Detailed information for compound 875913

Basic information

Technical information
  • TDR Targets ID: 875913
  • Name: 4,6,8-trimethyl-1H-quinolin-2-one
  • MW: 187.238 | Formula: C12H13NO
  • H donors: 1 H acceptors: 2 LogP: 3.26 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(c1)c(C)cc(n2)O
  • InChi: 1S/C12H13NO/c1-7-4-9(3)12-10(5-7)8(2)6-11(14)13-12/h4-6H,1-3H3,(H,13,14)
  • InChiKey: UHXASMSNKAVYHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,6,8-trimethylcarbostyril
  • 42414-28-8
  • AG-670/25097019
  • ST5328391
  • ZINC00333485
  • STK056531
  • InChI=1/C12H13NO/c1-7-4-9(3)12-10(5-7)8(2)6-11(14)13-12/h4-6H,1-3H3,(H,13,14
  • NSC108501

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0106 0.3698 0.3403
Loa Loa (eye worm) hypothetical protein 0.0126 0.562 0.5415
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Brugia malayi Cathepsin L-like precursor 0.0126 0.562 0.562
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.1788 0.1788
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0106 0.3698 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0106 0.3698 0.6579
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0086 0.1788 0.1788
Onchocerca volvulus Cathepsin L homolog 0.0126 0.562 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.1788 0.1405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0106 0.3698 0.5
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0106 0.3698 0.6579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.562 0.562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Plasmodium vivax RNA helicase-1, putative 0.0106 0.3698 0.6579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0106 0.3698 0.3698
Onchocerca volvulus 0.0126 0.562 1
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.562 0.562
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.562 0.562
Echinococcus granulosus cathepsin l1 0.0126 0.562 0.562
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0106 0.3698 0.3698
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.562 0.562
Loa Loa (eye worm) hypothetical protein 0.0171 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0126 0.562 0.562
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0106 0.3698 0.6579
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.562 0.562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Echinococcus multilocularis cysteine protease 0.0126 0.562 0.562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Brugia malayi Cathepsin L-like precursor 0.0126 0.562 0.562
Echinococcus granulosus eukaryotic initiation factor 4A 0.0106 0.3698 0.3698
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Onchocerca volvulus 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0106 0.3698 0.6284
Onchocerca volvulus Cathepsin L homolog 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0072 0.0446 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Schistosoma mansoni cathepsin F (C01 family) 0.0126 0.562 0.562
Loa Loa (eye worm) fibroinase 0.0126 0.562 0.5415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0106 0.3698 0.6579
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0106 0.3698 0.6579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Plasmodium vivax vivapain-2 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0072 0.0446 0.0446
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0126 0.562 0.5415
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Echinococcus multilocularis cysteine protease 0.0126 0.562 0.562
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0126 0.562 0.562
Plasmodium vivax vivapain-2 0.0126 0.562 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0106 0.3698 0.6284
Echinococcus granulosus cathepsin b 0.0171 1 1
Leishmania major cysteine peptidase A (CPA) 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Schistosoma mansoni cathepsin F (C01 family) 0.0126 0.562 0.562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1788 0.3182
Echinococcus multilocularis cathepsin L cysteine protease 0.0126 0.562 0.562
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.562 1
Brugia malayi Cathepsin L-like precursor 0.0126 0.562 0.562
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Onchocerca volvulus 0.0126 0.562 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0106 0.3698 0.6579
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0106 0.3698 0.4983
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Brugia malayi Cathepsin L-like precursor 0.0126 0.562 0.562
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0106 0.3698 0.3698
Echinococcus granulosus cathepsin L cysteine proteinase 0.0126 0.562 0.562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1788 0.3182
Echinococcus granulosus cathepsin l1 0.0086 0.1788 0.1788
Loa Loa (eye worm) cysteine protease 0.0126 0.562 0.5415
Toxoplasma gondii cathepsin CPL 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0086 0.1788 0.1788
Brugia malayi eukaryotic initiation factor 4A 0.0106 0.3698 0.3698
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0126 0.562 0.5415
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0106 0.3698 0.3698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0126 0.562 0.562
Loa Loa (eye worm) hypothetical protein 0.0086 0.1788 0.1405
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0106 0.3698 0.3698
Echinococcus granulosus cathepsin b 0.0171 1 1
Onchocerca volvulus 0.0126 0.562 1
Echinococcus multilocularis cathepsin b 0.0171 1 1
Echinococcus multilocularis cathepsin b 0.0171 1 1
Onchocerca volvulus Cathepsin F homolog 0.0126 0.562 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.1788 0.1405
Brugia malayi Cathepsin L-like precursor 0.0086 0.1788 0.1788
Treponema pallidum ATP-dependent RNA helicase 0.0106 0.3698 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1788 0.3182
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.562 0.562
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Brugia malayi cathepsin L-like precursor 0.0086 0.1788 0.1788
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0126 0.562 0.562
Leishmania major eukaryotic initiation factor 4a, putative 0.0106 0.3698 0.6284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0106 0.3698 0.3698
Onchocerca volvulus 0.0126 0.562 1
Leishmania major cathepsin L-like protease 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0072 0.0446 0.0794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Onchocerca volvulus 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0126 0.562 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0126 0.562 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0126 0.562 1
Brugia malayi Cathepsin L-like precursor 0.0126 0.562 0.562
Brugia malayi Cathepsin L-like precursor 0.0086 0.1788 0.1788
Loa Loa (eye worm) ctsf protein 0.0126 0.562 0.5415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.562 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.562 1
Onchocerca volvulus 0.0126 0.562 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0126 0.562 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0072 0.0446 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.562 1
Brugia malayi Cathepsin L-like precursor 0.0126 0.562 0.562
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.562 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0106 0.3698 0.3698
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0126 0.562 1
Leishmania major cathepsin L-like protease 0.0126 0.562 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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