Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0883 | 1 | 0.5 | |
Schistosoma mansoni | amidase | 0.0629 | 0.6855 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.015 | 0.0916 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.015 | 0.0916 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0076 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0883 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0883 | 1 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0883 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0629 | 0.6855 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0883 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0883 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0883 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0883 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0629 | 0.6855 | 0.6855 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0883 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0883 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0883 | 1 | 1 |
Brugia malayi | amidase | 0.0629 | 0.6855 | 0.6855 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.