TDR Targets

Basic information

Technical information

TDR Targets ID: 831722
Name: N-(3,5-dichlorophenyl)-3-(2,5,7-trimethyl-[1, 2,4]triazolo[1,5-a]pyrimidin-6-yl)propanamide
MW: 378.256 | Formula: C17H17Cl2N5O
H donors: 1 H acceptors: 4 LogP: 3.62 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(Cl)cc(c1)Cl)CCc1c(C)nc2n(c1C)nc(n2)C
InChi: 1S/C17H17Cl2N5O/c1-9-15(10(2)24-17(20-9)21-11(3)23-24)4-5-16(25)22-14-7-12(18)6-13(19)8-14/h6-8H,4-5H2,1-3H3,(H,22,25)
InChiKey: BNWTWPPTQUMHEZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,5-dichlorophenyl)-3-(2,5,7-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0196	0.033	0.0799
Loa Loa (eye worm)	G-protein coupled receptor	0.0196	0.033	0.0908
Echinococcus granulosus	tm gpcr rhodopsin	0.0196	0.033	0.0295
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0196	0.033	0.0295
Echinococcus multilocularis	allatostatin A receptor	0.0196	0.033	0.0295
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	histamine h1 receptor	0.0196	0.033	0.0799
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.017	0.0271	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0265	0.049	0.1352
Onchocerca volvulus		0.013	0.0176	0.0565
Brugia malayi	sulfakinin receptor protein	0.0196	0.033	0.0908
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Onchocerca volvulus		0.0189	0.0313	0.1119
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.017	0.0271	0.0744
Brugia malayi	Trypsin family protein	0.017	0.0271	0.0744
Echinococcus multilocularis	voltage dependent calcium channel	0.0095	0.0094	0.0059
Schistosoma mansoni	opsin-like receptor	0.0196	0.033	0.0799
Echinococcus multilocularis	sex peptide receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	trypsin family protein	0.017	0.0271	0.0744
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0095	0.0094	0.0059
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Loa Loa (eye worm)	hypothetical protein	0.017	0.0271	0.0744
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	7TM GPCR rhodopsin	0.0196	0.033	0.0295
Onchocerca volvulus		0.013	0.0176	0.0565
Onchocerca volvulus		0.0196	0.033	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Onchocerca volvulus		0.0196	0.033	0.1186
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0313	0.0862
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Echinococcus multilocularis	neuropeptides capa receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0224	0.0615
Brugia malayi	Integrin beta pat-3 precursor	0.1602	0.3607	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0382	0.1054
Echinococcus multilocularis	neuropeptide Y receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	integrin alpha ps	0.0151	0.0224	0.0189
Schistosoma mansoni	integrin beta subunit	0.0938	0.206	0.499
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	neuropeptide F receptor	0.0196	0.033	0.0908
Echinococcus multilocularis	g protein coupled receptor	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Onchocerca volvulus		0.0189	0.0313	0.1119
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Schistosoma mansoni	hypothetical protein	0.017	0.0271	0.0655
Echinococcus granulosus	neuropeptide FF receptor 2	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0721	0.1555	0.4307
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0196	0.033	0.0295
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0196	0.033	0.0295
Schistosoma mansoni	integrin alpha-ps	0.0164	0.0254	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	neuropeptide receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0441	0.0902	0.2496
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0196	0.033	0.0295
Echinococcus granulosus	tissue type plasminogen activator	0.0252	0.0461	0.0427
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0095	0.0094	0.0059
Echinococcus granulosus	neuropeptide Y receptor	0.0196	0.033	0.0295
Echinococcus granulosus	g protein coupled receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	tissue type plasminogen activator	0.0252	0.0461	0.0427
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0313	0.0862
Schistosoma mansoni	biogenic amine receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	neuropeptide F receptor	0.0196	0.033	0.0908
Echinococcus granulosus	integrin alpha 3	0.0428	0.0872	0.0839
Schistosoma mansoni	amine GPCR	0.0196	0.033	0.0799
Brugia malayi	Trypsin family protein	0.1134	0.2517	0.6976
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0095	0.0094	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0196	0.033	0.0799
Schistosoma mansoni	voltage-gated cation channel	0.0095	0.0094	0.0228
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0196	0.033	0.0295
Schistosoma mansoni	amine GPCR	0.0196	0.033	0.0799
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0271	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0278	0.0521	0.1438
Echinococcus granulosus	dro:myosuppressin receptor	0.0196	0.033	0.0295
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Schistosoma mansoni	hypothetical protein	0.017	0.0271	0.0655
