TDR Targets

Basic information

Technical information

TDR Targets ID: 826647
Name: 2-[2-(methoxymethyl)benzimidazol-1-yl]-N-phen yl-N-propan-2-ylacetamide
MW: 337.416 | Formula: C20H23N3O2
H donors: 0 H acceptors: 2 LogP: 3.11 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCc1nc2c(n1CC(=O)N(c1ccccc1)C(C)C)cccc2
InChi: 1S/C20H23N3O2/c1-15(2)23(16-9-5-4-6-10-16)20(24)13-22-18-12-8-7-11-17(18)21-19(22)14-25-3/h4-12,15H,13-14H2,1-3H3
InChiKey: YYBRFFMBJQPRRU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-isopropyl-2-[2-(methoxymethyl)benzimidazol-1-yl]-N-phenyl-acetamide
N-isopropyl-2-[2-(methoxymethyl)-1-benzimidazolyl]-N-phenylacetamide
2-[2-(methoxymethyl)benzimidazol-1-yl]-N-phenyl-N-propan-2-yl-ethanamide
T5443800
ZINC00572703
IFLab1_006151

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0399	0.5531	0.5057
Entamoeba histolytica	cysteine proteinase, putative	0.0199	0.096	0.3182
Loa Loa (eye worm)	cathepsin B	0.023	0.1671	0.0787
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0595	1	1
Plasmodium vivax	vivapain-2	0.0289	0.3018	1
Giardia lamblia	Cathepsin B precursor	0.023	0.1671	0.5
Loa Loa (eye worm)	hypothetical protein	0.0595	1	1
Echinococcus multilocularis	cathepsin b	0.0595	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Echinococcus multilocularis	cathepsin b	0.0595	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0595	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Onchocerca volvulus		0.0289	0.3018	0.4502
Leishmania major	cysteine peptidase A (CPA)	0.0289	0.3018	0.5262
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Loa Loa (eye worm)	fibroinase	0.0289	0.3018	0.2276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Toxoplasma gondii	cathepsin CPL	0.0289	0.3018	0.3489
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0289	0.3018	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0595	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0289	0.3018	0.3018
Echinococcus multilocularis	cathepsin L cysteine protease	0.0289	0.3018	0.3018
Trypanosoma cruzi	cysteine peptidase, putative	0.0289	0.3018	0.3018
Brugia malayi	prolyl oligopeptidase family protein	0.0399	0.5531	0.5531
Brugia malayi	Cathepsin L-like precursor	0.0199	0.096	0.096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0595	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0289	0.3018	0.3018
Trypanosoma cruzi	cysteine peptidase, putative	0.0289	0.3018	0.3018
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0199	0.096	0.096
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0399	0.5531	0.5531
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.023	0.1671	0.1671
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.1184	0.1184
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Onchocerca volvulus		0.0289	0.3018	0.4502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Onchocerca volvulus	Cathepsin F homolog	0.0289	0.3018	0.4502
Giardia lamblia	Cathepsin B precursor	0.023	0.1671	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0199	0.096	0.096
Brugia malayi	cathepsin L-like precursor	0.0199	0.096	0.096
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.1184	0.0247
Echinococcus granulosus	cathepsin b	0.0595	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0346	0.4303	1
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0167	0.0227	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0399	0.5531	1
Loa Loa (eye worm)	ctsf protein	0.0289	0.3018	0.2276
Echinococcus granulosus	cathepsin b	0.0595	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Echinococcus multilocularis	cysteine protease	0.0289	0.3018	0.3018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0289	0.3018	0.3018
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0399	0.5531	0.5531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Brugia malayi	Cathepsin L-like precursor	0.0289	0.3018	0.3018
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Echinococcus multilocularis	cysteine protease	0.0289	0.3018	0.3018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.023	0.1671	0.1671
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Plasmodium vivax	vivapain-2	0.0289	0.3018	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.023	0.1671	0.3022
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.1184	0.1184
Trypanosoma cruzi	cruzipain precursor, putative	0.0289	0.3018	0.3018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.023	0.1671	0.5538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Onchocerca volvulus		0.0289	0.3018	0.4502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Trypanosoma cruzi	prolyl endopeptidase	0.0399	0.5531	0.5531
Brugia malayi	Cathepsin L-like precursor	0.0199	0.096	0.096
Loa Loa (eye worm)	cysteine protease	0.0289	0.3018	0.2276
Trypanosoma cruzi	oligopeptidase b	0.0167	0.0227	0.0227
Onchocerca volvulus	Cathepsin L homolog	0.0289	0.3018	0.4502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Echinococcus granulosus	cathepsin l1	0.0199	0.096	0.096
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0199	0.096	0.3182
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.1184	0.0489
Entamoeba histolytica	cysteine proteinase, putative	0.0289	0.3018	1
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Brugia malayi	Cathepsin L-like precursor	0.0289	0.3018	0.3018
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0289	0.3018	1
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0167	0.0227	0.041
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0167	0.0227	0.041
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0289	0.3018	0.2276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Onchocerca volvulus		0.0289	0.3018	0.4502
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0289	0.3018	0.2276
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0289	0.3018	0.3018
Echinococcus granulosus	cathepsin l1	0.0289	0.3018	0.3018
Brugia malayi	Cathepsin L-like precursor	0.0289	0.3018	0.3018
Schistosoma mansoni	cathepsin F (C01 family)	0.0199	0.096	0.096
Schistosoma mansoni	cathepsin F (C01 family)	0.0289	0.3018	0.3018
Onchocerca volvulus		0.0289	0.3018	0.4502
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0167	0.0227	0.0227
Trypanosoma brucei	prolyl endopeptidase	0.0399	0.5531	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0289	0.3018	0.3018
Trypanosoma cruzi	cysteine peptidase, putative	0.0289	0.3018	0.3018
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0595	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0289	0.3018	0.3018
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0399	0.5531	1
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.1184	0.1184
Brugia malayi	Papain family cysteine protease containing protein	0.0289	0.3018	0.3018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Onchocerca volvulus	Cathepsin L homolog	0.0289	0.3018	0.4502
Trypanosoma cruzi	cysteine peptidase, putative	0.0289	0.3018	0.3018
Trypanosoma cruzi	oligopeptidase b	0.0167	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0289	0.3018	1
Giardia lamblia	Cathepsin B precursor	0.023	0.1671	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1
Trypanosoma brucei	oligopeptidase b	0.0167	0.0227	0.041
Entamoeba histolytica	cysteine protease, putative	0.0289	0.3018	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0199	0.096	0.3182
Echinococcus granulosus	prolyl endopeptidase	0.0399	0.5531	0.5531
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0289	0.3018	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.023	0.1671	0.2723
Brugia malayi	Cathepsin L-like precursor	0.0289	0.3018	0.3018
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0167	0.0227	0.0227
Onchocerca volvulus		0.0289	0.3018	0.4502
Onchocerca volvulus		0.0289	0.3018	0.4502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0167	0.0227	0.5
Loa Loa (eye worm)	hypothetical protein	0.0289	0.3018	0.2276
Brugia malayi	Cathepsin L-like precursor	0.0289	0.3018	0.3018
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Echinococcus multilocularis	prolyl endopeptidase	0.0399	0.5531	0.5531
Leishmania major	cathepsin L-like protease	0.0289	0.3018	0.5262
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Toxoplasma gondii	prolyl endopeptidase	0.0399	0.5531	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0289	0.3018	1
Brugia malayi	Cathepsin L-like precursor	0.0289	0.3018	0.3018
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.1184	0.1184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0289	0.3018	0.5456
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0289	0.3018	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 826647