Detailed information for compound 826979

Basic information

Technical information
  • TDR Targets ID: 826979
  • Name: 5,7-dimethyl-2-(4-methylphenyl)-[1,2,4]triazo lo[1,5-a]pyrimidine
  • MW: 238.288 | Formula: C14H14N4
  • H donors: 0 H acceptors: 3 LogP: 2.92 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1nc2n(n1)c(C)cc(n2)C
  • InChi: 1S/C14H14N4/c1-9-4-6-12(7-5-9)13-16-14-15-10(2)8-11(3)18(14)17-13/h4-8H,1-3H3
  • InChiKey: DDMCBXQCCISRAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00529169

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Histone deacetylase 10 homolog 0.031 0.5457 0.9341
Schistosoma mansoni hypothetical protein 0.0553 1 1
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.002 0.0053 0.0053
Echinococcus granulosus tar DNA binding protein 0.0068 0.0948 0.0948
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.002 0.0053 0.0074
Echinococcus granulosus histone deacetylase 7 0.0403 0.7198 0.7198
Giardia lamblia Histone deacetylase 0.031 0.5457 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0195 0.0271
Schistosoma mansoni histone deacetylase hda2 0.0424 0.7579 0.7579
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.031 0.5457 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0948 0.1316
Echinococcus multilocularis histone deacetylase 6 0.0424 0.7579 0.7579
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.2152 0.2989
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0707 0.0983
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.031 0.5457 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.002 0.0053 0.0053
Leishmania major hypothetical protein, conserved 0.0028 0.0195 0.0271
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0053 0.0074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.0053 0.0074
Brugia malayi hypothetical protein 0.0028 0.0195 0.0271
Toxoplasma gondii histone deacetylase HDAC5 0.031 0.5457 0.7582
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.002 0.0053 0.0074
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.002 0.0053 0.0074
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0053 0.0074
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.002 0.0053 0.0074
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0053 0.0074
Trichomonas vaginalis histone deacetylase, putative 0.031 0.5457 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0195 0.0271
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.002 0.0053 0.0053
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.002 0.0053 0.0053
Echinococcus granulosus histone deacetylase 8 0.031 0.5457 0.5457
Trichomonas vaginalis histone deacetylase, putative 0.031 0.5457 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0948 0.0948
Echinococcus granulosus histone deacetylase 1 0.031 0.5457 0.5457
Echinococcus multilocularis histone deacetylase 8 0.031 0.5457 0.5457
Plasmodium falciparum histone deacetylase, putative 0.0403 0.7198 1
Plasmodium vivax histone deacetylase 1, putative 0.031 0.5457 0.7582
Leishmania major histone deacetylase, putative 0.031 0.5457 0.7582
Brugia malayi Histone deacetylase 1 0.031 0.5457 0.7582
Trypanosoma brucei histone deacetylase, putative 0.0403 0.7198 1
Schistosoma mansoni brca1-associated protein (brap2) 0.002 0.0053 0.0053
Trypanosoma cruzi histone deacetylase, putative 0.0403 0.7198 1
Echinococcus multilocularis histone deacetylase 0.0403 0.7198 0.7198
Trypanosoma brucei histone deacetylase 1 0.031 0.5457 0.7582
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0195 0.0271
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.038 0.0528
Brugia malayi BRCA1-associated protein 2 containing protein 0.002 0.0053 0.0074
Schistosoma mansoni histone deacetylase 1 2 3 0.031 0.5457 0.5457
Loa Loa (eye worm) hypothetical protein 0.031 0.5457 0.7582
Plasmodium vivax histone deacetylase, putative 0.031 0.5457 0.7582
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0195 0.0271
Loa Loa (eye worm) histone deacetylase 0.0403 0.7198 1
Echinococcus granulosus histone deacetylase 6 0.0403 0.7198 0.7198
Brugia malayi Histone deacetylase family protein 0.0403 0.7198 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0948 0.0948
Toxoplasma gondii UBA/TS-N domain-containing protein 0.002 0.0053 0.0074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.0053 0.0074
Plasmodium falciparum histone deacetylase 1 0.031 0.5457 0.7582
Schistosoma mansoni hypothetical protein 0.0038 0.038 0.038
Brugia malayi hypothetical protein 0.033 0.5839 0.8112
Trypanosoma cruzi histone deacetylase, putative 0.0403 0.7198 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.002 0.0053 0.0053
Loa Loa (eye worm) histone deacetylase 1 0.031 0.5457 0.7582
Loa Loa (eye worm) histone deacetylase 7A 0.0403 0.7198 1
Echinococcus granulosus histone deacetylase 6 0.0403 0.7198 0.7198
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0053 0.0074
Schistosoma mansoni histone deacetylase 0.031 0.5457 0.5457
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.002 0.0053 0.0074
Brugia malayi Histone deacetylase family protein 0.0403 0.7198 1
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.002 0.0053 0.0074
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0948 0.1316
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0195 0.0271
Loa Loa (eye worm) hypothetical protein 0.031 0.5457 0.7582
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0707 0.0983
Loa Loa (eye worm) hypothetical protein 0.0093 0.1412 0.1962
