Detailed information for compound 835389

Basic information

Technical information
  • TDR Targets ID: 835389
  • Name: 3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)pr op-2-enamide
  • MW: 295.376 | Formula: C19H21NO2
  • H donors: 1 H acceptors: 1 LogP: 3.99 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=CC(=O)NC(Cc1ccccc1)C
  • InChi: 1S/C19H21NO2/c1-15(14-17-6-4-3-5-7-17)20-19(21)13-10-16-8-11-18(22-2)12-9-16/h3-13,15H,14H2,1-2H3,(H,20,21)/b13-10+
  • InChiKey: QRSXJWFJZOGNPC-JLHYYAGUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)prop-2-enamide
  • 3-(4-methoxyphenyl)-N-(1-methyl-2-phenyl-ethyl)prop-2-enamide
  • (E)-3-(4-methoxyphenyl)-N-(1-methyl-2-phenyl-ethyl)prop-2-enamide
  • (E)-3-(4-methoxyphenyl)-N-(1-methyl-2-phenylethyl)prop-2-enamide
  • 3-(4-methoxyphenyl)-N-(1-methyl-2-phenylethyl)prop-2-enamide
  • (E)-3-(4-methoxyphenyl)-N-(1-methyl-2-phenyl-ethyl)acrylamide
  • 3-(4-methoxyphenyl)-N-(1-methyl-2-phenyl-ethyl)acrylamide
  • CBMicro_018582
  • BIM-0018801.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Onchocerca volvulus Carboxypeptidase D homolog 0.0063 0.0439 0.1828
Onchocerca volvulus 0.0174 0.2402 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0 0.5
Toxoplasma gondii PAN domain-containing protein 0.0286 0.4373 1
Onchocerca volvulus 0.0174 0.2402 1
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0038 0 0.5
Onchocerca volvulus 0.0174 0.2402 1
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0038 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0439 0.0439
Trypanosoma brucei Carboxypeptidase-like protein 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0136 0.1739 0.1739
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0038 0 0.5
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0038 0 0.5
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0038 0 0.5
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Trypanosoma cruzi Carboxypeptidase-like protein 0.0038 0 0.5
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0038 0 0.5
Loa Loa (eye worm) zinc carboxypeptidase 0.0063 0.0439 0.0439
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0174 0.2402 1
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0038 0 0.5
Mycobacterium ulcerans epoxide hydrolase EphA 0.016 0.2156 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0038 0 0.5
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0174 0.2402 1
Brugia malayi Zinc carboxypeptidase family protein 0.0063 0.0439 0.0439
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.016 0.2156 0.5
Onchocerca volvulus 0.0174 0.2402 1
Toxoplasma gondii PAN domain-containing protein 0.0286 0.4373 1
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0038 0 0.5
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0038 0 0.5
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0605 1 1
Brugia malayi Zinc carboxypeptidase family protein 0.0063 0.0439 0.0439
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0174 0.2402 1
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0174 0.2402 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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