Detailed information for compound 842079

Basic information

Technical information
  • TDR Targets ID: 842079
  • Name: 5-chloro-2-methoxy-N-propan-2-ylbenzamide
  • MW: 227.687 | Formula: C11H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 2.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)NC(C)C)Cl
  • InChi: 1S/C11H14ClNO2/c1-7(2)13-11(14)9-6-8(12)4-5-10(9)15-3/h4-7H,1-3H3,(H,13,14)
  • InChiKey: XNRMIULTBWTSOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-isopropyl-2-methoxy-benzamide
  • 5-chloro-N-isopropyl-2-methoxybenzamide
  • 5-chloro-2-methoxy-N-propan-2-yl-benzamide
  • ST043639
  • ZINC00030533
  • AE-641/11702997
  • MLS000680340
  • SMR000268642
  • BIM-0018636.P001
  • CBMicro_018765

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0417 0.0652
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0076 0.01
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0076 0.0057
Brugia malayi hypothetical protein 0.0035 0.024 0.0375
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0076 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0457 0.0715
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.008 0.0818 0.128
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0076 0.0432
Plasmodium vivax importin-beta 2, putative 0.0028 0.015 0.2001
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0076 0.0021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0058 0.0532 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0457 0.0634
Schistosoma mansoni hypothetical protein 0.0171 0.1988 0.5379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0457 0.1118
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0076 0.0432
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0115 0.1263 0.5848
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.0057
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0076 0.0021
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.008 0.0818 0.128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0457 0.0404
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0076 0.01
Loa Loa (eye worm) hypothetical protein 0.0089 0.0932 0.1385
Schistosoma mansoni hypothetical protein 0.0033 0.0218 0.0454
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0022 0.0076 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0076 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0033
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0116 0.0295
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0182 0.2121 0.575
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Giardia lamblia hypothetical protein 0.0022 0.0076 0.0046
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0082 0.0043
Brugia malayi RNA binding protein 0.0062 0.0587 0.0918
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0076 0.0057
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0116 0.1279
Entamoeba histolytica hypothetical protein 0.0023 0.0082 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0457 0.1118
Echinococcus granulosus tar DNA binding protein 0.0062 0.0587 0.148
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0076 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0532 0.0753
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1834 0.2808
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0116 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0082 0.0043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0818 0.1205
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0373 0.4571 0.7152
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0373 0.4571 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1292 0.1952
Schistosoma mansoni eyes absent homolog 0.0089 0.0932 0.2442
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0373 0.4571 0.7127
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Leishmania major hypothetical protein, conserved 0.0026 0.0116 0.0295
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0076 0.0021
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.01
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0076 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1263 0.5848
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0182 0.2121 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0076 0.0118
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Echinococcus multilocularis geminin 0.0171 0.1988 0.1943
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0116 0.0295
Brugia malayi RNA, U transporter 1 0.008 0.0817 0.1278
Toxoplasma gondii GAF domain-containing protein 0.0058 0.0532 0.268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0457 0.1118
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.008 0.0818 0.0768
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0417 0.0652
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0373 0.4571 1
Loa Loa (eye worm) PDE1B protein 0.0022 0.0076 0.0033
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0182 0.2121 0.2077
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0373 0.4571 0.7127
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0182 0.2121 1
Echinococcus granulosus snurportin 1 0.0301 0.3648 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Leishmania major hypothetical protein, conserved 0.0022 0.0076 0.01
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0115 0.1263 0.1907
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0076 0.01
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0076 0.0118
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0076 0.0432
Loa Loa (eye worm) hypothetical protein 0.0089 0.0932 0.1385
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0076 0.0118
Brugia malayi hypothetical protein 0.0089 0.0932 0.1459
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus multilocularis snurportin 1 0.0301 0.3648 0.3613
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0373 0.4571 0.7127
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0076 0.01
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Plasmodium falciparum GAF domain-related protein, putative 0.0058 0.0532 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0587 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1263 0.5848
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Leishmania major hypothetical protein, conserved 0.0115 0.1263 0.5848
Loa Loa (eye worm) RNA binding protein 0.0062 0.0587 0.0839
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus granulosus importin subunit beta 1 0.0028 0.015 0.0266
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3648 0.567
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0076 0.01
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0515 0.6392 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0515 0.6392 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.01
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0373 0.4571 0.7127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0457 0.1118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0457 0.0404
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.015 0.0462
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0587 0.0839
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4355 0.6785
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0587 0.0839
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0182 0.2121 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0082 0.0131
Loa Loa (eye worm) hypothetical protein 0.0049 0.0417 0.0571
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.008 0.0818 0.2125
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0218 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0417 0.0571
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Giardia lamblia Hypothetical protein 0.0022 0.0076 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0076 0.0033
Onchocerca volvulus 0.0373 0.4571 1
Schistosoma mansoni importin beta-1 0.0028 0.015 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1834 0.2808
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0115 0.1263 0.1907
Schistosoma mansoni hypothetical protein 0.0035 0.024 0.0515
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Brugia malayi Importin beta-1 subunit 0.0028 0.015 0.0235
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.2121 0.326
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0076 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.024 0.0515
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0182 0.2121 0.575
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0218 0.0257
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0082 0.0131
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0076 0.0432
Brugia malayi MH2 domain containing protein 0.0117 0.1292 0.2022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.024 0.0515
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0182 0.2121 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0076 0.0021
Loa Loa (eye worm) hypothetical protein 0.0058 0.0532 0.0753
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1292 0.1952
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0124 0.1378 0.2088
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0124 0.1378 0.6404
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4355 0.6785
Toxoplasma gondii hypothetical protein 0.0058 0.0532 0.268
Leishmania major hypothetical protein, conserved 0.0022 0.0076 0.01
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0587 0.0918
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.008 0.0818 0.2125
Schistosoma mansoni hypothetical protein 0.0171 0.1988 0.5379
Echinococcus granulosus geminin 0.0171 0.1988 0.5379
Toxoplasma gondii hypothetical protein 0.0159 0.1834 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0373 0.4571 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0258 0.3097 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii hypothetical protein 0.0058 0.0532 0.268
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0055 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0033
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.1205
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.01
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0076 0.0057
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.015 0.0536
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0124 0.1378 0.2088
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0116 0.1279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0457 0.1118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Brugia malayi TAR-binding protein 0.0062 0.0587 0.0918
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0076 0.0033
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.015 0.0462
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0373 0.4571 1
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0076 0.0057
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0076 0.0021
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0082 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1834 0.2808
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Schistosoma mansoni hypothetical protein 0.0301 0.3648 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0116 0.0295
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0151
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0076 0.01
Plasmodium falciparum importin beta, putative 0.0028 0.015 0.2001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0096
Brugia malayi hypothetical protein 0.0026 0.0116 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0818 0.1205
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.0033
Echinococcus multilocularis importin subunit beta 1 0.0028 0.015 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0532 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0182 0.2121 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.024 0.0186
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0818 0.1205
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0116 0.1279

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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