Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.1804 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0772 | 0.1804 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2487 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0772 | 0.1804 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.2487 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2487 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.2487 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0772 | 0.1804 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.2487 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.2487 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0772 | 0.1804 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.2487 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.