Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | 0.0101 | 0.0855 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0339 | 1 | 0.5 |
Brugia malayi | ShTK domain containing protein | 0.0283 | 0.7848 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0283 | 0.7848 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0283 | 0.7848 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0283 | 0.7848 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.1508 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0283 | 0.7848 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0339 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0339 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0339 | 1 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0283 | 0.7848 | 1 |
Onchocerca volvulus | 0.0283 | 0.7848 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.7848 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0339 | 1 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0283 | 0.7848 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0339 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.1508 | 0.1921 |
Onchocerca volvulus | 0.0283 | 0.7848 | 1 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0283 | 0.7848 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0138 | 0.0176 |
Onchocerca volvulus | 0.0283 | 0.7848 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0283 | 0.7848 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.1508 | 1 |
Onchocerca volvulus | 0.0283 | 0.7848 | 1 | |
Loa Loa (eye worm) | tyrosinase 1 | 0.0283 | 0.7848 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0339 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0855 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.7848 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0283 | 0.7848 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.