Onchocerca volvulus		0.0189	0.0313	0.1119
Echinococcus granulosus	g-protein coupled receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Onchocerca volvulus		0.017	0.0271	0.0948
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Brugia malayi	Kelch motif family protein	0.0265	0.049	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	Melatonin receptor type 1A	0.0196	0.033	0.0908
Trypanosoma cruzi	hypothetical protein, conserved	0.0252	0.0461	0.2932
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0196	0.033	0.0295
Loa Loa (eye worm)	melatonin receptor type 1A	0.0196	0.033	0.0908
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0196	0.033	0.0295
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	putative neuropeptide receptor	0.0196	0.033	0.0908
Echinococcus granulosus	integrin alpha ps	0.0151	0.0224	0.0189
Onchocerca volvulus		0.0252	0.0461	0.1715
Onchocerca volvulus		0.0218	0.0382	0.1399
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0196	0.033	0.0799
Brugia malayi	Serotonin receptor	0.0196	0.033	0.0908
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.007	0.0035	0.0091
Schistosoma mansoni	neuropeptide f receptor 76f	0.0196	0.033	0.0799
Echinococcus multilocularis	fmrfamide receptor	0.0196	0.033	0.0295
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	neuropeptide receptor A26	0.0196	0.033	0.0295
Onchocerca volvulus		0.017	0.0271	0.0948
Brugia malayi	Dopamine receptor	0.0196	0.033	0.0908
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0196	0.033	0.0799
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.017	0.0271	0.0236
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Schistosoma mansoni	amine GPCR	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0271	0.0655
Echinococcus granulosus	orexin receptor type 2	0.0196	0.033	0.0295
Brugia malayi	G-protein coupled receptor	0.0196	0.033	0.0908
Echinococcus granulosus	Mastin	0.017	0.0271	0.0236
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.0035	0.0086
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.017	0.0271	0.0236
Schistosoma mansoni	serine-type protease inhibitor	0.1825	0.4128	1
Brugia malayi	RE15519p	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	hypothetical protein	0.0245	0.0445	0.1227
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Echinococcus multilocularis	orexin receptor type 2	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.1134	0.2517	0.6976
Echinococcus granulosus	fmrfamide receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Echinococcus granulosus	somatostatin receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0196	0.033	0.0295
Toxoplasma gondii	kringle domain-containing protein	0.0252	0.0461	0.0331
Schistosoma mansoni	integrin alpha-ps	0.0314	0.0605	0.1466
Echinococcus multilocularis	neuropeptide receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Onchocerca volvulus		0.017	0.0271	0.0948
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0252	0.0461	0.5
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Schistosoma mansoni	hypothetical protein	0.0196	0.033	0.0799
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0196	0.033	0.0908
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0196	0.033	0.0799
Loa Loa (eye worm)	integrin alpha pat-2	0.0756	0.1635	0.4528
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Brugia malayi	Cation transporter family protein	0.007	0.0035	0.0091
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Echinococcus granulosus	tm gpcr rhodopsin	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Loa Loa (eye worm)	G-protein coupled receptor	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0095	0.0094	0.0059
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Onchocerca volvulus		0.0196	0.033	0.1186
Echinococcus granulosus	G protein coupled receptor 139	0.0196	0.033	0.0295
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.007	0.0035	0.0091
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0196	0.033	0.0295
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.007	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Echinococcus granulosus	neuropeptide s receptor	0.0196	0.033	0.0295
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1134	0.2517	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Echinococcus multilocularis	Mastin	0.017	0.0271	0.0236
Schistosoma mansoni	neuropeptide F-like receptor	0.0196	0.033	0.0799
Echinococcus multilocularis	integrin beta 2	0.1183	0.2632	0.2606
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0319	0.0878
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0271	0.0655
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0903	0.1977	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	amine GPCR	0.0196	0.033	0.0799
Loa Loa (eye worm)	DOMON domain-containing protein	0.013	0.0176	0.048
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0313	0.0862
Brugia malayi	Serotonin receptor	0.0196	0.033	0.0908
