Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0621 | 0.0621 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0027 | 0.0621 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0938 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0861 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0027 | 0.0621 | 0.5 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0027 | 0.0621 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0027 | 0.0621 | 1 |
Brugia malayi | cDNA sequence BC016226 | 0.0027 | 0.0621 | 0.6623 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0107 | 0.1145 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0.0621 | 1 |
Schistosoma mansoni | fad oxidoreductase | 0.0027 | 0.0621 | 0.0621 |
Mycobacterium ulcerans | glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0621 | 0.036 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0027 | 0.0621 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0271 | 0.0271 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0027 | 0.0621 | 0.5 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0621 | 0.0621 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0302 | 0.9147 | 1 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0027 | 0.0621 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0938 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0027 | 0.0621 | 0.036 |
Schistosoma mansoni | d-amino acid oxidase | 0.033 | 1 | 1 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0027 | 0.0621 | 0.5 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0621 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0621 | 0.5 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0027 | 0.0621 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0784 | 0.0784 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0107 | 0.1145 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0027 | 0.0621 | 1 |
Mycobacterium ulcerans | thiamine biosynthesis oxidoreductase ThiO | 0.0027 | 0.0621 | 0.036 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0107 | 0.0107 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0107 | 0.1145 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0027 | 0.0621 | 0.6623 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0107 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0621 | 0.0621 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0938 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.033 | 1 | 1 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0.0621 | 0.5 |
Schistosoma mansoni | NAD dehydrogenase | 0.0027 | 0.0621 | 0.0621 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0027 | 0.0621 | 0.6623 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0027 | 0.0621 | 1 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0027 | 0.0621 | 0.5 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0027 | 0.0621 | 0.6623 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0621 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0271 | 0.2887 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0938 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0046 | 0.0046 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0027 | 0.0621 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0271 | 0.0271 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0027 | 0.0621 | 1 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0027 | 0.0621 | 0.6623 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.1046 | 0.1046 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.1046 | 0.1046 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0.0621 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0621 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0621 | 0.0621 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0861 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0621 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.033 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0107 | 0.0107 |
Brugia malayi | RE18450p | 0.0027 | 0.0621 | 0.6623 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0027 | 0.0621 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0107 | 0.1145 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0271 | 0.2887 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0027 | 0.0621 | 1 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0027 | 0.0621 | 1 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0027 | 0.0621 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0107 | 0.0107 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0621 | 1 |
Mycobacterium ulcerans | glycerol-3-phosphate dehydrogenase GlpD2 | 0.0027 | 0.0621 | 0.036 |
Schistosoma mansoni | fad oxidoreductase | 0.0027 | 0.0621 | 0.0621 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0271 | 0.0271 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0027 | 0.0621 | 0.0621 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0027 | 0.0621 | 0.6623 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0027 | 0.0621 | 0.6623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.