Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.011 | 0.0084 | 0.0075 |
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.2451 | 0.2572 | 1 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.2451 | 0.2572 | 0.2565 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.9442 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0039 | 0.0009 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0039 | 0.0009 | 0.0019 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2451 | 0.2572 | 0.2565 |
Schistosoma mansoni | serine/threonine protein kinase | 0.9442 | 1 | 1 |
Echinococcus granulosus | RUN | 0.0039 | 0.0009 | 0.0019 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.0009 | 0.0019 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0039 | 0.0009 | 0.5 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.2451 | 0.2572 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0039 | 0.0009 | 0.0019 |
Brugia malayi | hypothetical protein | 0.8021 | 0.849 | 0.8488 |
Entamoeba histolytica | protein kinase, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.011 | 0.0084 | 0.0293 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.011 | 0.0084 | 0.0312 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.2451 | 0.2572 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.