Echinococcus granulosus	biogenic amine 5HT receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	voltage dependent calcium channel	0.0095	0.0094	0.0059
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0271	0.0655
Echinococcus multilocularis	integrin alpha 3	0.0428	0.0872	0.0839
Schistosoma mansoni	hypothetical protein	0.013	0.0176	0.0425
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.017	0.0271	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Schistosoma mansoni	adenoreceptor	0.0196	0.033	0.0799
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Schistosoma mansoni	biogenic amine receptor	0.0196	0.033	0.0799
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.007	0.0035	0.0091
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.007	0.0035	0.0091
Onchocerca volvulus		0.0189	0.0313	0.1119
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.0035	0.0086
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0196	0.033	0.0908
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0095	0.0094	0.0059
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0196	0.033	0.0908
Echinococcus multilocularis	dro:myosuppressin receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0196	0.033	0.0295
Onchocerca volvulus		0.0189	0.0313	0.1119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Echinococcus granulosus	integrin beta 2	0.1183	0.2632	0.2606
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0196	0.033	0.0799
Onchocerca volvulus		0.0196	0.033	0.1186
Echinococcus granulosus	enteropeptidase	0.017	0.0271	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Schistosoma mansoni	hypothetical protein	0.0196	0.033	0.0799
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Brugia malayi	Trypsin family protein	0.017	0.0271	0.0744
Loa Loa (eye worm)	neuropeptide F receptor	0.0196	0.033	0.0908
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0196	0.033	0.0908
Onchocerca volvulus		0.021	0.0362	0.1315
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus multilocularis	somatostatin receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	TYRA-2 protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.017	0.0271	0.0744
Loa Loa (eye worm)	hypothetical protein	0.017	0.0271	0.0744
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.007	0.0035	0.0091
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.007	0.0035	0.0091
Toxoplasma gondii	PAN domain-containing protein	0.2106	0.4781	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Brugia malayi	G protein-coupled receptor	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0461	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0218	0.0382	0.0926
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0196	0.033	0.0295
Schistosoma mansoni	opsin-like receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0313	0.0862
Brugia malayi	ORL1-like opioid receptor	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.017	0.0271	0.0744
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0196	0.033	0.0799
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Onchocerca volvulus		0.0196	0.033	0.1186
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.007	0.0035	0.0091
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0095	0.0094	0.0254
Onchocerca volvulus		0.013	0.0176	0.0565
Brugia malayi	SEA domain containing protein	0.013	0.0176	0.048
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Echinococcus granulosus	serotonin receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.021	0.0362	0.0996
Echinococcus granulosus	neuropeptides capa receptor	0.0196	0.033	0.0295
Schistosoma mansoni	neuropeptide receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.1134	0.2517	0.6976
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Echinococcus multilocularis	serotonin receptor	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Schistosoma mansoni	neuropeptide receptor	0.0196	0.033	0.0799
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0196	0.033	0.0295
Echinococcus granulosus	integrin alpha ps	0.0314	0.0605	0.0572
Loa Loa (eye worm)	LGC-31 protein	0.007	0.0035	0.0091
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.007	0.0035	0.0091
Brugia malayi	Cation transporter family protein	0.0218	0.0382	0.1054
Brugia malayi	AKH receptor	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Echinococcus multilocularis	serotonin receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	g protein coupled receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Toxoplasma gondii	PAN domain-containing protein	0.2106	0.4781	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0254	0.0699
Onchocerca volvulus		0.0189	0.0313	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Onchocerca volvulus		0.013	0.0176	0.0565
Loa Loa (eye worm)	hypothetical protein	0.013	0.0176	0.048
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.017	0.0271	0.0744
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.0035	0.0091
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0218	0.0382	0.0926
