Detailed information for compound 829691

Basic information

Technical information
  • TDR Targets ID: 829691
  • Name: 3-(4-methoxyphenyl)-5,9-dimethylfuro[3,2-g]ch romen-7-one
  • MW: 320.339 | Formula: C20H16O4
  • H donors: 0 H acceptors: 1 LogP: 4.19 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1coc2c1cc1c(C)cc(=O)oc1c2C
  • InChi: 1S/C20H16O4/c1-11-8-18(21)24-20-12(2)19-16(9-15(11)20)17(10-23-19)13-4-6-14(22-3)7-5-13/h4-10H,1-3H3
  • InChiKey: KHZVTSFDVDNFMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methoxyphenyl)-5,9-dimethyl-furo[3,2-g]chromen-7-one
  • 3-(4-methoxyphenyl)-5,9-dimethyl-7-furo[3,2-g]chromenone
  • STOCK1N-37223
  • ZINC00489105

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0171 0.5
Brugia malayi O-methyltransferase family protein 0.0059 0.0878 0.3109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0628 0.2739
Schistosoma mansoni hypothetical protein 0.0016 0.01 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0459 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0701 0.2435
Trypanosoma brucei RNA helicase, putative 0.0105 0.1695 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0459 1
Schistosoma mansoni DNA helicase recq5 0.002 0.0171 0.0747
Schistosoma mansoni hypothetical protein 0.0016 0.01 0.0436
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0059 0.1291
Onchocerca volvulus 0.0059 0.0878 0.5754
Loa Loa (eye worm) hypothetical protein 0.0016 0.01 0.0154
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0459 1
Schistosoma mansoni o-methyltransferase 0.0059 0.0878 0.383
Loa Loa (eye worm) hypothetical protein 0.0034 0.0423 0.1379
Onchocerca volvulus 0.0093 0.1483 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.01 0.0154
Loa Loa (eye worm) hypothetical protein 0.0049 0.0701 0.2435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0701 0.2435
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.00000000014403 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.01 0.0436
Brugia malayi Latrophilin receptor protein 2 0.0016 0.01 0.0154
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0171 0.0275
Schistosoma mansoni o-methyltransferase 0.0059 0.0878 0.383
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0171 0.0275
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0171 0.2801
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0459 0.1518
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0628 0.216
Brugia malayi O-methyltransferase 0.0059 0.0878 0.3109
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0171 0.373
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0459 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.2294 1
Echinococcus granulosus bloom syndrome protein 0.002 0.0171 0.0275
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0459 0.1385
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0171 0.0425
Loa Loa (eye worm) hypothetical protein 0.0059 0.0878 0.3109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0628 0.2037
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.0512 0.8944 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.0171 0.0275
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0171 0.2801
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0459 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0171 0.0747
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0423 0.1379
Schistosoma mansoni alpha glucosidase 0.0036 0.0459 0.2002
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0459 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0459 1
Schistosoma mansoni o-methyltransferase 0.0059 0.0878 0.383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0628 0.2739
Loa Loa (eye worm) RecQ helicase 0.002 0.0171 0.0425
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.2693 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.2294 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0459 0.1385
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.2693 1
Onchocerca volvulus 0.0059 0.0878 0.5754
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0171 0.5
Brugia malayi O-methyltransferase family protein 0.0059 0.0878 0.3109
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0171 0.2801
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0459 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.01 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0459 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0701 0.2435
Brugia malayi O-methyltransferase family protein 0.0059 0.0878 0.3109
Loa Loa (eye worm) hypothetical protein 0.002 0.0171 0.0425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0628 0.2037
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0171 0.2801
Schistosoma mansoni hypothetical protein 0.0016 0.01 0.0436
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0459 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0171 0.0425
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2693 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0171 0.5
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0171 0.0425
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0459 1
Schistosoma mansoni hypothetical protein 0.0034 0.0423 0.1842
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0628 0.2037
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0171 0.0275
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0171 0.0684
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0171 0.373
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0171 0.2801
Schistosoma mansoni hypothetical protein 0.0105 0.1695 0.7392
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0628 0.216
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0459 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0171 0.0275
Schistosoma mansoni o-methyltransferase 0.0059 0.0878 0.383
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0059 0.0878 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2693 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0628 0.2037
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.2693 1
Loa Loa (eye worm) O-methyltransferase 0.0059 0.0878 0.3109
Trypanosoma brucei glucosidase, putative 0.0036 0.0459 0.2444
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0459 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0628 0.2739
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0459 1
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0059 0.0878 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0459 1
Entamoeba histolytica recQ family helicase, putative 0.002 0.0171 0.373
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0171 0.0425
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0459 0.1518

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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