Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | O-methyltransferase family protein | 0.0059 | 0.0878 | 0.3109 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.0171 | 0.0747 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.01 | 0.0436 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.1695 | 0.7392 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0701 | 0.2435 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.0171 | 0.0275 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0459 | 1 |
Brugia malayi | O-methyltransferase family protein | 0.0059 | 0.0878 | 0.3109 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.01 | 0.0154 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.0171 | 0.0275 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0459 | 0.1518 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0459 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.0171 | 0.0275 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0459 | 0.2002 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.0171 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0628 | 0.2739 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.01 | 0.0436 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0459 | 1 |
Brugia malayi | O-methyltransferase | 0.0059 | 0.0878 | 0.3109 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0459 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.2294 | 1 |
Onchocerca volvulus | 0.0059 | 0.0878 | 0.5754 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0878 | 0.3109 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0701 | 0.2435 |
Loa Loa (eye worm) | O-methyltransferase | 0.0059 | 0.0878 | 0.3109 |
Trypanosoma brucei | RNA helicase, putative | 0.0105 | 0.1695 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0459 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0171 | 0.2801 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.2693 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0459 | 0.2444 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.2294 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.2693 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0423 | 0.1379 |
Onchocerca volvulus | 0.0059 | 0.0878 | 0.5754 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.01 | 0.0154 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0628 | 0.2739 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.2693 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.0171 | 0.373 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0459 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0459 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.0171 | 0.0275 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0171 | 0.373 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0628 | 0.216 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.0171 | 0.0425 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0628 | 0.2037 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0459 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0628 | 0.2739 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.2693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.01 | 0.0436 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.002 | 0.0171 | 0.2801 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0013 | 0.0059 | 0.1291 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.0171 | 0.0425 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0459 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0459 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0171 | 0.0684 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0628 | 0.216 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.0171 | 0.2801 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0423 | 0.1379 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0628 | 0.2037 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.0171 | 0.0747 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.01 | 0.0436 |
Schistosoma mansoni | o-methyltransferase | 0.0059 | 0.0878 | 0.383 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.0171 | 0.2801 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0701 | 0.2435 |
Brugia malayi | O-methyltransferase family protein | 0.0059 | 0.0878 | 0.3109 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.01 | 0.0154 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.00000000014403 | 0.5 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.0171 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0628 | 0.2037 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.0171 | 0.0275 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0423 | 0.1842 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0171 | 0.0425 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.01 | 0.0154 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0459 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0459 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0171 | 0.0425 |
Schistosoma mansoni | o-methyltransferase | 0.0059 | 0.0878 | 0.383 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.2693 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0171 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0171 | 0.0425 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0171 | 0.373 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0459 | 0.1385 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0459 | 1 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0059 | 0.0878 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0459 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0701 | 0.2435 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.0171 | 0.0275 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0059 | 0.0878 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0459 | 1 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0512 | 0.8944 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0628 | 0.2037 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0459 | 1 |
Onchocerca volvulus | 0.0093 | 0.1483 | 1 | |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0171 | 0.2801 |
Schistosoma mansoni | o-methyltransferase | 0.0059 | 0.0878 | 0.383 |
Schistosoma mansoni | o-methyltransferase | 0.0059 | 0.0878 | 0.383 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0459 | 0.1518 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.0171 | 0.0425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.