Detailed information for compound 842079

Basic information

Technical information
  • TDR Targets ID: 842079
  • Name: 5-chloro-2-methoxy-N-propan-2-ylbenzamide
  • MW: 227.687 | Formula: C11H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 2.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)NC(C)C)Cl
  • InChi: 1S/C11H14ClNO2/c1-7(2)13-11(14)9-6-8(12)4-5-10(9)15-3/h4-7H,1-3H3,(H,13,14)
  • InChiKey: XNRMIULTBWTSOE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-chloro-N-isopropyl-2-methoxy-benzamide
  • 5-chloro-N-isopropyl-2-methoxybenzamide
  • 5-chloro-2-methoxy-N-propan-2-yl-benzamide
  • ST043639
  • ZINC00030533
  • AE-641/11702997
  • MLS000680340
  • SMR000268642
  • BIM-0018636.P001
  • CBMicro_018765

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0035 0.024 0.0375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0457 0.1118
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0373 0.4571 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0076 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1263 0.5848
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0457 0.0404
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.0057
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0076 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0417 0.0571
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1834 0.2808
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.008 0.0818 0.128
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1263 0.5848
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0373 0.4571 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0076 0.0118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Leishmania major hypothetical protein, conserved 0.0022 0.0076 0.01
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0182 0.2121 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0076 0.01
Echinococcus granulosus snurportin 1 0.0301 0.3648 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0076 0.0057
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0417 0.0652
Echinococcus granulosus tar DNA binding protein 0.0062 0.0587 0.148
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0182 0.2121 0.2077
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0076 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1292 0.1952
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Loa Loa (eye worm) hypothetical protein 0.0089 0.0932 0.1385
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.0033
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.1205
Loa Loa (eye worm) hypothetical protein 0.0058 0.0532 0.0753
Loa Loa (eye worm) hypothetical protein 0.0033 0.0218 0.0257
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Brugia malayi MH2 domain containing protein 0.0117 0.1292 0.2022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1834 0.2808
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.024 0.0186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0076 0.0432
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0076 0.0057
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0076 0.0021
Schistosoma mansoni hypothetical protein 0.0171 0.1988 0.5379
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.024 0.0515
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0532 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0124 0.1378 0.2088
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0115 0.1263 0.1907
Schistosoma mansoni eyes absent homolog 0.0089 0.0932 0.2442
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0515 0.6392 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0457 0.1118
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0022 0.0076 0.0046
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.008 0.0818 0.0768
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0373 0.4571 0.7152
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0116 0.1279
Onchocerca volvulus 0.0373 0.4571 1
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0182 0.2121 0.575
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0115 0.1263 0.5848
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Plasmodium vivax importin-beta 2, putative 0.0028 0.015 0.2001
Schistosoma mansoni hypothetical protein 0.0301 0.3648 1
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0258 0.3097 1
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0115 0.1263 0.1907
Echinococcus multilocularis importin subunit beta 1 0.0028 0.015 0.0096
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1834 0.2808
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0116 0.1279
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0076 0.0057
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0076 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Leishmania major hypothetical protein, conserved 0.0026 0.0116 0.0295
Plasmodium falciparum GAF domain-related protein, putative 0.0058 0.0532 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0076 0.0432
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0076 0.0057
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0515 0.6392 1
Giardia lamblia Hypothetical protein 0.0022 0.0076 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0417 0.0571
Mycobacterium leprae conserved hypothetical protein 0.0058 0.0532 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0116 0.0343
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0076 0.0432
Schistosoma mansoni hypothetical protein 0.0033 0.0218 0.0454
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0182 0.2121 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0373 0.4571 0.7127
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Leishmania major hypothetical protein, conserved 0.0022 0.0076 0.01
Entamoeba histolytica hypothetical protein 0.0023 0.0082 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0818 0.1205
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0076 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0076 0.0033
Brugia malayi RNA, U transporter 1 0.008 0.0817 0.1278
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3648 0.567
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Leishmania major importin beta-1 subunit, putative 0.0023 0.0082 0.0131
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0182 0.2121 1
Brugia malayi RNA binding protein 0.0062 0.0587 0.0918
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0587 0.0839
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0076 0.0118
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0116 0.0295
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0082 0.0131
Brugia malayi Importin beta-1 subunit 0.0028 0.015 0.0235
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0417 0.0652
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0076 0.0432
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0033
Schistosoma mansoni hypothetical protein 0.0171 0.1988 0.5379
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.008 0.0818 0.128
Echinococcus multilocularis geminin 0.0171 0.1988 0.1943
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Entamoeba histolytica hypothetical protein 0.0035 0.024 0.041
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0116 0.0295
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0818 0.1205
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0076 0.01
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.008 0.0818 0.2125
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.024 0.0515
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0218 0.0341
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0076 0.01
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0124 0.1378 0.6404
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0076 0.01
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0182 0.2121 0.326
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0033
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0373 0.4571 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0457 0.1118
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0082 0.0043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0096
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0182 0.2121 0.575
Brugia malayi TAR-binding protein 0.0062 0.0587 0.0918
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0076 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0457 0.0634
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0373 0.4571 0.7127
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.0432
Giardia lamblia hypothetical protein 0.0022 0.0076 0.0046
Plasmodium falciparum importin beta, putative 0.0028 0.015 0.2001
Toxoplasma gondii hypothetical protein 0.0058 0.0532 0.268
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Schistosoma mansoni hypothetical protein 0.0035 0.024 0.0515
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0116 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0587 0.0839
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0076 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0082 0.0043
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0182 0.2121 1
Echinococcus multilocularis snurportin 1 0.0301 0.3648 0.3613
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0587 0.0535
Brugia malayi hypothetical protein 0.0089 0.0932 0.1459
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0818 0.1205
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0082 0.0043
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0076 0.0021
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0373 0.4571 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0182 0.2121 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Brugia malayi hypothetical protein 0.0026 0.0116 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0587 0.0918
Echinococcus granulosus importin subunit beta 1 0.0028 0.015 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.01
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0033
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.008 0.0818 0.2125
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0116 0.1279
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1292 0.1952
Leishmania major hypothetical protein, conserved 0.0115 0.1263 0.5848
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0055 0.0086
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0457 0.0715
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0457 0.1118
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0076 0.0118
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0373 0.4571 0.7127
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0373 0.4571 0.7127
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0076 0.01
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.015 0.0536
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0151
Loa Loa (eye worm) PDE1B protein 0.0022 0.0076 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0338 0.4121 0.6417
Loa Loa (eye worm) hypothetical protein 0.0089 0.0932 0.1385
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0076 0.01
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0457 0.1118
Toxoplasma gondii hypothetical protein 0.0058 0.0532 0.268
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.015 0.0462
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0076 0.0021
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0076 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.2121 0.326
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4355 0.6785
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Schistosoma mansoni importin beta-1 0.0028 0.015 0.0266
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.6392 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0076 0.01
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0076 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4355 0.6785
Loa Loa (eye worm) RNA binding protein 0.0062 0.0587 0.0839
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0076 0.01
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0587 0.148
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0124 0.1378 0.2088
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus granulosus geminin 0.0171 0.1988 0.5379
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0076 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0076 0.0116
Toxoplasma gondii hypothetical protein 0.0159 0.1834 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0182 0.2121 0.326
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0076 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0532 0.0753
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.015 0.0462
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0076 0.0118
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0076 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0457 0.0404
Toxoplasma gondii GAF domain-containing protein 0.0058 0.0532 0.268

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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