TDR Targets

Basic information

Technical information

TDR Targets ID: 874235
Name: N-(3-dimethylaminopropyl)-4-fluoro-N-(6-fluor o-1,3-benzothiazol-2-yl)benzamide
MW: 375.435 | Formula: C19H19F2N3OS
H donors: 0 H acceptors: 2 LogP: 4.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCN(C(=O)c1ccc(cc1)F)c1sc2c(n1)ccc(c2)F)C
InChi: 1S/C19H19F2N3OS/c1-23(2)10-3-11-24(18(25)13-4-6-14(20)7-5-13)19-22-16-9-8-15(21)12-17(16)26-19/h4-9,12H,3,10-11H2,1-2H3
InChiKey: YFYLQWDWWCBONL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0632	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.1364	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	PAN domain-containing protein	0.0073	0.0339	0.0305
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0311	0.4453	1
Brugia malayi	Trypsin family protein	0.0089	0.0619	0.0586
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Onchocerca volvulus		0.0543	0.8464	0.841
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.1364	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0632	1	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0082	0.0505	0.0404
Loa Loa (eye worm)	TK/ROR protein kinase	0.0257	0.3528	0.3506
Leishmania major	eukaryotic initiation factor 4a, putative	0.0311	0.4453	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0505	0.0472
Onchocerca volvulus	Arrow homolog	0.0082	0.0505	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Brugia malayi	Trypsin family protein	0.0089	0.0619	0.0586
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0619	0.0586
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0311	0.4453	0.4453
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0082	0.0505	0.0472
Leishmania major	eukaryotic initiation factor 4a, putative	0.0311	0.4453	1
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0082	0.0505	0.0472
Brugia malayi	Trypsin family protein	0.0089	0.0619	0.0586
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0082	0.0505	0.0404
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0311	0.4453	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0089	0.0619	0.0619
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0311	0.4453	1
Schistosoma mansoni	hypothetical protein	0.0187	0.232	0.232
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0311	0.4453	1
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Brugia malayi	Protein kinase domain containing protein	0.0257	0.3528	0.3506
Echinococcus granulosus	glycoprotein Antigen 5	0.0089	0.0619	0.0288
Brugia malayi	Calcium binding EGF domain containing protein	0.0082	0.0505	0.0472
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0311	0.4453	1
Loa Loa (eye worm)	hypothetical protein	0.0257	0.3528	0.3506
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0311	0.4453	1
Onchocerca volvulus		0.0089	0.0619	0.029
Echinococcus multilocularis	enteropeptidase	0.0089	0.0619	0.0288
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0089	0.0619	0.0586
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0311	0.4453	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Onchocerca volvulus		0.0089	0.0619	0.029
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0311	0.4453	1
Onchocerca volvulus		0.0089	0.0619	0.029
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0311	0.4453	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Echinococcus multilocularis	geminin	0.0187	0.232	0.4598
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0619	0.0586
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0311	0.4453	1
Plasmodium vivax	RNA helicase-1, putative	0.0311	0.4453	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.0888	0.0855
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0089	0.0619	0.0288
Brugia malayi	hypothetical protein	0.0089	0.0619	0.0586
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Onchocerca volvulus		0.0089	0.0619	0.029
Onchocerca volvulus		0.0257	0.3528	0.3302
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	PAN domain-containing protein	0.0073	0.0339	0.0305
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.3528	0.7408
Loa Loa (eye worm)	hypothetical protein	0.0311	0.4453	0.4433
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0505	0.0472
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0089	0.0619	0.0288
Echinococcus multilocularis	transmembrane protease serine 3	0.0089	0.0619	0.0288
Echinococcus multilocularis	glycoprotein Antigen 5	0.0089	0.0619	0.0288
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0311	0.4453	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.0888	0.0969
Toxoplasma gondii	kringle domain-containing protein	0.0257	0.3528	0.7754
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0311	0.4453	0.5
Loa Loa (eye worm)	PAN domain-containing protein	0.0073	0.0339	0.0305
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0632	1	1
Echinococcus granulosus	Mastin	0.0089	0.0619	0.0288
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.0888	0.0855
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0082	0.0505	0.0472
Schistosoma mansoni	hypothetical protein	0.0089	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0619	0.0586
Echinococcus multilocularis	tissue type plasminogen activator	0.0257	0.3528	0.7659
Echinococcus multilocularis	Mastin	0.0089	0.0619	0.0288
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	PAN domain-containing protein	0.0073	0.0339	0.0305
Schistosoma mansoni	hypothetical protein	0.0187	0.232	0.232
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0089	0.0619	0.0288
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0311	0.4453	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Treponema pallidum	ATP-dependent RNA helicase	0.0311	0.4453	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0089	0.0619	0.0619
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0888	0.0888
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0082	0.0505	0.0505
Loa Loa (eye worm)	trypsin family protein	0.0089	0.0619	0.0586
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.0888	0.0568
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0311	0.4453	0.4453
Brugia malayi	Fibulin-1 precursor	0.0082	0.0505	0.0472
Schistosoma mansoni	egf-like domain protein	0.0082	0.0505	0.0505
Brugia malayi	MH2 domain containing protein	0.0132	0.1364	0.1333
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0311	0.4453	1
Echinococcus granulosus	transmembrane protease serine 3	0.0089	0.0619	0.0288
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0505	0.0472
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0505	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0619	0.0586
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0089	0.0619	0.0619
Brugia malayi	Kringle domain containing protein	0.0257	0.3528	0.3506
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0089	0.0619	0.0619
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0505	0.0472
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0632	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Echinococcus granulosus	tissue type plasminogen activator	0.0257	0.3528	0.7659
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.0888	0.0969
Brugia malayi	eukaryotic initiation factor 4A	0.0311	0.4453	0.4433
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0619	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0632	1	1
Leishmania major	hypothetical protein, conserved	0.0257	0.3528	0.7408
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0339	0.0305
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0082	0.0505	0.0472
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Echinococcus granulosus	geminin	0.0187	0.232	0.4598
Brugia malayi	Trypsin-like protease protein 5	0.0089	0.0619	0.0586
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0311	0.4453	1
Schistosoma mansoni	hypothetical protein	0.0257	0.3528	0.3528
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0089	0.0619	0.0288
Schistosoma mansoni	cercarial elastase (S01 family)	0.0089	0.0619	0.0619
Onchocerca volvulus		0.0089	0.0619	0.029
Schistosoma mansoni	hypothetical protein	0.0089	0.0619	0.0619
Echinococcus granulosus	enteropeptidase	0.0089	0.0619	0.0288
Brugia malayi	PAN domain containing protein	0.0073	0.0339	0.0305
Mycobacterium ulcerans	hypothetical protein	0.0089	0.0619	0.5
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0311	0.4453	0.4258

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 874235