Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Brugia malayi | hypothetical protein | 0.0272 | 0.3026 | 0.7389 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.0794 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.0794 | 0.0749 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0061 | 0.0049 | 0.000000050689 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0055 | 0.0014 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.0794 | 0.1913 |
Echinococcus granulosus | Ankyrin | 0.0062 | 0.0055 | 0.0005 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.0794 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.3943 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.0794 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0062 | 0.0055 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.0049 | 0.0156 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.0794 | 0.2513 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.0794 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0281 | 0.316 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.0794 | 0.2503 |
Brugia malayi | bZIP transcription factor family protein | 0.0346 | 0.4078 | 1 |
Echinococcus granulosus | jun protein | 0.0346 | 0.4078 | 0.4048 |
Echinococcus multilocularis | jun protein | 0.0346 | 0.4078 | 0.4048 |
Schistosoma mansoni | jun-related protein | 0.0281 | 0.316 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.0794 | 0.0749 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.0794 | 0.1849 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.0794 | 0.5 |
Brugia malayi | Uncoordinated protein 44 | 0.0061 | 0.0049 | 0.00000012521 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0062 | 0.0054 | 0.0013 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0061 | 0.0049 | 0.000000050689 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0346 | 0.4078 | 0.4048 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0764 | 1 | 1 |
Schistosoma mansoni | netrin receptor unc5 | 0.0061 | 0.0049 | 0.0156 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0062 | 0.0055 | 0.0172 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0794 | 0.5 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0061 | 0.0049 | 0.0156 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.0794 | 0.5 |
Onchocerca volvulus | 0.0272 | 0.3026 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0346 | 0.4078 | 0.4048 |
Brugia malayi | Death domain containing protein | 0.0061 | 0.0049 | 0.00000012521 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.003 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.