Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1013 | 0.1013 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0103 | 0.2269 | 0.2269 |
Loa Loa (eye worm) | disintegrin family protein | 0.0062 | 0.0914 | 0.3248 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1013 | 0.1013 |
Brugia malayi | Reprolysin | 0.0078 | 0.146 | 0.6436 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.012 | 0.2815 | 0.2815 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1013 | 0.36 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1013 | 0.0775 |
Echinococcus granulosus | adam | 0.0098 | 0.2116 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0312 | 0.111 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1013 | 0.4466 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0103 | 0.2269 | 0.1397 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0075 | 0.1345 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1345 | 0.4778 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0043 | 0.0312 | 0.1377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1013 | 0.1013 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0508 | 0.2237 |
Echinococcus multilocularis | geminin | 0.034 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1013 | 0.1013 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1013 | 0.1013 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0508 | 0.1803 |
Brugia malayi | angiogenesis inhibito | 0.0043 | 0.0312 | 0.1377 |
Schistosoma mansoni | hypothetical protein | 0.034 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1013 | 0.4466 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1013 | 0.36 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1108 | 0.3937 |
Brugia malayi | ADAMTS-like protease | 0.0043 | 0.0312 | 0.1377 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0508 | 0.1803 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.012 | 0.2815 | 0.2005 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1013 | 0.36 |
Brugia malayi | Disintegrin family protein | 0.0103 | 0.2269 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0075 | 0.1345 | 0.1116 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0508 | 0.2237 |
Brugia malayi | hypothetical protein | 0.0098 | 0.2116 | 0.9325 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0103 | 0.2269 | 0.2064 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0098 | 0.2116 | 0.2116 |
Echinococcus multilocularis | adam | 0.0098 | 0.2116 | 0.1227 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1013 | 0.4466 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0312 | 0.111 |
Schistosoma mansoni | hypothetical protein | 0.034 | 1 | 1 |
Loa Loa (eye worm) | reprolysin | 0.012 | 0.2815 | 1 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.012 | 0.2815 | 0.2624 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.012 | 0.2815 | 0.2815 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.04 p.p.m. | Inhibitory activity against Acetolactate synthase (ALS) enzyme by using the rape-root growth method | ChEMBL. | 10450955 |
IC50 (binding) | = 16.04 p.p.m. | Inhibitory activity against Acetolactate synthase (ALS) enzyme by using the rape-root growth method | ChEMBL. | 10450955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.