Detailed information for compound 831213

Basic information

Technical information
  • TDR Targets ID: 831213
  • Name: 2,4-dimethyl-N-(5-methyl-1,3,4-thiadiazol-2-y l)-1,3-thiazole-5-carboxamide
  • MW: 254.332 | Formula: C9H10N4OS2
  • H donors: 1 H acceptors: 4 LogP: 2.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nnc(s1)NC(=O)c1sc(nc1C)C
  • InChi: 1S/C9H10N4OS2/c1-4-7(15-5(2)10-4)8(14)11-9-13-12-6(3)16-9/h1-3H3,(H,11,13,14)
  • InChiKey: WOTGPKPXSJJCPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,4-dimethyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)thiazole-5-carboxamide
  • 2,4-dimethyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-thiazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Plasmodium vivax heat shock protein, putative 0.0027 0.014 0.0262
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.3552 0.664
Loa Loa (eye worm) heat shock protein 75 0.0027 0.014 0.018
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0099 1 1
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Echinococcus granulosus caspase 0.0099 1 1
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.5349 1
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.5349 1
Brugia malayi heat shock protein 90 0.0065 0.5349 0.6888
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trichomonas vaginalis heat shock protein, putative 0.004 0.1937 0.3466
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.7766 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0863 0.1613
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.7766 0.7737
Echinococcus granulosus caspase 3 0.0073 0.6397 0.635
Plasmodium vivax heat shock protein 86, putative 0.0065 0.5349 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.014 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0052 0.3552 0.6558
Leishmania major DNA polymerase eta, putative 0.0032 0.0863 0.1613
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.2698 0.3474
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.014 0.0262
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.5349 1
Schistosoma mansoni DNA polymerase eta 0.0045 0.2698 0.2604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0127 0.0164
Trypanosoma cruzi heat shock protein, putative 0.0027 0.014 0.0262
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Schistosoma mansoni hypothetical protein 0.0083 0.7766 0.7737
Plasmodium falciparum heat shock protein 90 0.0065 0.5349 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.3552 0.5
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Echinococcus multilocularis heat shock protein 0.0065 0.5349 0.5289
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.014 0.0262
Trypanosoma cruzi metacaspase, putative 0.0027 0.0127 0.0238
Schistosoma mansoni caspase-7 (C14 family) 0.0099 1 1
Schistosoma mansoni heat shock protein 0.0065 0.5349 0.5289
Brugia malayi Endoplasmin precursor 0.0065 0.5349 0.6888
Echinococcus multilocularis caspase 3 0.0073 0.6397 0.635
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.7766 0.7737
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0127 0.0164
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.7766 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.7766 0.7737
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.5349 1
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.4019 0.3942
Trypanosoma cruzi metacaspase, putative 0.0027 0.0127 0.0238
Trichomonas vaginalis heat shock protein, putative 0.0052 0.3552 0.6558
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.5349 1
Echinococcus multilocularis dna polymerase eta 0.0045 0.2698 0.2604
Trypanosoma brucei metacaspase 0.0027 0.0127 0.0238
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0127 0.0238
Treponema pallidum heat shock protein 90 0.0052 0.3552 0.5
Schistosoma mansoni heat shock protein 0.0065 0.5349 0.5289
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.3552 0.5
Plasmodium vivax heat shock protein 90, putative 0.0027 0.014 0.0262
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.5349 1
Schistosoma mansoni heat shock protein 0.0027 0.014 0.0013
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.5349 1
Schistosoma mansoni endoplasmin 0.0065 0.5349 0.5289
Trypanosoma brucei metacaspase MCA2 0.0027 0.0127 0.0238
Plasmodium falciparum metacaspase 1 0.0027 0.0127 0.0238
Leishmania major metacaspase, putative 0.0027 0.0127 0.0238
Echinococcus multilocularis caspase 0.0099 1 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.7766 0.7737
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.2698 0.5044
Loa Loa (eye worm) heat shock protein 90 0.0065 0.5349 0.6888
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0127 0.0238
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.2698 0.5044
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Schistosoma mansoni apoptosis regulator bax 0.0083 0.7766 0.7737
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0127 0.0238
Leishmania major DNA polymerase eta, putative 0.0045 0.2698 0.5044
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.014 0.0262
Echinococcus granulosus heat shock protein 90 0.0052 0.3552 0.3469
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0127 0.0238
Trypanosoma brucei Metacaspase-4 0.0027 0.0127 0.0238
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0127 0.0238
Trichomonas vaginalis heat shock protein, putative 0.0065 0.5349 1
Echinococcus granulosus endoplasmin 0.0052 0.3552 0.3469
Echinococcus granulosus heat shock protein 0.0065 0.5349 0.5289
Schistosoma mansoni lipoxygenase 0.0055 0.4019 0.3942
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.5349 1
Schistosoma mansoni caspase-3 (C14 family) 0.0099 1 1
Schistosoma mansoni hypothetical protein 0.0083 0.7766 0.7737
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0863 0.1613
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.014 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.5349 1
Leishmania major heat shock protein, putative 0.0027 0.014 0.0262
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.3552 0.664
Echinococcus granulosus heat shock protein 90 0.0065 0.5349 0.5289
Brugia malayi Cell death protein 3 precursor 0.0027 0.0127 0.0164
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.014 0.0262
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.3552 0.3469
Trypanosoma cruzi metacaspase, putative 0.0027 0.0127 0.0238
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.3552 0.5
Schistosoma mansoni hypothetical protein 0.0083 0.7766 0.7737
Toxoplasma gondii heat shock protein HSP90 0.0065 0.5349 1
Echinococcus multilocularis endoplasmin 0.0052 0.3552 0.3469
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.014 0.0262
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.7766 0.7737
Echinococcus granulosus dna polymerase eta 0.0045 0.2698 0.2604
Plasmodium falciparum metacaspase-like protein 0.0027 0.0127 0.0238
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.5349 1
Loa Loa (eye worm) endoplasmin 0.0065 0.5349 0.6888
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.3552 0.664
Trichomonas vaginalis endoplasmin, putative 0.004 0.1937 0.3466
Trichomonas vaginalis heat shock protein, putative 0.0027 0.014 0.0025
Schistosoma mansoni endoplasmin 0.0065 0.5349 0.5289
Echinococcus multilocularis heat shock protein 90 0.0065 0.5349 0.5289
Trypanosoma brucei metacaspase MCA3 0.0027 0.0127 0.0238
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.1733 0.324
Brugia malayi Hsp90 protein 0.0027 0.014 0.018
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Echinococcus multilocularis heat shock protein 90 0.0052 0.3552 0.3469
Loa Loa (eye worm) hypothetical protein 0.0027 0.0127 0.0164
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Plasmodium falciparum endoplasmin, putative 0.004 0.1937 0.3622
Mycobacterium ulcerans heat shock protein 90 0.0052 0.3552 0.5
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.7766 1
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.2698 0.3474
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.4019 0.3942
Trichomonas vaginalis heat shock protein, putative 0.0052 0.3552 0.6558
Trypanosoma cruzi metacaspase, putative 0.0027 0.0127 0.0238
Leishmania major heat shock protein 83-1 0.0065 0.5349 1
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0127 0.0238
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.014 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.5349 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0127 0.0238
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.5349 1
Plasmodium vivax metacaspase 1, putative 0.0027 0.0127 0.0238
Trypanosoma brucei heat shock protein, putative 0.0065 0.5349 1
Plasmodium vivax endoplasmin, putative 0.0065 0.5349 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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