Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.3154 | 0.63 |
Echinococcus multilocularis | plexin a4 | 0.0067 | 0.45 | 0.9343 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.4791 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.3536 | 0.3289 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4791 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.4791 | 0.4591 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.3154 | 0.63 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4791 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0024 | 0.0879 | 0.1155 |
Echinococcus multilocularis | semaphorin 5B | 0.0024 | 0.0879 | 0.1155 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.4791 | 0.4591 |
Schistosoma mansoni | semaphorin 5-related | 0.0024 | 0.0879 | 0.1155 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0879 | 0.1155 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3154 | 0.63 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0013 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.007 | 0.4791 | 0.4591 |
Onchocerca volvulus | 0.0056 | 0.3634 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0879 | 0.1155 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.207 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1657 | 0.1338 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.4791 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4791 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4791 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4791 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.207 | 0.1767 |
Echinococcus granulosus | semaphorin 5B | 0.0024 | 0.0879 | 0.1155 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.4791 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Brugia malayi | Sema domain containing protein | 0.0024 | 0.0879 | 0.053 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0024 | 0.0879 | 0.053 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Schistosoma mansoni | plexin | 0.0033 | 0.1657 | 0.2913 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3154 | 0.63 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.3154 | 0.63 |
Brugia malayi | RNA binding protein | 0.007 | 0.4791 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.3536 | 0.3289 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.3154 | 0.63 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Brugia malayi | Plexin repeat family protein | 0.0056 | 0.3634 | 0.339 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3154 | 0.63 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Brugia malayi | plexin A | 0.0067 | 0.45 | 0.429 |
Schistosoma mansoni | plexin | 0.0056 | 0.3634 | 0.7384 |
Loa Loa (eye worm) | plexin A | 0.0067 | 0.45 | 0.429 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.3154 | 0.2892 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0024 | 0.0879 | 0.053 |
Brugia malayi | Sema domain containing protein | 0.0024 | 0.0879 | 0.053 |
Echinococcus granulosus | plexin a4 | 0.0067 | 0.45 | 0.9343 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3536 | 0.3289 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.4791 | 0.4591 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.053 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.207 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3634 | 0.339 |
Echinococcus granulosus | semaphorin 1A | 0.0024 | 0.0879 | 0.1155 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.3536 | 0.3289 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1657 | 0.2913 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.3154 | 0.2892 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.