Detailed information for compound 832127

Basic information

Technical information
  • TDR Targets ID: 832127
  • Name: N-(4-methylphenyl)-2-(2-oxopyrido[2,3-b][1,4] thiazin-1-yl)acetamide
  • MW: 313.374 | Formula: C16H15N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)CSc2c1cccn2)Nc1ccc(cc1)C
  • InChi: 1S/C16H15N3O2S/c1-11-4-6-12(7-5-11)18-14(20)9-19-13-3-2-8-17-16(13)22-10-15(19)21/h2-8H,9-10H2,1H3,(H,18,20)
  • InChiKey: JBCKGQMGHCOTKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-methylphenyl)-2-(2-oxo-1-pyrido[2,3-b][1,4]thiazinyl)acetamide
  • 2-(2-ketopyrido[2,3-b][1,4]thiazin-1-yl)-N-(4-methylphenyl)acetamide
  • N-(4-methylphenyl)-2-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)ethanamide
  • ChemDiv3_015542

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni plexin 0.0056 0.3634 0.7384
Brugia malayi Plexin repeat family protein 0.0056 0.3634 0.339
Loa Loa (eye worm) sema domain-containing protein 0.0024 0.0879 0.053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.3154 0.63
Brugia malayi RNA binding protein 0.007 0.4791 0.4591
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.3536 0.3289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.3154 0.63
Brugia malayi RNA recognition motif domain containing protein 0.007 0.4791 0.4591
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.3154 0.63
Echinococcus granulosus plexin a4 0.0067 0.45 0.9343
Echinococcus granulosus semaphorin 5B 0.0024 0.0879 0.1155
Loa Loa (eye worm) TAR-binding protein 0.007 0.4791 0.4591
Brugia malayi TAR-binding protein 0.007 0.4791 0.4591
Schistosoma mansoni tar DNA-binding protein 0.007 0.4791 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0879 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.3154 0.63
Entamoeba histolytica protein kinase domain containing protein 0.0013 0 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.3154 0.2892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.3154 0.63
Echinococcus multilocularis plexin a4 0.0067 0.45 0.9343
Schistosoma mansoni hypothetical protein 0.0038 0.207 0.3848
Schistosoma mansoni plexin 0.0033 0.1657 0.2913
Schistosoma mansoni tar DNA-binding protein 0.007 0.4791 1
Brugia malayi Sema domain containing protein 0.0024 0.0879 0.053
Schistosoma mansoni semaphorin 5-related 0.0024 0.0879 0.1155
Echinococcus multilocularis hypothetical protein 0.0024 0.0879 0.1155
Brugia malayi hypothetical protein 0.0024 0.0879 0.053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0879 0.053
Entamoeba histolytica tyrosin kinase, putative 0.0013 0 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.3154 0.2892
Schistosoma mansoni hypothetical protein 0.0033 0.1657 0.2913
Loa Loa (eye worm) plexin A 0.0067 0.45 0.429
Loa Loa (eye worm) hypothetical protein 0.0056 0.3634 0.339
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.1657 0.1338
Loa Loa (eye worm) sema domain-containing protein 0.0024 0.0879 0.053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0879 0.053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0879 0.053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.3536 0.3289
Schistosoma mansoni tar DNA-binding protein 0.007 0.4791 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.4791 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.3154 0.63
Loa Loa (eye worm) RNA binding protein 0.007 0.4791 0.4591
Onchocerca volvulus 0.0056 0.3634 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.4791 1
Brugia malayi hypothetical protein 0.0024 0.0879 0.053
Echinococcus granulosus tar DNA binding protein 0.007 0.4791 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.3154 0.63
Brugia malayi Sema domain containing protein 0.0024 0.0879 0.053
Brugia malayi plexin A 0.0067 0.45 0.429
Loa Loa (eye worm) hypothetical protein 0.0038 0.207 0.1767
Loa Loa (eye worm) hypothetical protein 0.0055 0.3536 0.3289
Echinococcus granulosus semaphorin 1A 0.0024 0.0879 0.1155
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.3536 0.3289
Loa Loa (eye worm) hypothetical protein 0.0024 0.0879 0.053
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.207 0.1767
Echinococcus multilocularis semaphorin 5B 0.0024 0.0879 0.1155
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.4791 0.4591
Loa Loa (eye worm) hypothetical protein 0.0024 0.0879 0.053
Schistosoma mansoni hypothetical protein 0.0024 0.0879 0.1155
Echinococcus multilocularis tar DNA binding protein 0.007 0.4791 1
Schistosoma mansoni hypothetical protein 0.0024 0.0879 0.1155
Loa Loa (eye worm) transcription factor SMAD2 0.0132 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.