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0053 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0707 0.0983
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0195 0.0271
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.002 0.0053 0.0074
Echinococcus granulosus histone deacetylase 3 0.031 0.5457 0.5457
Leishmania major histone deacetylase, putative 0.0403 0.7198 1
Echinococcus granulosus histone deacetylase 0.0403 0.7198 0.7198
Trypanosoma cruzi histone deacetylase, putative 0.031 0.5457 0.7582
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0195 0.0271
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0948 0.0948
Echinococcus multilocularis histone deacetylase 6 0.0403 0.7198 0.7198
Brugia malayi histone deacetylase 3 (HD3) 0.031 0.5457 0.7582
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.002 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.0707 0.0983
Brugia malayi histone deacetylase 1 (HD1) 0.031 0.5457 0.7582
Schistosoma mansoni histone deacetylase 4 5 0.0403 0.7198 0.7198
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0948 0.0948
Loa Loa (eye worm) histone deacetylase 3 0.031 0.5457 0.7582
Trichomonas vaginalis histone deacetylase, putative 0.031 0.5457 1
Entamoeba histolytica histone deacetylase, putative 0.031 0.5457 1
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.002 0.0053 0.0074
Toxoplasma gondii histone deacetylase HDAC1 0.0403 0.7198 1
Trichomonas vaginalis histone deacetylase, putative 0.031 0.5457 1
Toxoplasma gondii histone deacetylase HDAC3 0.031 0.5457 0.7582
Leishmania major histone deacetylase, putative 0.031 0.5457 0.7582
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0948 0.0948
Trypanosoma cruzi histone deacetylase 1, putative 0.031 0.5457 0.7582
Plasmodium vivax histone deacetylase 2, putative 0.0403 0.7198 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0195 0.0271
Brugia malayi TAR-binding protein 0.0068 0.0948 0.1316
Trichomonas vaginalis histone deacetylase, putative 0.031 0.5457 1
Trypanosoma cruzi histone deacetylase, putative 0.031 0.5457 0.7582
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0948 0.0948
Leishmania major histone deacetylase, putative 0.0403 0.7198 1
Leishmania major hypothetical protein, conserved 0.002 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.033 0.5839 0.8112
Trichomonas vaginalis histone deacetylase, putative 0.031 0.5457 1
Toxoplasma gondii histone deacetylase HDAC2 0.031 0.5457 0.7582
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.0053 0.0074
Schistosoma mansoni histone deacetylase 0.031 0.5457 0.5457
Trypanosoma cruzi histone deacetylase, putative 0.0403 0.7198 1
Schistosoma mansoni brca1-associated protein (brap2) 0.002 0.0053 0.0053
Echinococcus multilocularis BRCA1 associated protein 0.002 0.0053 0.0053
Loa Loa (eye worm) histone deacetylase 11 0.031 0.5457 0.7582
Echinococcus granulosus histone deacetylase 6 0.0424 0.7579 0.7579
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.002 0.0053 0.0053
Brugia malayi histone deacetylase 11 0.031 0.5457 0.7582
Onchocerca volvulus 0.033 0.5839 1
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.002 0.0053 0.0074
Schistosoma mansoni hypothetical protein 0.0553 1 1
Echinococcus multilocularis histone deacetylase 7 0.0403 0.7198 0.7198
Loa Loa (eye worm) RNA binding protein 0.0068 0.0948 0.1316
Trypanosoma brucei histone deacetylase 4 0.0403 0.7198 1
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.002 0.0053 0.0074
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.2152 0.2989
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.002 0.0053 0.0074
Toxoplasma gondii histone deacetylase HDAC4 0.031 0.5457 0.7582
Echinococcus granulosus BRCA1 associated protein 0.002 0.0053 0.0053
Brugia malayi RNA binding protein 0.0068 0.0948 0.1316
Trypanosoma brucei histone deacetylase 2 0.031 0.5457 0.7582
Trypanosoma cruzi histone deacetylase 1, putative 0.031 0.5457 0.7582
Brugia malayi MH2 domain containing protein 0.0133 0.2152 0.2989
Plasmodium falciparum histone deacetylase 2 0.0403 0.7198 1
Schistosoma mansoni histone deacetylase 4 5 0.0403 0.7198 0.7198
Echinococcus multilocularis histone deacetylase 3 0.031 0.5457 0.5457
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.002 0.0053 0.0074
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.002 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0114 0.1793 0.2492
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.002 0.0053 0.0074
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.002 0.0053 0.0074
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.002 0.0053 0.0053
Echinococcus multilocularis histone deacetylase 6 0.0403 0.7198 0.7198
Trypanosoma brucei histone deacetylase 3 0.0403 0.7198 1
Plasmodium vivax histone deacetylase, putative 0.0403 0.7198 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.031 0.5457 1
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.002 0.0053 0.0074
Echinococcus multilocularis geminin 0.0553 1 1
Echinococcus multilocularis histone deacetylase 1 0.031 0.5457 0.5457
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.002 0.0053 0.0074
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.002 0.0053 0.0053
Schistosoma mansoni histone deacetylase hda2 0.031 0.5457 0.5457
Loa Loa (eye worm) hypothetical protein 0.0038 0.038 0.0528
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0948 0.1316

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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