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.007	0.0035	0.0091
Loa Loa (eye worm)	integrin beta-2	0.1602	0.3607	1
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	Kringle domain containing protein	0.0252	0.0461	0.1272
Echinococcus multilocularis	neuropeptide s receptor	0.0196	0.033	0.0295
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0721	0.1555	1
Brugia malayi	Muscle positioning protein 4	0.013	0.0176	0.048
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0196	0.033	0.0908
Schistosoma mansoni	neuropeptide receptor	0.0196	0.033	0.0799
Echinococcus granulosus	hypothetical protein	0.0196	0.033	0.0295
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.007	0.0035	0.0091
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.007	0.0035	0.0086
Onchocerca volvulus		0.017	0.0271	0.0948
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	calcium channel	0.0095	0.0094	0.0254
Onchocerca volvulus		0.0218	0.0382	0.1399
Brugia malayi	Dopamine receptor protein 1	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	g protein coupled receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus multilocularis	g-protein coupled receptor	0.0196	0.033	0.0295
Schistosoma mansoni	hypothetical protein	0.0252	0.0461	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Onchocerca volvulus		0.0196	0.033	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0313	0.0862
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0095	0.0094	0.0228
Echinococcus multilocularis	G protein coupled receptor 139	0.0196	0.033	0.0295
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Schistosoma mansoni	serine-type protease inhibitor	0.1825	0.4128	1
Schistosoma mansoni	myosin xvIII	0.0196	0.033	0.0799
Echinococcus multilocularis	neuropeptides capa receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	allatostatin A receptor	0.0196	0.033	0.0295
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0721	0.1555	0.4307
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0196	0.033	0.0295
Schistosoma mansoni	hypothetical protein	0.0196	0.033	0.0799
Onchocerca volvulus		0.0189	0.0313	0.1119
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0721	0.1555	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Brugia malayi	putative neuropeptide receptor NPR1	0.0196	0.033	0.0908
Echinococcus multilocularis	g protein coupled receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0196	0.033	0.0908
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0095	0.0094	0.0059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0196	0.033	0.0295
Echinococcus multilocularis	integrin alpha ps	0.0314	0.0605	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0382	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	ACC-1 protein	0.007	0.0035	0.0091
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.0035	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0094	0.0254
Echinococcus multilocularis	glycoprotein Antigen 5	0.017	0.0271	0.0236
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Onchocerca volvulus		0.0964	0.212	0.8399
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	neuropeptide receptor	0.0196	0.033	0.0295
Onchocerca volvulus		0.017	0.0271	0.0948
Echinococcus granulosus	voltage dependent calcium channel	0.0095	0.0094	0.0059
Brugia malayi	GnHR receptor homolog	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.013	0.0176	0.048
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0196	0.033	0.0799
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Echinococcus multilocularis	fmrfamide receptor	0.0196	0.033	0.0295
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.4344	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0196	0.033	0.0295
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0445	0.1227
Echinococcus granulosus	neuropeptide Y receptor	0.0196	0.033	0.0295
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0196	0.033	0.0799
Schistosoma mansoni	hypothetical protein	0.0151	0.0224	0.0543
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	TK/ROR protein kinase	0.0252	0.0461	0.1272
Brugia malayi	solute carrier family 40, member 1	0.021	0.0362	0.0996
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.007	0.0035	0.0091
Onchocerca volvulus		0.0196	0.033	0.1186
Brugia malayi	Integrin alpha pat-2 precursor	0.0592	0.1253	0.347
Onchocerca volvulus		0.0189	0.0313	0.1119
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0196	0.033	0.0295
Onchocerca volvulus		0.0196	0.033	0.1186
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.0035	0.0091
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Onchocerca volvulus		0.0196	0.033	0.1186
Schistosoma mansoni	integrin alpha	0.0592	0.1253	0.3035
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0314	0.0606	0.1673
Schistosoma mansoni	biogenic amine receptor	0.0196	0.033	0.0799
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0369	0.0733	0.2026
Echinococcus granulosus	glycoprotein Antigen 5	0.017	0.0271	0.0236
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Schistosoma mansoni	hypothetical protein	0.0196	0.033	0.0799
