Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0087 | 0.0058 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0087 | 0.0087 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0087 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0029 | 0.0029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0602 | 0.0575 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.043 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1029 | 0.1003 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.025 | 0.0222 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0199 | 0.3538 | 0.3519 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0536 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.043 | 0.0403 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0602 | 0.0575 |
Leishmania major | 0.0536 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.075 | 0.0723 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1029 | 0.1029 |
Echinococcus multilocularis | musashi | 0.0028 | 0.025 | 0.0222 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0602 | 0.0575 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0536 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.043 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3093 | 0.3073 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.043 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.043 | 0.0403 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0087 | 0.0058 |
Echinococcus multilocularis | geminin | 0.0176 | 0.3093 | 0.3073 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.043 | 0.0403 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1029 | 0.1003 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0087 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0199 | 0.3538 | 0.3519 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0087 | 0.0058 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1029 | 0.1003 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.025 | 0.025 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.025 | 0.025 |
Schistosoma mansoni | lamin | 0.0028 | 0.025 | 0.0222 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0355 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0474 | 0.0447 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.1029 | 0.1003 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0536 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0087 | 0.5 |
Echinococcus granulosus | geminin | 0.0176 | 0.3093 | 0.3073 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.043 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0087 | 0.0058 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0536 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0602 | 0.0575 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.043 | 0.043 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.025 | 0.0222 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.043 | 0.3647 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.1029 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0536 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1029 | 0.1003 |
Onchocerca volvulus | 0.0158 | 0.2744 | 1 | |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0199 | 0.3538 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.024 | 0.024 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.043 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0602 | 0.0575 |
Echinococcus granulosus | lamin | 0.0028 | 0.025 | 0.0222 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0536 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0087 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.025 | 0.025 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0029 | 0.0029 |
Brugia malayi | Inositol-1 | 0.0037 | 0.043 | 0.043 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3093 | 0.3073 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.043 | 0.0403 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0087 | 0.0087 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1029 | 0.1003 |
Brugia malayi | hypothetical protein | 0.0158 | 0.2744 | 0.2744 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0087 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2744 | 0.2744 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.025 | 0.025 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0602 | 0.0575 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0087 | 0.0058 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0087 | 0.1782 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.043 | 0.0403 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0199 | 0.3538 | 0.3519 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.025 | 0.0222 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0087 | 0.0058 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.025 | 0.025 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0087 | 0.0058 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.043 | 0.0403 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0536 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0536 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.043 | 0.0403 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.0355 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.025 | 0.0222 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0602 | 0.0602 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0087 | 0.0058 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.043 | 0.0403 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.1029 | 0.1029 |
Echinococcus multilocularis | lamin | 0.0028 | 0.025 | 0.0222 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.043 | 0.0403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0602 | 0.0575 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0602 | 0.0602 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0199 | 0.3538 | 0.3519 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1029 | 0.1003 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.025 | 0.0222 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0474 | 0.0447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.