Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Brugia malayi | eukaryotic initiation factor 4A | 0.0107 | 0.3565 | 0.3565 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0107 | 0.3565 | 0.6029 |
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0107 | 0.3565 | 0.6344 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.3565 | 0.3265 |
Leishmania major | cysteine peptidase A (CPA) | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0129 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0088 | 0.1788 | 0.1788 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0107 | 0.3565 | 0.3565 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0176 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0107 | 0.3565 | 0.6344 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0129 | 0.562 | 1 |
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0074 | 0.0446 | 0.0794 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.562 | 0.5415 |
Echinococcus multilocularis | cathepsin b | 0.0176 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0129 | 0.562 | 0.5415 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0129 | 0.562 | 0.562 |
Brugia malayi | cathepsin L-like precursor | 0.0088 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1788 | 0.1405 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0107 | 0.3565 | 0.6029 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0107 | 0.3565 | 0.6344 |
Plasmodium vivax | RNA helicase-1, putative | 0.0107 | 0.3565 | 0.6344 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0176 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0129 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin l1 | 0.0129 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.562 | 0.562 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0107 | 0.3565 | 0.3565 |
Entamoeba histolytica | cysteine protease, putative | 0.0129 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.0129 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0088 | 0.1788 | 0.1788 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0107 | 0.3565 | 0.6029 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0129 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0129 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.1788 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0129 | 0.562 | 0.562 |
Loa Loa (eye worm) | cysteine protease | 0.0129 | 0.562 | 0.5415 |
Echinococcus multilocularis | cysteine protease | 0.0129 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin b | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1788 | 0.1405 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0129 | 0.562 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0107 | 0.3565 | 0.4638 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0088 | 0.1788 | 0.1788 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0129 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0107 | 0.3565 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0176 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0129 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0129 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0129 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin L homolog | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0088 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0107 | 0.3565 | 0.3565 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0074 | 0.0446 | 0.0446 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0129 | 0.562 | 0.562 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0107 | 0.3565 | 0.6344 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0129 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.562 | 0.562 |
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0107 | 0.3565 | 0.6344 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0107 | 0.3565 | 0.3565 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0129 | 0.562 | 0.562 |
Plasmodium vivax | vivapain-2 | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0129 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.1788 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0129 | 0.562 | 0.562 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0107 | 0.3565 | 0.3565 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0129 | 0.562 | 0.5415 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0107 | 0.3565 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0074 | 0.0446 | 0.0794 |
Onchocerca volvulus | Cathepsin F homolog | 0.0129 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0129 | 0.562 | 0.562 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0129 | 0.562 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0107 | 0.3565 | 0.6344 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0129 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0074 | 0.0446 | 0.0446 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0107 | 0.3565 | 0.3565 |
Loa Loa (eye worm) | ctsf protein | 0.0129 | 0.562 | 0.5415 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0129 | 0.562 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0129 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin b | 0.0176 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0107 | 0.3565 | 0.3565 |
Onchocerca volvulus | 0.0129 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0176 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0107 | 0.3565 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1788 | 0.1405 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0129 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0107 | 0.3565 | 0.3565 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0088 | 0.1788 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0129 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.0129 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0129 | 0.562 | 0.562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.