TDR Targets

Basic information

Technical information

TDR Targets ID: 871942
Name: N-(2,6-dimethylphenyl)-6-methyl-2-thiophen-2- ylimidazo[3,2-a]pyridin-3-amine
MW: 333.45 | Formula: C20H19N3S
H donors: 1 H acceptors: 1 LogP: 6.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc2n(c1)c(Nc1c(C)cccc1C)c(n2)c1cccs1
InChi: 1S/C20H19N3S/c1-13-9-10-17-21-19(16-8-5-11-24-16)20(23(17)12-13)22-18-14(2)6-4-7-15(18)3/h4-12,22H,1-3H3
InChiKey: RWSLTXBMOOYZMS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,6-dimethylphenyl)-6-methyl-2-(2-thienyl)imidazo[3,2-a]pyridin-3-amine
N-(2,6-dimethylphenyl)-6-methyl-2-(2-thienyl)-3-imidazo[3,2-a]pyridinamine
(2,6-dimethylphenyl)-[6-methyl-2-(2-thienyl)imidazo[3,2-a]pyridin-3-yl]amine
N-(2,6-dimethylphenyl)-6-methyl-2-thiophen-2-yl-imidazo[3,2-a]pyridin-3-amine
STK228131
C239-0644
NCGC00106159-01
ZINC00426794

