Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1227 | 0.1227 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2758 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1227 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0203 | 0.0597 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1227 | 0.3502 |
Echinococcus multilocularis | jun protein | 0.0085 | 0.3504 | 0.3504 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.3504 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0085 | 0.3504 | 0.3504 |
Schistosoma mansoni | jun-related protein | 0.0069 | 0.2758 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0015 | 0.0203 | 0.0597 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0015 | 0.0203 | 0.0203 |
Brugia malayi | Death domain containing protein | 0.0015 | 0.0203 | 0.0578 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0015 | 0.0203 | 0.0203 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0015 | 0.0203 | 0.0203 |
Schistosoma mansoni | netrin receptor unc5 | 0.0015 | 0.0203 | 0.0734 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0208 | 0.0208 |
Onchocerca volvulus | Netrin receptor homolog | 0.0015 | 0.0203 | 0.0765 |
Echinococcus granulosus | jun protein | 0.0085 | 0.3504 | 0.3504 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0208 | 0.0756 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0085 | 0.3504 | 0.3504 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0203 | 0.0734 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1227 | 0.445 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0203 | 0.0578 |
Onchocerca volvulus | 0.0067 | 0.2649 | 1 | |
Brugia malayi | hypothetical protein | 0.0067 | 0.2649 | 0.7559 |
Brugia malayi | Uncoordinated protein 44 | 0.0015 | 0.0203 | 0.0578 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1227 | 0.1227 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1227 | 0.445 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0208 | 0.0614 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1227 | 0.5 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0208 | 0.0208 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0015 | 0.0203 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.3395 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0015 | 0.0203 | 0.0203 |
Echinococcus granulosus | death domain containing protein | 0.0015 | 0.0203 | 0.0203 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1227 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.0232 | 0.0661 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1227 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.