Detailed information for compound 863490

Basic information

Technical information
  • TDR Targets ID: 863490
  • Name: N-[(2-bromophenyl)methyl]-5-[(4-bromophenyl)s ulfinylmethyl]furan-2-carboxamide
  • MW: 497.2 | Formula: C19H15Br2NO3S
  • H donors: 1 H acceptors: 2 LogP: 4.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)S(=O)Cc1ccc(o1)C(=O)NCc1ccccc1Br
  • InChi: 1S/C19H15Br2NO3S/c20-14-5-8-16(9-6-14)26(24)12-15-7-10-18(25-15)19(23)22-11-13-3-1-2-4-17(13)21/h1-10H,11-12H2,(H,22,23)
  • InChiKey: NBEHKRCAEYPADQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-bromophenyl)methyl]-5-[(4-bromophenyl)sulfinylmethyl]-2-furancarboxamide
  • N-(2-bromobenzyl)-5-[(4-bromophenyl)sulfinylmethyl]-2-furamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.1236 0.167
Brugia malayi CHE-14 protein 0.0042 0.1236 0.167
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.3859 0.541
Plasmodium falciparum dynamin-like protein 0.0161 0.6819 1
Trichomonas vaginalis dynamin, putative 0.0161 0.6819 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.3859 0.5214
Entamoeba histolytica dynamin-1-like protein, putative 0.0049 0.1548 0.1826
Loa Loa (eye worm) hypothetical protein 0.0174 0.7401 1
Schistosoma mansoni patched 1 0.0042 0.1236 0.167
Brugia malayi Muscleblind-like protein 0.0147 0.616 0.8324
Echinococcus granulosus dynamin 0.0161 0.6819 0.9214
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.5831 0.7879
Trypanosoma cruzi dynamin-1-like protein 0.0161 0.6819 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.037 0.3277
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0091 0.5
Brugia malayi Dynamin 0.0174 0.7401 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.037 0.3277
Echinococcus granulosus Protein patched homolog 1 0.0042 0.1236 0.167
Echinococcus multilocularis protein patched 0.0042 0.1236 0.167
Loa Loa (eye worm) hypothetical protein 0.0042 0.1236 0.167
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1591 0.2149
Mycobacterium ulcerans hypothetical protein 0.0036 0.0944 1
Schistosoma mansoni hypothetical protein 0.0041 0.1165 0.1574
Loa Loa (eye worm) hypothetical protein 0.0024 0.037 0.05
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0091 0.0045
Loa Loa (eye worm) beta-lactamase 0.0036 0.0944 0.1276
Brugia malayi AMP-binding enzyme family protein 0.0024 0.037 0.05
Toxoplasma gondii dynamin-related protein DRPA 0.0161 0.6819 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.037 0.05
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.037 0.0326
Giardia lamblia Dynamin 0.0161 0.6819 0.5
Brugia malayi beta-lactamase 0.0036 0.0944 0.1276
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.5831 0.7879
Loa Loa (eye worm) hypothetical protein 0.0036 0.0944 0.1276
Mycobacterium tuberculosis Conserved protein 0.0036 0.0944 0.0903
Echinococcus granulosus dynamin 1 0.0174 0.7401 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.616 0.8324
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.393 0.531
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0944 0.0903
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.1236 0.167
Mycobacterium leprae Probable lipase LipE 0.0036 0.0944 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.1514 0.2046
Onchocerca volvulus 0.0036 0.0944 1
Plasmodium falciparum dynamin-like protein 0.0161 0.6819 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0944 0.0903
Leishmania major GTP-binding protein, putative 0.0161 0.6819 1
Entamoeba histolytica dynamin-1-like protein, putative 0.0161 0.6819 1
Schistosoma mansoni dynamin 0.0174 0.7401 1
Toxoplasma gondii dynamin gtpase 0.0106 0.4242 0.5613
Schistosoma mansoni dynamin 0.0174 0.7401 1
Trichomonas vaginalis dynamin, putative 0.0161 0.6819 1
Brugia malayi Dynamin 0.0174 0.7401 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.1236 0.167
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.037 0.3277
Loa Loa (eye worm) hypothetical protein 0.0024 0.037 0.05
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0944 0.1276
Trichomonas vaginalis dynamin, putative 0.0161 0.6819 1
Toxoplasma gondii dynamin-related protein DRPB 0.0161 0.6819 1
Echinococcus multilocularis expressed conserved protein 0.0092 0.358 0.4838
Echinococcus multilocularis dynamin 1 protein 0.0161 0.6819 0.9214
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0944 0.0903
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.037 0.3277
