 1 |
Echinococcus multilocularis | translocator protein | 0.0184 | 0.0246 | 0.0025 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0612 | 0.1208 | 0.1484 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0191 | 0.0263 | 0.0214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.