Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0091 | 0.5374 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0099 | 0.6038 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0091 | 0.5374 | 0.5374 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5374 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5374 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1904 | 0.1904 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0032 | 0.0504 | 0.5 |
Onchocerca volvulus | 0.0148 | 1 | 0.5 | |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0099 | 0.6038 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1904 | 0.1904 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5374 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.6038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5374 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0091 | 0.5374 | 1 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0029 | 0.0317 | 0.0589 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0099 | 0.6038 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1904 | 0.1904 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0643 | 0.0643 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.6038 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5374 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0099 | 0.6038 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0091 | 0.5374 | 0.5374 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.003 | 0.0388 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1904 | 0.1904 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0091 | 0.5374 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0091 | 0.5374 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.006 | 0.2787 | 0.4617 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0643 | 0.0643 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0099 | 0.6038 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.