Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0122 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3423 | 0.4963 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3423 | 0.3423 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0122 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0122 | 0.0177 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3423 | 0.3423 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3423 | 0.3423 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1726 | 0.1726 |
Echinococcus multilocularis | geminin | 0.0173 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1726 | 0.2503 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0122 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0122 | 0.0177 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3423 | 0.4963 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3423 | 0.4963 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0122 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0122 | 0.0122 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1726 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0122 | 0.0122 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1726 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0122 | 0.0177 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1726 | 0.1726 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3423 | 0.4963 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0122 | 0.0122 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.6896 | 1 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1726 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0122 | 0.0177 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0122 | 0.0122 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0122 | 0.0122 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3423 | 0.3423 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0122 | 0.0177 |
Onchocerca volvulus | 0.001 | 0.0122 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0122 | 0.0122 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0122 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0122 | 0.0122 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3423 | 0.3423 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1726 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0122 | 0.0177 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.6896 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1726 | 0.1726 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.6896 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3423 | 0.3423 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3423 | 0.4963 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3423 | 0.4963 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0122 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0122 | 0.0177 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0122 | 0.0122 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0122 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0122 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0122 | 0.0177 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0122 | 0.0122 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0122 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1726 | 0.1726 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0122 | 0.0122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3423 | 0.3423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.