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Leishmania major	eukaryotic initiation factor 4a, putative	0.01	0.1806	0.6293
Loa Loa (eye worm)	hypothetical protein	0.0081	0.094	0.1498
Echinococcus multilocularis	cysteine protease	0.0118	0.2675	0.414
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.01	0.1806	0.6587
Schistosoma mansoni	cathepsin F (C01 family)	0.0118	0.2675	0.5207
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Entamoeba histolytica	cysteine proteinase, putative	0.0081	0.094	0.3182
Schistosoma mansoni	cathepsin F (C01 family)	0.0081	0.094	0.1657
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.6276	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.094	0.3182
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.6276	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.6276	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0081	0.094	0.1788
Brugia malayi	Cathepsin L-like precursor	0.0118	0.2675	0.4262
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.6276	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0162	0.4658	0.9266
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.01	0.1806	0.4994
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Entamoeba histolytica	cysteine proteinase, putative	0.0118	0.2675	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0118	0.2675	0.562
Loa Loa (eye worm)	fibroinase	0.0118	0.2675	0.4262
Brugia malayi	Cathepsin L-like precursor	0.0118	0.2675	0.4262
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Echinococcus granulosus	cathepsin l1	0.0081	0.094	0.1317
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.094	0.1498
Brugia malayi	Papain family cysteine protease containing protein	0.0063	0.013	0.0207
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.01	0.1806	0.6587
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0118	0.2675	0.414
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Leishmania major	eukaryotic initiation factor 4a, putative	0.01	0.1806	0.6293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Onchocerca volvulus	Cathepsin L homolog	0.0118	0.2675	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Brugia malayi	Cathepsin L-like precursor	0.0118	0.2675	0.4262
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.01	0.1806	0.3702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Echinococcus multilocularis	cysteine protease	0.0118	0.2675	0.414
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0118	0.2675	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0118	0.2675	0.414
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.01	0.1806	0.2727
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.01	0.1806	0.343
Echinococcus granulosus	cathepsin l1	0.0118	0.2675	0.414
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Plasmodium falciparum	eukaryotic initiation factor 4A	0.01	0.1806	0.6587
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0118	0.2675	0.4262
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.01	0.1806	0.6587
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Loa Loa (eye worm)	hypothetical protein	0.0118	0.2675	0.4262
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.01	0.1806	0.343
Treponema pallidum	ATP-dependent RNA helicase	0.01	0.1806	0.5
Onchocerca volvulus		0.0118	0.2675	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0118	0.2675	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0162	0.4658	0.9266
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0118	0.2675	0.414
Brugia malayi	Papain family cysteine protease containing protein	0.0118	0.2675	0.4262
Onchocerca volvulus		0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0118	0.2675	0.4262
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Plasmodium vivax	RNA helicase-1, putative	0.01	0.1806	0.6587
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0162	0.4658	0.9266
Onchocerca volvulus		0.0118	0.2675	1
Brugia malayi	Papain family cysteine protease containing protein	0.0063	0.013	0.0207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0162	0.4658	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.6276	1
Echinococcus granulosus	cathepsin b	0.0162	0.4658	0.7367
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.01	0.1806	0.6587
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.01	0.1806	0.6587
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0067	0.0332	0.0794
Schistosoma mansoni	alpha-glucosidase	0.0169	0.5017	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.01	0.1806	0.2727
Brugia malayi	Cathepsin L-like precursor	0.0081	0.094	0.1498
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0118	0.2675	0.414
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Loa Loa (eye worm)	ctsf protein	0.0118	0.2675	0.4262
Schistosoma mansoni	alpha-glucosidase	0.0169	0.5017	1
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Plasmodium vivax	vivapain-2	0.0118	0.2675	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.094	0.1498
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0118	0.2675	0.562
Echinococcus multilocularis	cathepsin L cysteine protease	0.0118	0.2675	0.414
Leishmania major	cysteine peptidase A (CPA)	0.0118	0.2675	1
Onchocerca volvulus		0.0118	0.2675	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0118	0.2675	0.5207
Brugia malayi	Cathepsin L-like precursor	0.0081	0.094	0.1498
Onchocerca volvulus	Cathepsin F homolog	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Brugia malayi	Cathepsin L-like precursor	0.0118	0.2675	0.4262
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0162	0.4658	0.9266
Echinococcus multilocularis	cathepsin L cysteine protease	0.0118	0.2675	0.414
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0081	0.094	0.1498
Plasmodium vivax	vivapain-2	0.0118	0.2675	1
Brugia malayi	cathepsin L-like precursor	0.0081	0.094	0.1498
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4658	0.7422
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.01	0.1806	0.3702
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.01	0.1806	0.6293
Trypanosoma cruzi	cysteine peptidase, putative	0.0118	0.2675	0.562
Loa Loa (eye worm)	hypothetical protein	0.01	0.1806	0.2878
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Loa Loa (eye worm)	cysteine protease	0.0118	0.2675	0.4262
Brugia malayi	Cathepsin L-like precursor	0.0118	0.2675	0.4262
Echinococcus multilocularis	cathepsin b	0.0162	0.4658	0.7367
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0118	0.2675	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0118	0.2675	0.562
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0067	0.0332	0.0446
Onchocerca volvulus		0.0118	0.2675	1
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.01	0.1806	0.2727
Brugia malayi	Cathepsin L-like precursor	0.0118	0.2675	0.4262
Trypanosoma cruzi	cysteine peptidase, putative	0.0118	0.2675	0.562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0118	0.2675	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0118	0.2675	1
Onchocerca volvulus		0.0118	0.2675	1
Toxoplasma gondii	cathepsin CPL	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Entamoeba histolytica	cysteine proteinase, putative	0.0118	0.2675	1
Entamoeba histolytica	cysteine protease, putative	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.094	0.3182
Brugia malayi	cathepsin B-like cysteine proteinase	0.0162	0.4658	0.7422
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.0332	0.0413
Echinococcus multilocularis	cathepsin b	0.0162	0.4658	0.7367
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0067	0.0332	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0118	0.2675	1
Brugia malayi	eukaryotic initiation factor 4A	0.01	0.1806	0.2878
Loa Loa (eye worm)	cathepsin B	0.0067	0.0332	0.0529
Leishmania major	cathepsin L-like protease	0.0118	0.2675	1
Echinococcus granulosus	cathepsin b	0.0162	0.4658	0.7367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0118	0.2675	1
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.01	0.1806	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.01	0.1806	0.2727
Onchocerca volvulus		0.0118	0.2675	1
Onchocerca volvulus	Cathepsin L homolog	0.0118	0.2675	1
Onchocerca volvulus		0.0114	0.2463	0.878

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (binding)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1318204
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 871942