Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1175 | 0.1016 |
Toxoplasma gondii | DNA polymerase family B protein | 0.0026 | 0.0444 | 0.1328 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1175 | 0.1175 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0177 | 0.0177 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.0077 | 0.3339 | 0.3339 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0026 | 0.0444 | 0.1328 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0116 | 0.5486 | 0.8837 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0177 | 0.0285 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2091 | 0.1949 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0197 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1175 | 0.1175 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.1853 | 0.555 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1175 | 0.1016 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.1853 | 0.1853 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0063 | 0.2548 | 0.2548 |
Toxoplasma gondii | DNA polymerase | 0.0077 | 0.3339 | 1 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2091 | 0.1949 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 1 | 1 |
Brugia malayi | DNA polymerase family B containing protein | 0.0026 | 0.0444 | 0.0444 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0197 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Plasmodium vivax | DNA polymerase zeta catalytic subunit, putative | 0.0026 | 0.0444 | 0.1328 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1175 | 0.1016 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.0077 | 0.3339 | 0.3339 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.1853 | 0.1706 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0444 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1119 | 0.1119 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0116 | 0.5486 | 0.8837 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0177 | 0.0177 |
Echinococcus granulosus | DNA polymerase zeta catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.0077 | 0.3339 | 0.3339 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 1 | 1 |
Echinococcus granulosus | dna polymerase epsilon catalytic subunit a | 0.0026 | 0.0444 | 0.0444 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0177 | 0.0177 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0177 | 0.0177 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.0077 | 0.3339 | 0.3219 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0177 | 0.0177 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0197 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0177 | 0.053 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.1853 | 0.555 |
Giardia lamblia | DNA polymerase epsilon, catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0026 | 0.0444 | 0.0444 |
Plasmodium vivax | DNA polymerase epsilon, catalytic subunit a, putative | 0.0026 | 0.0444 | 0.1328 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0197 | 1 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0197 | 1 | 1 |
Trypanosoma brucei | DNA polymerase epsilon catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0129 | 0.6208 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0177 | 0.053 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0177 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0116 | 0.5486 | 0.8837 |
Leishmania major | trypanothione reductase | 0.0051 | 0.1853 | 0.1853 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1175 | 0.1175 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0197 | 1 | 1 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.0077 | 0.3339 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0129 | 0.6208 | 1 |
Trypanosoma brucei | DNA polymerase zeta catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.0077 | 0.3339 | 0.3339 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.1853 | 0.2985 |
Mycobacterium tuberculosis | Probable reductase | 0.0116 | 0.5486 | 0.8837 |
Echinococcus multilocularis | DNA polymerase zeta catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.1853 | 0.1853 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.0077 | 0.3339 | 0.3219 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0197 | 1 | 1 |
Brugia malayi | DNA polymerase delta catalytic subunit | 0.0077 | 0.3339 | 0.3339 |
Echinococcus multilocularis | dna polymerase epsilon catalytic subunit a | 0.0026 | 0.0444 | 0.0444 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0197 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0177 | 0.0177 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0197 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0177 | 0.0177 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0197 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0197 | 1 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.1853 | 0.1706 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0177 | 0.0177 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0177 | 0.053 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0026 | 0.0444 | 0.1328 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2091 | 0.2091 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0129 | 0.6208 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0197 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0197 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0116 | 0.5486 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1119 | 0.0959 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2091 | 0.2091 |
Leishmania major | DNA polymerase epsilon catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Echinococcus multilocularis | geminin | 0.0182 | 0.918 | 0.918 |
Giardia lamblia | DNA polymerase delta, catalytic subunit | 0.0077 | 0.3339 | 0.3339 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.1853 | 0.555 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.0077 | 0.3339 | 0.3339 |
Echinococcus granulosus | geminin | 0.0182 | 0.918 | 0.918 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.918 | 0.918 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.1853 | 0.1853 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0197 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0129 | 0.6208 | 1 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0077 | 0.3339 | 0.3339 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1175 | 0.1016 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.0077 | 0.3339 | 0.3339 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.918 | 0.918 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.1853 | 0.555 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.1853 | 0.1853 |
Brugia malayi | glutathione reductase | 0.0051 | 0.1853 | 0.1853 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.1853 | 0.1853 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0177 | 0.0177 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.1853 | 0.555 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0177 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0197 | 1 | 1 |
Onchocerca volvulus | DNA polymerase delta catalytic subunit homolog | 0.0077 | 0.3339 | 1 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0026 | 0.0444 | 0.0444 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0177 | 0.0177 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1119 | 0.1119 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1175 | 0.1175 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0177 | 1 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.0026 | 0.0444 | 0.0444 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1175 | 0.1175 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.0077 | 0.3339 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0116 | 0.5486 | 0.8837 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0177 | 0.0177 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0026 | 0.0444 | 0.0444 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0177 | 0.0177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cured/treated (functional) | = 0 | Antimalarial activity was determined by Blood schizonticidal activity in mouse infected with Plasmodium berghei(K-173 strain) at 5 (mg/kg x5) subcutaneous dosage; Cured/treated = 0/6 on day 7 | ChEMBL. | 7783124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.