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.037 0.0326
Trichomonas vaginalis dynamin, putative 0.0161 0.6819 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0944 0.0903
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0944 1
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.3859 0.5214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0122
Brugia malayi Dynamin central region family protein 0.0161 0.6819 0.9214
Echinococcus granulosus dynamin 1 protein 0.0161 0.6819 0.9214
Plasmodium vivax dynamin protein, putative 0.0161 0.6819 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.037 0.05
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0944 0.1276
Schistosoma mansoni dynamin 0.0161 0.6819 0.9214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0024 0.037 0.05
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0944 0.1276
Echinococcus multilocularis muscleblind protein 0.0147 0.616 0.8324
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.037 0.3277
Loa Loa (eye worm) hypothetical protein 0.0052 0.1679 0.2269
Onchocerca volvulus 0.0036 0.0944 1
Entamoeba histolytica dynamin-like protein 0.0161 0.6819 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0944 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0854 0.1154
Mycobacterium tuberculosis Conserved protein 0.0036 0.0944 0.0903
Trichomonas vaginalis dynamin, putative 0.0161 0.6819 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.037 0.3277
Brugia malayi beta-lactamase family protein 0.0036 0.0944 0.1276
Echinococcus multilocularis muscleblind protein 1 0.0147 0.616 0.8324
Loa Loa (eye worm) hypothetical protein 0.0034 0.0854 0.1154
Trypanosoma brucei dynamin-1-like protein 0.0161 0.6819 1
Echinococcus multilocularis dynamin 0.0161 0.6819 0.9214
Loa Loa (eye worm) DRP-1 protein 0.0161 0.6819 0.9214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0944 0.1276
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0944 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.037 0.3277
Mycobacterium ulcerans lipase LipD 0.0036 0.0944 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0944 0.0903
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0161 0.6819 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0944 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1236 0.0496
Brugia malayi beta-lactamase family protein 0.0036 0.0944 0.1276
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0944 0.1276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1591 0.2149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0944 0.1276
Echinococcus granulosus muscleblind protein 0.0147 0.616 0.8324
Schistosoma mansoni hypothetical protein 0.0041 0.1165 0.1574
Mycobacterium ulcerans hypothetical protein 0.0024 0.037 0.3277
Loa Loa (eye worm) hypothetical protein 0.0036 0.0944 0.1276
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0944 0.0903
Loa Loa (eye worm) hypothetical protein 0.005 0.1591 0.2149
Schistosoma mansoni hypothetical protein 0.0041 0.1165 0.1574
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0122
Trichomonas vaginalis mgm1, putative 0.0161 0.6819 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.3859 0.5214
Schistosoma mansoni hypothetical protein 0.0034 0.0854 0.1154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0944 0.1276
Trichomonas vaginalis dynamin, putative 0.0161 0.6819 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0944 0.1276
Plasmodium vivax dynamin-like protein, putative 0.0161 0.6819 1
Echinococcus multilocularis dynamin 1 0.0174 0.7401 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0944 0.1276
Echinococcus granulosus expressed conserved protein 0.0092 0.358 0.4838
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0944 1
Trypanosoma brucei dynamin-1-like protein 0.0161 0.6819 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0944 0.1276
Loa Loa (eye worm) hypothetical protein 0.0098 0.3859 0.5214
Schistosoma mansoni hypothetical protein 0.0041 0.1165 0.1574
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1591 0.2149
Leishmania major hypothetical protein, conserved 0.0036 0.0944 0.089
Loa Loa (eye worm) hypothetical protein 0.0147 0.616 0.8324
Onchocerca volvulus 0.0036 0.0944 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0944 0.1269
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0944 0.0903

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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