TDR Targets

Basic information

Technical information

TDR Targets ID: 867621
Name: 2-fluoro-5-morpholin-4-ylsulfonylbenzamide
MW: 288.295 | Formula: C11H13FN2O4S
H donors: 1 H acceptors: 3 LogP: -0.33 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)c1cc(ccc1F)S(=O)(=O)N1CCOCC1
InChi: 1S/C11H13FN2O4S/c12-10-2-1-8(7-9(10)11(13)15)19(16,17)14-3-5-18-6-4-14/h1-2,7H,3-6H2,(H2,13,15)
InChiKey: NXZUQVUIUJAOCC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-fluoro-5-morpholinosulfonyl-benzamide
2-fluoro-5-morpholinosulfonylbenzamide
2-fluoro-5-morpholin-4-ylsulfonyl-benzamide
ZINC00260564
ChemDiv3_013350
Oprea1_331035

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0235	0.5538	0.5538
Trypanosoma cruzi	polo-like protein kinase, putative	0.0072	0.1546	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0016	0.0175	0.0881
Brugia malayi	RNA, U transporter 1	0.0063	0.1312	0.1312
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0071	0.1505	1
Brugia malayi	Carboxylesterase family protein	0.0071	0.1505	0.1505
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0016	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0072	0.1546	0.1546
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0071	0.1505	0.1505
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0016	0.0175	0.0175
Echinococcus multilocularis	acetylcholinesterase	0.0418	1	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0011	0.0043	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0418	1	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0071	0.1505	0.1505
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0016	0.0175	0.0881
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0071	0.1505	0.1505
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0011	0.0043	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.048	0.048
Plasmodium falciparum	importin beta, putative	0.0022	0.0318	1
Echinococcus granulosus	BC026374 protein S09 family	0.0071	0.1505	0.1505
Leishmania major	importin beta-1 subunit, putative	0.0018	0.0216	0.115
Trichomonas vaginalis	spcc417.12 protein, putative	0.0071	0.1505	0.9731
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0022	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0235	0.5538	0.5538
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1505	0.1505
Echinococcus multilocularis	importin subunit beta 1	0.0022	0.0318	0.0318
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0071	0.1505	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0029	0.048	0.048
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0016	0.0175	0.0175
Schistosoma mansoni	BC026374 protein (S09 family)	0.0071	0.1505	0.1505
Entamoeba histolytica	Ran family GTPase	0.0016	0.0175	0.0881
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0018	0.0216	0.115
Brugia malayi	Carboxylesterase family protein	0.0071	0.1505	0.1505
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0072	0.1546	1
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0022	0.0318	0.1829
Trichomonas vaginalis	ran, putative	0.0016	0.0175	0.0881
Trichomonas vaginalis	CAMK family protein kinase	0.0036	0.0653	0.4061
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0016	0.0175	0.0175
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0016	0.0175	0.4817
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0318	0.0318
Trypanosoma brucei	polo-like protein kinase	0.0072	0.1546	1
Echinococcus granulosus	neuroligin	0.0071	0.1505	0.1505
Schistosoma mansoni	kinase	0.0037	0.0676	0.0676
Echinococcus granulosus	acetylcholinesterase	0.0418	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0018	0.0216	0.115
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1505	0.1505
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0018	0.0216	0.115
Echinococcus granulosus	snurportin 1	0.0235	0.5538	0.5538
Schistosoma mansoni	gliotactin	0.0071	0.1505	0.1505
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.1546	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0418	1	1
Schistosoma mansoni	ap endonuclease	0.0011	0.0043	0.0043
Echinococcus granulosus	carboxylesterase 5A	0.0418	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Brugia malayi	Carboxylesterase family protein	0.0071	0.1505	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Echinococcus multilocularis	snurportin 1	0.0235	0.5538	0.5538
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Brugia malayi	latrophilin 2 splice variant baaae	0.002	0.0258	0.0258
Echinococcus multilocularis	neuroligin	0.0071	0.1505	0.1505
Echinococcus multilocularis	carboxylesterase 5A	0.0418	1	1
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1505	0.1505
Trichomonas vaginalis	CAMK family protein kinase	0.0036	0.0653	0.4061
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0016	0.0175	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Schistosoma mansoni	ap endonuclease	0.0011	0.0043	0.0043
Brugia malayi	exodeoxyribonuclease III family protein	0.0011	0.0043	0.0043
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0029	0.048	0.048
Brugia malayi	Carboxylesterase family protein	0.0071	0.1505	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Loa Loa (eye worm)	hypothetical protein	0.002	0.0258	0.0258
Giardia lamblia	Kinase, PLK	0.0072	0.1546	1
Brugia malayi	Carboxylesterase family protein	0.0418	1	1
Trichomonas vaginalis	importin beta-1, putative	0.0018	0.0216	0.115
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0071	0.1505	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0071	0.1505	0.1505
Trypanosoma brucei	importin beta-1 subunit, putative	0.0022	0.0318	0.1829
Leishmania major	GTP-binding protein, putative	0.0016	0.0175	0.0881
Trypanosoma cruzi	polo-like protein kinase, putative	0.0072	0.1546	1
Brugia malayi	Importin beta-1 subunit	0.0022	0.0318	0.0318
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0072	0.1546	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0016	0.0175	0.4817
Brugia malayi	hypothetical protein	0.0071	0.1505	0.1505
Echinococcus granulosus	importin subunit beta 1	0.0022	0.0318	0.0318
Echinococcus multilocularis	acetylcholinesterase	0.0418	1	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0072	0.1546	0.1546
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0071	0.1505	0.9731
Mycobacterium ulcerans	carboxylesterase, LipT	0.0071	0.1505	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1505	0.1505
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0016	0.0175	0.0881
Trichomonas vaginalis	CAMK family protein kinase	0.0072	0.1546	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1505	0.1505
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0011	0.0043	0.0043
Schistosoma mansoni	ran	0.0016	0.0175	0.0175
Loa Loa (eye worm)	carboxylesterase	0.0418	1	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0071	0.1505	0.1505
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0072	0.1546	0.1546
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0029	0.048	0.048
Loa Loa (eye worm)	acetylcholinesterase 1	0.0418	1	1
Echinococcus granulosus	acetylcholinesterase	0.0418	1	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0071	0.1505	0.1505
Schistosoma mansoni	acetylcholinesterase	0.0071	0.1505	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0418	1	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0072	0.1546	1
Schistosoma mansoni	hypothetical protein	0.002	0.0258	0.0258
Plasmodium vivax	importin-beta 2, putative	0.0022	0.0318	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0011	0.0043	0.0043
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0016	0.0175	0.4817
Schistosoma mansoni	importin beta-1	0.0022	0.0318	0.0318
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0011	0.0043	0.0043
Entamoeba histolytica	hypothetical protein	0.0018	0.0216	0.115
Schistosoma mansoni	ran	0.0016	0.0175	0.0175
Brugia malayi	serine/threonine-protein kinase plk-2	0.0072	0.1546	0.1546
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1505	0.1505

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867621