Onchocerca volvulus		0.1134	0.2517	1
Echinococcus multilocularis	enteropeptidase	0.017	0.0271	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	G-protein coupled receptor	0.0196	0.033	0.0908
Echinococcus multilocularis	neuropeptide receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	Cation transporter family protein	0.007	0.0035	0.0091
Schistosoma mansoni	growth hormone secretagogue receptor	0.0196	0.033	0.0799
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Onchocerca volvulus		0.0189	0.0313	0.1119
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.0035	0.0091
Brugia malayi	hypothetical protein	0.017	0.0271	0.0744
Brugia malayi	larval opioid receptor	0.0196	0.033	0.0908
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1177	0.2617	0.6339
Brugia malayi	Trypsin-like protease protein 5	0.017	0.0271	0.0744
Echinococcus granulosus	sex peptide receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	g protein coupled receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Echinococcus granulosus	neuropeptide receptor	0.0196	0.033	0.0295
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0196	0.033	0.1186
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	neuropeptides capa receptor	0.0196	0.033	0.0295
Echinococcus granulosus	transmembrane protease serine 3	0.017	0.0271	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Echinococcus multilocularis	integrin alpha ps	0.0314	0.0605	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0314	0.0606	0.1673
Brugia malayi	neuropeptide F receptor	0.0196	0.033	0.0908
Mycobacterium ulcerans	hypothetical protein	0.017	0.0271	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.0035	0.0091
Echinococcus multilocularis	neuropeptide Y receptor	0.0196	0.033	0.0295
Loa Loa (eye worm)	ACC-1 protein	0.007	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Schistosoma mansoni	integrin alpha-4	0.0378	0.0754	0.1825
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0313	0.0862
Brugia malayi	PAN domain containing protein	0.0189	0.0313	0.0862
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0196	0.033	0.0295
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0095	0.0094	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	neuropeptide receptor A26	0.0196	0.033	0.0295
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0196	0.033	0.0799
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0196	0.033	0.0295
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0196	0.033	0.0799
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Plasmodium falciparum	cysteine repeat modular protein 1	0.0252	0.0461	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0196	0.033	0.0908
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0095	0.0094	0.0059
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.007	0.0035	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Brugia malayi	G protein-coupled receptor F59B2.13	0.0196	0.033	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Leishmania major	C-8 sterol isomerase-like protein	0.0721	0.1555	1
Schistosoma mansoni	opsin-like receptor	0.0196	0.033	0.0799
Brugia malayi	Protein kinase domain containing protein	0.0252	0.0461	0.1272
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.019	0.0316	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Onchocerca volvulus		0.0218	0.0382	0.1399
Brugia malayi	hypothetical protein	0.0196	0.033	0.0908
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0196	0.033	0.1186
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0196	0.033	0.0908
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Echinococcus multilocularis	transmembrane protease serine 3	0.017	0.0271	0.0236
Schistosoma mansoni	cercarial elastase (S01 family)	0.017	0.0271	0.0655
Brugia malayi	follicle stimulating hormone receptor	0.0196	0.033	0.0908
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0196	0.033	0.0908
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.0035	0.0091
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.017	0.0271	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0196	0.033	0.0908
Echinococcus granulosus	biogenic amine 5HT receptor	0.0196	0.033	0.0295
Brugia malayi	Trypsin family protein	0.017	0.0271	0.0744
Onchocerca volvulus		0.013	0.0176	0.0565
Onchocerca volvulus		0.0189	0.0313	0.1119
Loa Loa (eye worm)	hypothetical protein	0.007	0.0035	0.0091
Schistosoma mansoni	neuropeptide F-like receptor	0.0196	0.033	0.0799
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0196	0.033	0.0799
Brugia malayi	Dopamine receptor protein 2	0.0196	0.033	0.0908
Onchocerca volvulus		0.0189	0.0313	0.1119
Brugia malayi	excitatory GABA receptor EXP-1A	0.007	0.0035	0.0091
Schistosoma mansoni	nAChR subunit	0.007	0.0035	0.0086
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.0035	0.0091
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0196	0.033	0.0799
Onchocerca volvulus		0.0196	0.033	0.1186

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 831722