Detailed information for compound 869506

Basic information

Technical information
  • TDR Targets ID: 869506
  • Name: 2-(4-methoxyphenyl)-N-(pyridin-2-ylmethyl)imi dazo[2,1-b][1,3]benzothiazole-6-carboxamide
  • MW: 414.48 | Formula: C23H18N4O2S
  • H donors: 1 H acceptors: 3 LogP: 4.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cn2c(n1)sc1c2ccc(c1)C(=O)NCc1ccccn1
  • InChi: 1S/C23H18N4O2S/c1-29-18-8-5-15(6-9-18)19-14-27-20-10-7-16(12-21(20)30-23(27)26-19)22(28)25-13-17-4-2-3-11-24-17/h2-12,14H,13H2,1H3,(H,25,28)
  • InChiKey: AWMPTSNQDNBWMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-N-(2-pyridylmethyl)imidazo[2,1-b][1,3]benzothiazole-6-carboxamide
  • 2-(4-methoxyphenyl)-N-(2-pyridylmethyl)-6-imidazo[2,1-b][1,3]benzothiazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutamate receptor 2 0.0213 0.3293 0.3596
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0346 0.0835
Onchocerca volvulus 0.0062 0.0363 0.0415
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0085 0.0803 0.0803
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0958 0.1046
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0363 0.0363
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0558 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0256 0.4137 0.4137
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0213 0.3293 0.3293
Echinococcus granulosus tar DNA binding protein 0.0061 0.0346 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0346 0.0835
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0958 0.1046
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0318 0.0318
Loa Loa (eye worm) glutamate receptor 1 0.0514 0.9156 1
Schistosoma mansoni glutamate receptor kainate 0.0213 0.3293 0.7959
Schistosoma mansoni ATP-binding cassette transporter 0.0213 0.3293 0.7959
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0072 0.0546 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0958 0.0958
Onchocerca volvulus 0.0493 0.8733 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0386 0.6666 0.6666
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.3795 0.4145
Loa Loa (eye worm) hypothetical protein 0.0302 0.5019 0.5482
Brugia malayi Glutamate receptor 2 precursor 0.0514 0.9156 1
Chlamydia trachomatis glutamine binding protein 0.0072 0.0546 0.5
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0085 0.0803 0.0803
Trichomonas vaginalis set domain proteins, putative 0.0493 0.8733 0.5
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0558 1 1
Plasmodium vivax SET domain protein, putative 0.0062 0.0363 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0213 0.3293 0.7959
Loa Loa (eye worm) RNA binding protein 0.0061 0.0346 0.0377
Echinococcus multilocularis NMDA receptor 0.0085 0.0803 0.0803
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0363 0.0363
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0958 0.0958
Schistosoma mansoni glutamate receptor NMDA 0.0256 0.4137 1
Brugia malayi Glutamate receptor 1 precursor 0.0514 0.9156 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0958 0.2315
Echinococcus multilocularis glutamate receptor 4 0.0302 0.5019 0.5019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0958 0.2315
Entamoeba histolytica hypothetical protein 0.0043 0 0.5
Echinococcus multilocularis glutamate receptor 2 0.0473 0.8353 0.8353
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0256 0.4137 0.4137
Trypanosoma cruzi extracellular receptor, putative 0.0043 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0302 0.5019 0.5482
Schistosoma mansoni glutamate receptor kainate 0.0213 0.3293 0.7959
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0363 0.5
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0346 0.0835
Echinococcus granulosus glutamate receptor 1 0.0302 0.5019 0.5019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0958 0.0958
Brugia malayi RNA binding protein 0.0061 0.0346 0.0377
Echinococcus multilocularis glutamate receptor 2 0.0558 1 1
Schistosoma mansoni glutamate receptor kainate 0.0213 0.3293 0.7959
Schistosoma mansoni hypothetical protein 0.0085 0.0803 0.194
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0346 0.0377
Loa Loa (eye worm) hypothetical protein 0.0302 0.5019 0.5482
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0256 0.4137 0.4137
Echinococcus multilocularis nmda type glutamate receptor 0.0156 0.2193 0.2193
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0256 0.4137 0.4137
Echinococcus granulosus glutamate NMDA receptor subunit 0.0213 0.3293 0.3293
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0085 0.0803 0.0803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0363 0.0877
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0346 0.0835
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0072 0.0546 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0958 0.2315
Echinococcus granulosus glutamate receptor 4 0.0302 0.5019 0.5019
Echinococcus granulosus glutamate receptor 2 0.0473 0.8353 0.8353
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0958 0.0958
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0363 0.0877
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0256 0.4137 0.4137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0363 0.0877
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.7571 0.8269
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0085 0.0803 0.0803
Echinococcus granulosus nmda type glutamate receptor 0.0156 0.2193 0.2193
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0072 0.0546 0.5
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0072 0.0546 0.5
Brugia malayi TAR-binding protein 0.0061 0.0346 0.0377
Echinococcus multilocularis glutamate receptor 2 0.0514 0.9156 0.9156
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0346 0.0835
Brugia malayi Pre-SET motif family protein 0.0433 0.7571 0.8269
Leishmania major extracellular receptor, putative 0.0043 0 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0346 0.0377
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0072 0.0546 0.5
Schistosoma mansoni glutamate receptor AMPA 0.0213 0.3293 0.7959
Schistosoma mansoni glutamate receptor AMPA 0.0213 0.3293 0.7959
Brugia malayi Pre-SET motif family protein 0.0062 0.0363 0.0396
Loa Loa (eye worm) hypothetical protein 0.0062 0.0363 0.0396
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0386 0.6666 0.6666
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0256 0.4137 0.4137
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0156 0.2193 0.2193
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0363 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0363 0.0877
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0085 0.0803 0.0803
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0346 0.0377
Brugia malayi follicle stimulating hormone receptor 0.0239 0.3795 0.4145

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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