Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.5629 | 1 | 1 | |
Chlamydia trachomatis | replicative DNA helicase | 0.0644 | 0.089 | 0.5 |
Trichomonas vaginalis | pten, drome, putative | 0.0158 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.5629 | 1 | 1 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0158 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0158 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0158 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.1606 | 0.2648 | 0.2648 |
Loa Loa (eye worm) | twinkle helicase | 0.0184 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1606 | 0.2648 | 0.2648 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0158 | 0 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0158 | 0 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0158 | 0 | 0.5 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0644 | 0.089 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0644 | 0.089 | 0.5 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0158 | 0 | 0.5 |
Plasmodium vivax | multidrug resistance-associated protein 1, putative | 0.1225 | 0.1952 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0644 | 0.089 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0158 | 0 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0644 | 0.089 | 0.5 |
Schistosoma mansoni | Replicative DNA helicase | 0.0644 | 0.089 | 0.3361 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0158 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0644 | 0.089 | 0.5 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0158 | 0 | 0.5 |
Onchocerca volvulus | 0.5629 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1606 | 0.2648 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1606 | 0.2648 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1606 | 0.2648 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.