Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1788 | 0.1405 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0068 | 0.0446 | 0.0794 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.383 | 0.383 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Loa Loa (eye worm) | ctsf protein | 0.012 | 0.562 | 0.5415 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.383 | 0.383 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0068 | 0.0446 | 0.0446 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.383 | 0.6541 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.012 | 0.562 | 0.562 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0068 | 0.0446 | 0.0794 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.562 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 0.383 | 0.6816 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0082 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 0.383 | 0.383 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.383 | 0.383 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0163 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.012 | 0.562 | 0.562 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.012 | 0.562 | 0.5415 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.562 | 0.562 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.012 | 0.562 | 0.5415 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0082 | 0.1788 | 0.1788 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0068 | 0.0446 | 0.0446 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.6816 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 0.383 | 0.6816 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1788 | 0.1788 |
Brugia malayi | Cathepsin L-like precursor | 0.0082 | 0.1788 | 0.1788 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 0.383 | 0.383 |
Onchocerca volvulus | Cathepsin F homolog | 0.012 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.383 | 0.6541 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 0.383 | 0.6541 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1788 | 0.1405 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.562 | 0.562 |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.383 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 0.383 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.012 | 0.562 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.012 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 0.383 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.383 | 0.6816 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 0.383 | 0.533 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.562 | 0.5415 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0082 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1788 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1788 | 0.1405 |
Leishmania major | cysteine peptidase A (CPA) | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.383 | 0.6816 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0102 | 0.383 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0082 | 0.1788 | 0.1788 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.383 | 0.6816 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0082 | 0.1788 | 0.3182 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.383 | 0.383 |
Loa Loa (eye worm) | cysteine protease | 0.012 | 0.562 | 0.5415 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | fibroinase | 0.012 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.562 | 1 |
Onchocerca volvulus | 0.012 | 0.562 | 1 | |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0082 | 0.1788 | 0.1788 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0163 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.012 | 0.562 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 0.383 | 0.383 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.383 | 0.3542 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.012 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.012 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0082 | 0.1788 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.383 | 0.6816 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.562 | 0.562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.