Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0153 | 0.4002 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0145 | 0.3717 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0325 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0145 | 0.3717 | 0.3717 |
Loa Loa (eye worm) | lipase | 0.0145 | 0.3717 | 0.3717 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0325 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0145 | 0.3717 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0145 | 0.3717 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0145 | 0.3717 | 0.5 |
Schistosoma mansoni | amidase | 0.0325 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0145 | 0.3717 | 1 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0325 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0153 | 0.4002 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 1 | 1 |
Onchocerca volvulus | 0.0145 | 0.3717 | 0.5 | |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0039 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0145 | 0.3717 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0325 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0145 | 0.3717 | 0.3717 |
Trypanosoma brucei | lipase domain protein, putative | 0.0145 | 0.3717 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0145 | 0.3717 | 0.3717 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0039 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.