Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acyl-CoA desaturase | 0.036 | 0.8855 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0382 | 1 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.036 | 0.8855 | 0.5 |
Onchocerca volvulus | 0.0382 | 0.9965 | 1 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0382 | 1 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.036 | 0.8855 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.111 | 0.1254 |
Loa Loa (eye worm) | FAT-3 protein | 0.0212 | 0.111 | 0.1254 |
Brugia malayi | acyl-CoA desaturase | 0.036 | 0.8855 | 1 |
Onchocerca volvulus | 0.0382 | 0.9965 | 1 | |
Schistosoma mansoni | fatty acid desaturase | 0.0213 | 0.1145 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0382 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.