Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Rattus norvegicus | Purine-nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0308 | 1 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0308 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0308 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0308 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0308 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0308 | 1 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0308 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0308 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0308 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20.2 nM | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM. | ChEMBL. | 10395483 |
IC50 (binding) | = 20.2 nM | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM. | ChEMBL. | 10395483 |
IC50 (binding) | = 29 nM | Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) | ChEMBL. | 8057293 |
IC50 (binding) | = 29 nM | Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) | ChEMBL. | 8057293 |
IC50 (binding) | = 0.029 uM | In vitro inhibition of purine nucleoside phosphorylase from calf spleen in 1 mM phosphate | ChEMBL. | 8515423 |
IC50 (binding) | = 0.029 uM | In vitro inhibition of purine nucleoside phosphorylase from calf spleen in 1 mM phosphate | ChEMBL. | 8515423 |
IC50 (binding) | = 1.8 uM | Inhibition of purine nucleoside phosphorylase from calf spleen in 50 mM phosphate | ChEMBL. | 8515423 |
IC50 (binding) | = 1.8 uM | Inhibition of purine nucleoside phosphorylase from calf spleen in 50 mM phosphate | ChEMBL. | 8515423 |
Ki (binding) | = 6.2 nM | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as substrate. | ChEMBL. | 10395483 |
Ki (binding) | = 6.2 nM | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as substrate. | ChEMBL. | 10395483 |
Ki (binding) | = 9.1 nM | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM. | ChEMBL. | 10395483 |
Ki (binding) | = 9.1 nM | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM. | ChEMBL. | 10395483 |
Ratio (binding) | = 1.97 | Ratio of Ki ino and Kimesg against purine nucleoside phosphorylase (PNP) | ChEMBL. | 10395483 |
Ratio (binding) | = 2.2 | Ratio of IC50 ino and Ki ino against purine nucleoside phosphorylase (PNP) | ChEMBL. | 10395483 |
Ratio (binding) | = 29 | Ratio of IC50 values for guanine and related hypoxanthines in PNP inhibition assay | ChEMBL. | 8057293 |
Ratio (binding) | = 62 | Ratio of IC50 between 50 mM phosphate and 1 mM phosphate assays | ChEMBL. | 8515423 |
Ratio (binding) | = 1.97 | Ratio of Ki ino and Kimesg against purine nucleoside phosphorylase (PNP) | ChEMBL. | 10395483 |
Ratio (binding) | = 2.2 | Ratio of IC50 ino and Ki ino against purine nucleoside phosphorylase (PNP) | ChEMBL. | 10395483 |
Ratio (binding) | = 29 | Ratio of IC50 values for guanine and related hypoxanthines in PNP inhibition assay | ChEMBL. | 8057293 |
Ratio (binding) | = 62 | Ratio of IC50 between 50 mM phosphate and 1 mM phosphate assays | ChEMBL. | 8515423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.