Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein | 0.0358 | 0.4023 | 1 |
Brugia malayi | hypothetical protein | 0.0125 | 0.111 | 0.2759 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0146 | 0.1369 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0219 | 0.2285 | 0.568 |
Onchocerca volvulus | 0.0358 | 0.4023 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1709 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0219 | 0.2285 | 0.568 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0299 | 0.3283 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0358 | 0.4023 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0299 | 0.3283 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.111 | 0.2759 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0086 | 0.0614 | 0.1526 |
Trypanosoma brucei | phospholipase A1, putative | 0.0358 | 0.4023 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0146 | 0.1369 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0219 | 0.2285 | 0.568 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0614 | 0.1526 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.111 | 0.2759 |
Onchocerca volvulus | 0.0358 | 0.4023 | 1 | |
Leishmania major | phospholipase A1, putative | 0.0358 | 0.4023 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0086 | 0.0614 | 0.0614 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1709 | 0.1709 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0164 | 0.1597 | 0.3969 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.111 | 0.1455 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0219 | 0.2285 | 0.568 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0358 | 0.4023 | 1 |
Onchocerca volvulus | 0.0358 | 0.4023 | 1 | |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.0164 | 0.1597 | 0.3969 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0358 | 0.4023 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.1709 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0086 | 0.0614 | 0.3591 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1709 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0299 | 0.3283 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0086 | 0.0614 | 0.3591 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0146 | 0.1369 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.111 | 0.1455 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0000000103 M | Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells | ChEMBL. | 8627615 |
EC50 (binding) | = 0.000000146 M | Affinity for estrogen receptor | ChEMBL. | 8627615 |
EC50 (binding) | = 0.000000342 M | Affinity estrogen receptor of MCF-7 human mammary cancer cells | ChEMBL. | 8627615 |
EC50 (functional) | = 2.79 nM | Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells | ChEMBL. | 8627615 |
GI50 (functional) | = 23.4 uM | Growth inhibitory concentration required against human melanoma UACC-62 cancer cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 24 uM | Growth inhibitory concentration required against human breast MDA-MB-435 cancer cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 31.6 uM | Growth inhibitory concentration required against human ovarian OVCAR-3 cancer cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 34.7 uM | Average concentration required for 50% growth inhibition of human cancer cell line (tested) | ChEMBL. | 15456256 |
GI50 (functional) | = 38 uM | Growth inhibitory concentration required against human CNS SF-539 cancer cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 63.1 uM | Growth inhibitory concentration required for against human renal SN12C cancer cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 70.8 uM | Growth inhibitory concentration required against human prostate DU-145 cancer cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 72.4 uM | Growth inhibitory concentration against human lung cancer HOP-62 cell line | ChEMBL. | 15456256 |
GI50 (functional) | = 74.1 uM | Growth inhibitory concentration against human colon cancer HCT-116 cell line | ChEMBL. | 15456256 |
IC50 (functional) | = 7.73 uM | Inhibitory concentration required against growth of HUVEC cancer cell line | ChEMBL. | 15456256 |
IC50 (functional) | > 40 uM | Inhibitory concentration against bovine tubulin polymerization | ChEMBL. | 15456256 |
IC50 (functional) | = 99.25 uM | Inhibitory concentration against growth of MDA-MB-231 cancer cell line | ChEMBL. | 15456256 |
RBA (binding) | = 0.68 | Relative binding affinity(RBA) of estradiol with respect to compound (using estrogen receptor preparations) | ChEMBL. | 8627615 |
RBA (binding) | = 1.11 | Relative binding affinity for estrogen receptor compared to estradiol | ChEMBL. | 8627615 |
Relative activity (functional) | = 0.967 | Relative induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells compared to estradiol | ChEMBL. | 8627615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.