TDR Targets

Basic information

Technical information

TDR Targets ID: 876147
Name: 6-ethyl-3-(3-methylbutyl)thieno[3,2-e]pyrimid in-4-one
MW: 250.36 | Formula: C13H18N2OS
H donors: 0 H acceptors: 1 LogP: 3.42 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCc1sc2c(c1)c(=O)n(cn2)CCC(C)C
InChi: 1S/C13H18N2OS/c1-4-10-7-11-12(17-10)14-8-15(13(11)16)6-5-9(2)3/h7-9H,4-6H2,1-3H3
InChiKey: WOFFDSPDCXBARK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-ethyl-3-isopentyl-thieno[3,2-e]pyrimidin-4-one
6-ethyl-3-isopentyl-4-thieno[3,2-e]pyrimidinone
6-ethyl-3-isoamyl-thieno[3,2-e]pyrimidin-4-one
ZINC00148863

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0407	0.147
Schistosoma mansoni	importin beta-1	0.0035	0.0074	0.0266
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0273	0.0985
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0261	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0203	0.0734
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0203	1
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0487	0.3689	1
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.1276	1	0.5
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2768	1
Schistosoma mansoni	hypothetical protein	0.0372	0.2768	1
Brugia malayi	RNA binding protein	0.0076	0.0407	0.1957
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.1154	0.1513
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0143	0.0466
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0124	0.0597
Echinococcus multilocularis	protein patched	0.0051	0.0203	0.0266
Loa Loa (eye worm)	hypothetical protein	0.006	0.0277	0.0999
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0407	0.1957
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.1276	1	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0277	0.133
Echinococcus multilocularis	snurportin 1	0.0372	0.2768	0.3629
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2079	0.751
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0203	0.0664
Leishmania major	polypeptide deformylase-like protein, putative	0.0487	0.3689	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0203	0.0734
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0277	0.0999
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0074	0.0199
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0407	0.133
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0746	0.2695
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0746	0.0978
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0261	0.1255
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0487	0.3689	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0074	0.0199
Brugia malayi	Importin beta-1 subunit	0.0035	0.0074	0.0354
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0021	0.1027
Entamoeba histolytica	hypothetical protein	0.0028	0.0021	0.028
Brugia malayi	hypothetical protein	0.0286	0.2079	1
Trypanosoma brucei	Polypeptide deformylase 1	0.0487	0.3689	1
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0074	0.024
Schistosoma mansoni	hypothetical protein	0.0043	0.0143	0.0515
Schistosoma mansoni	patched 1	0.0051	0.0203	0.0734
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.0746	0.3588
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.0761	0.2748
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0487	0.3689	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.7628	1
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0021	0.0057
Trypanosoma brucei	Peptide deformylase 2	0.0487	0.3689	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0407	0.0533
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0261	0.0942
Mycobacterium ulcerans	peptide deformylase	0.1276	1	0.5
Plasmodium falciparum	peptide deformylase	0.1276	1	1
Toxoplasma gondii	hypothetical protein	0.1276	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0277	0.133
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0407	0.147
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0143	0.0515
Plasmodium falciparum	importin beta, putative	0.0035	0.0074	0.0074
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2079	0.2726
Echinococcus granulosus	expressed conserved protein	0.0112	0.0688	0.225
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.1276	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0124	0.0449
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.0746	1
Brugia malayi	CHE-14 protein	0.0051	0.0203	0.0977
Schistosoma mansoni	hypothetical protein	0.0058	0.0261	0.0942
Brugia malayi	RNA, U transporter 1	0.0099	0.0587	0.2823
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0203	0.0266
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0021	0.0057
Schistosoma mansoni	hypothetical protein	0.0041	0.0124	0.0449
Brugia malayi	TAR-binding protein	0.0076	0.0407	0.1957
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0074	0.0074
Treponema pallidum	polypeptide deformylase (def)	0.1276	1	0.5
Echinococcus multilocularis	expressed conserved protein	0.0112	0.0688	0.0902
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0074	0.0096
Echinococcus multilocularis	tumor protein p63	0.0408	0.3059	0.401
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0	0.5
Brugia malayi	hypothetical protein	0.0043	0.0143	0.0686
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.1154	0.3773
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0487	0.3689	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0407	0.147
Echinococcus granulosus	snurportin 1	0.0372	0.2768	0.905
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0074	0.0074
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Loa Loa (eye worm)	hypothetical protein	0.006	0.0273	0.0985
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0203	0.0664
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0143	0.0187
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0746	0.2439
Onchocerca volvulus		0.006	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0266
Plasmodium vivax	peptide deformylase, putative	0.1276	1	1
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0021	0.1027
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2079	0.6797
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0021	0.1027
Echinococcus granulosus	tumor protein p63	0.0408	0.3059	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0295	0.1065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 876147